Anticancer potential of novel α,β-unsaturated γ-lactam derivatives targeting the PI3K/AKT signaling pathway

[Display omitted] Six recently synthesized alkyl (Z)-2-(2-oxopyrrolidin-3-ylidene)acetates were evaluated for their potential as cytotoxic and anticancer agents. All compounds were tested in the ERα positive MCF-7, triple negative MDA-MB-231, and Her2+ SKBR-3 breast cancer cell lines. The most lipop...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical pharmacology 2021-08, Vol.190, p.114659-114659, Article 114659
Hauptverfasser:	Brindisi, Matteo, Frattaruolo, Luca, Mancuso, Raffaella, Palumbo Piccionello, Antonio, Ziccarelli, Ida, Catto, Marco, Nicolotti, Orazio, Altomare, Cosimo D., Gabriele, Bartolo, Cappello, Anna Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Cytotoxicity PI3K/AKT signaling pathway α,β-Unsaturated lactams α-Methylene-γ-lactams
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!