Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus
Aims To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes. Methods We have made an in‐depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes w...
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| Veröffentlicht in: | Geriatrics & gerontology international 2021-08, Vol.21 (8), p.614-622 |
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| container_title | Geriatrics & gerontology international |
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| creator | Abdelhafiz, Ahmed H Emmerton, Demelza Sinclair, Alan J |
| description | Aims
To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes.
Methods
We have made an in‐depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes which might assist in predicting responses to particular glucose‐lowering therapy.
Results
Our review has enable us to describe with some confidence a sarcopenic obese phenotype and an anorexic malnourished phenotype.
Conclusions
By identifying these two phenotypes we can predict which would be most responsive to certain classes of therapy and where therapies may be ill‐advised. This represents the first novel approach in this area. Further work is being planned to develop this hypothesis. Geriatr Gerontol Int 2021; 21: 614–622. |
| doi_str_mv | 10.1111/ggi.14214 |
| format | Article |
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To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes.
Methods
We have made an in‐depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes which might assist in predicting responses to particular glucose‐lowering therapy.
Results
Our review has enable us to describe with some confidence a sarcopenic obese phenotype and an anorexic malnourished phenotype.
Conclusions
By identifying these two phenotypes we can predict which would be most responsive to certain classes of therapy and where therapies may be ill‐advised. This represents the first novel approach in this area. Further work is being planned to develop this hypothesis. Geriatr Gerontol Int 2021; 21: 614–622.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.14214</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Diabetes ; Frailty ; Genotype & phenotype ; management ; Metabolism ; Older people ; phenotype</subject><ispartof>Geriatrics & gerontology international, 2021-08, Vol.21 (8), p.614-622</ispartof><rights>2021 Japan Geriatrics Society.</rights><rights>2021 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3544-62712b4dd362f5df58401d9a26de38e6d35fb7c8100cc73aac4cbb81275c82163</citedby><cites>FETCH-LOGICAL-c3544-62712b4dd362f5df58401d9a26de38e6d35fb7c8100cc73aac4cbb81275c82163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.14214$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.14214$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Abdelhafiz, Ahmed H</creatorcontrib><creatorcontrib>Emmerton, Demelza</creatorcontrib><creatorcontrib>Sinclair, Alan J</creatorcontrib><title>Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus</title><title>Geriatrics & gerontology international</title><description>Aims
To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes.
Methods
We have made an in‐depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes which might assist in predicting responses to particular glucose‐lowering therapy.
Results
Our review has enable us to describe with some confidence a sarcopenic obese phenotype and an anorexic malnourished phenotype.
Conclusions
By identifying these two phenotypes we can predict which would be most responsive to certain classes of therapy and where therapies may be ill‐advised. This represents the first novel approach in this area. Further work is being planned to develop this hypothesis. Geriatr Gerontol Int 2021; 21: 614–622.</description><subject>Diabetes</subject><subject>Frailty</subject><subject>Genotype & phenotype</subject><subject>management</subject><subject>Metabolism</subject><subject>Older people</subject><subject>phenotype</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10EFLwzAYBuAiCs7pwX8Q8KKHbvnSpO2OIjoHAy96Lmnydctom9qkjP57s9WTYC7J4XnDyxtF90AXEM5ytzML4Az4RTQDzrOYihW_PL95DCJPr6Mb5w6UQrYCmEXVpumk8sRWpOqlqf1IGvSytLVRpNtja_3YoSO2JX6PpJGt3GGD7Tlha4096dB2NZKj8XtywoQRbWSJPsQarGvjB3cbXVWydnj3e8-jr7fXz5f3ePux3rw8b2OViFAwZRmwkmudpKwSuhI5p6BXkqUakxxTnYiqzFQOlCqVJVIqrsoyB5YJlTNIk3n0OP3b9fZ7QOeLxjgVSsgW7eAKJniSUZHAKtCHP_Rgh74N7YISGeMQNgvqaVKqt871WBVdbxrZjwXQ4rR4ERYvzosHu5zs0dQ4_g-L9XozJX4ArE-B8A</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Abdelhafiz, Ahmed H</creator><creator>Emmerton, Demelza</creator><creator>Sinclair, Alan J</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus</title><author>Abdelhafiz, Ahmed H ; Emmerton, Demelza ; Sinclair, Alan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3544-62712b4dd362f5df58401d9a26de38e6d35fb7c8100cc73aac4cbb81275c82163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes</topic><topic>Frailty</topic><topic>Genotype & phenotype</topic><topic>management</topic><topic>Metabolism</topic><topic>Older people</topic><topic>phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelhafiz, Ahmed H</creatorcontrib><creatorcontrib>Emmerton, Demelza</creatorcontrib><creatorcontrib>Sinclair, Alan J</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdelhafiz, Ahmed H</au><au>Emmerton, Demelza</au><au>Sinclair, Alan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus</atitle><jtitle>Geriatrics & gerontology international</jtitle><date>2021-08</date><risdate>2021</risdate><volume>21</volume><issue>8</issue><spage>614</spage><epage>622</epage><pages>614-622</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aims
To provide a pathophysiological basis for distinguishing metabolic variants of the frailty phenotype in older adults with type 2 diabetes.
Methods
We have made an in‐depth review of the possible mechanisms in diabetes, ageing and frailty that will alter allow us to describe phenotypic changes which might assist in predicting responses to particular glucose‐lowering therapy.
Results
Our review has enable us to describe with some confidence a sarcopenic obese phenotype and an anorexic malnourished phenotype.
Conclusions
By identifying these two phenotypes we can predict which would be most responsive to certain classes of therapy and where therapies may be ill‐advised. This represents the first novel approach in this area. Further work is being planned to develop this hypothesis. Geriatr Gerontol Int 2021; 21: 614–622.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><doi>10.1111/ggi.14214</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1444-1586 |
| ispartof | Geriatrics & gerontology international, 2021-08, Vol.21 (8), p.614-622 |
| issn | 1444-1586 1447-0594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2543705319 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Diabetes Frailty Genotype & phenotype management Metabolism Older people phenotype |
| title | Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus |
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