Establishment of Detection Methods for Five Cannabinoids in Hemp Cosmetics Based on HPLC
A simultaneously HPLC detection method for cannabidiolic acid (CBDA), cannabidiol (CBD), cannabinol (CBN), Δ9-tetrahydrocannabinol (THC), tetrahydro-cannabinolic acid (THCA) in 3 kinds of cosmetics matrix containing hemp leaf extract was developed. The extraction and HPLC conditions were optimized,...
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| Veröffentlicht in: | Analytical Sciences 2021/12/10, Vol.37(12), pp.1821-1824 |
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| container_title | Analytical Sciences |
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| creator | SUN, Dong-Mei SONG, Lun WANG, Hai-Yan YU, Cong-Cong CHU, Qiao LAN, Tao ZHANG, Wei-Bing |
| description | A simultaneously HPLC detection method for cannabidiolic acid (CBDA), cannabidiol (CBD), cannabinol (CBN), Δ9-tetrahydrocannabinol (THC), tetrahydro-cannabinolic acid (THCA) in 3 kinds of cosmetics matrix containing hemp leaf extract was developed. The extraction and HPLC conditions were optimized, and a methodological verification was also carried out. The results showed that this method had a good linear relationship in the range of 0.25 – 50 μg/mL with LOD values for 5 cannabinoids all between 0.10 – 0.25 μg/g. The recovery rates of 5 cannabinoids in 3 different cosmetics matrixes were between 90.1 – 108.5%, and the RSD values were all below 4.4%. These results indicated that this method had the advantages of simple operation, high sensitivity, and good accuracy. Through the testing of 6 kinds of hemp cosmetics, it was found that such cosmetics had uneven quality. The establishment of this method can lay a methodological foundation for establishing relevant testing method standards. |
| doi_str_mv | 10.2116/analsci.21P158 |
| format | Article |
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The extraction and HPLC conditions were optimized, and a methodological verification was also carried out. The results showed that this method had a good linear relationship in the range of 0.25 – 50 μg/mL with LOD values for 5 cannabinoids all between 0.10 – 0.25 μg/g. The recovery rates of 5 cannabinoids in 3 different cosmetics matrixes were between 90.1 – 108.5%, and the RSD values were all below 4.4%. These results indicated that this method had the advantages of simple operation, high sensitivity, and good accuracy. Through the testing of 6 kinds of hemp cosmetics, it was found that such cosmetics had uneven quality. The establishment of this method can lay a methodological foundation for establishing relevant testing method standards.</description><identifier>ISSN: 0910-6340</identifier><identifier>EISSN: 1348-2246</identifier><identifier>DOI: 10.2116/analsci.21P158</identifier><identifier>PMID: 34148924</identifier><language>eng</language><publisher>Singapore: The Japan Society for Analytical Chemistry</publisher><subject>Analytical Chemistry ; Cannabinoids ; Cannabinoids - analysis ; Cannabis ; Chemistry ; Chromatography, High Pressure Liquid ; Cosmetics ; Hemp ; Hemp cosmetics ; High-performance liquid chromatography ; high-performance liquid chromatography (HPLC) ; Liquid chromatography ; Plant extracts ; Tetrahydrocannabinol</subject><ispartof>Analytical Sciences, 2021/12/10, Vol.37(12), pp.1821-1824</ispartof><rights>2021 by The Japan Society for Analytical Chemistry</rights><rights>The Japan Society for Analytical Chemistry 