Modified histidine containing amphipathic ultrashort antifungal peptide, His[2-p-(n-butyl)phenyl]-Trp-Arg-OMe exhibits potent anticryptococcal activity

In pursuit of ultrashort peptide-based antifungals, a new structural class, His(2-aryl)-Trp-Arg is reported. Structural changes were investigated on His-Trp-Arg scaffold to demonstrate the impact of charge and lipophilic character on the biological activity. The presence and size of the aryl moiety...

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Veröffentlicht in:	European journal of medicinal chemistry 2021-11, Vol.223, p.113635-113635, Article 113635
Hauptverfasser:	Sharma, Krishna K., Ravi, Ravikant, Maurya, Indresh Kumar, Kapadia, Akshay, Khan, Shabana I., Kumar, Vinod, Tikoo, Kulbhushan, Jain, Rahul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiphilicity Antifungal peptides (AFPs) Cryptococcus neoformans Cytotoxicity Membrane selectivity Membrane-disruption
Online-Zugang:	Volltext
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