2021</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c683t-462b0c5435dc3c77c44d0bd867fff5160193bb945e06d91d91d0f48e39aaccee3</citedby><cites>FETCH-LOGICAL-c683t-462b0c5435dc3c77c44d0bd867fff5160193bb945e06d91d91d0f48e39aaccee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.2116/analsci.21P158$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.2116/analsci.21P158$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1876,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34148924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUN, Dong-Mei</creatorcontrib><creatorcontrib>SONG, Lun</creatorcontrib><creatorcontrib>WANG, Hai-Yan</creatorcontrib><creatorcontrib>YU, Cong-Cong</creatorcontrib><creatorcontrib>CHU, Qiao</creatorcontrib><creatorcontrib>LAN, Tao</creatorcontrib><creatorcontrib>ZHANG, Wei-Bing</creatorcontrib><title>Establishment of Detection Methods for Five Cannabinoids in Hemp Cosmetics Based on HPLC</title><title>Analytical Sciences</title><addtitle>ANAL. SCI</addtitle><addtitle>Anal Sci</addtitle><description>A simultaneously HPLC detection method for cannabidiolic acid (CBDA), cannabidiol (CBD), cannabinol (CBN), Δ9-tetrahydrocannabinol (THC), tetrahydro-cannabinolic acid (THCA) in 3 kinds of cosmetics matrix containing hemp leaf extract was developed. The extraction and HPLC conditions were optimized, and a methodological verification was also carried out. The results showed that this method had a good linear relationship in the range of 0.25 – 50 μg/mL with LOD values for 5 cannabinoids all between 0.10 – 0.25 μg/g. The recovery rates of 5 cannabinoids in 3 different cosmetics matrixes were between 90.1 – 108.5%, and the RSD values were all below 4.4%. These results indicated that this method had the advantages of simple operation, high sensitivity, and good accuracy. Through the testing of 6 kinds of hemp cosmetics, it was found that such cosmetics had uneven quality. The establishment of this method can lay a methodological foundation for establishing relevant testing method standards.</description><subject>Analytical Chemistry</subject><subject>Cannabinoids</subject><subject>Cannabinoids - analysis</subject><subject>Cannabis</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cosmetics</subject><subject>Hemp</subject><subject>Hemp cosmetics</subject><subject>High-performance liquid chromatography</subject><subject>high-performance liquid chromatography (HPLC)</subject><subject>Liquid chromatography</subject><subject>Plant extracts</subject><subject>Tetrahydrocannabinol</subject><issn>0910-6340</issn><issn>1348-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9r2zAUx8XYWLK21x2HYJdd3OqXZfu4uWlTyGgPLfQmZPk5UbClTHIK---n4DSDQkFI6L3P96vHVwh9peSSUSqvtNN9NDZdHmhefkBzykWZMSbkRzQnFSWZ5ILM0JcYt4RQVjL2Gc24oKKsmJij50UcddPbuBnAjdh3-BpGMKP1Dv-GcePbiDsf8I19AVxr53Rjnbepah1ewrDDtY8DjNZE_EtHaHESLh9W9Tn61KXR4OJ4nqGnm8VjvcxW97d39c9VZmTJx0xI1hCTC563hpuiMEK0pGlLWXRdl1NJaMWbphI5ENlW9LBIJ0rgldbGAPAz9GPy3QX_Zw9xVIONBvpeO_D7qFjyLojgVZHQ72_Qrd-HQ4CKSZoXuRQ5T9TlRJngYwzQqV2wgw5_FSXqkLk6Zq6mzJPg29F23wzQnvDXkBNwNQExtdwawv9337VcTIpt-p01nCx1SEH3cMJ5oSg77JPu1DcbHRQ4_g8ea6YR</recordid><startdate>20211210</startdate><enddate>20211210</enddate><creator>SUN, Dong-Mei</creator><creator>SONG, Lun</creator><creator>WANG, Hai-Yan</creator><creator>YU, Cong-Cong</creator><creator>CHU, Qiao</creator><creator>LAN, Tao</creator><creator>ZHANG, Wei-Bing</creator><general>The Japan Society for Analytical Chemistry</general><general>Springer Nature Singapore</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20211210</creationdate><title>Establishment of Detection Methods for Five Cannabinoids in Hemp Cosmetics Based on HPLC</title><author>SUN, Dong-Mei ; 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| subjects | Analytical Chemistry Cannabinoids Cannabinoids - analysis Cannabis Chemistry Chromatography, High Pressure Liquid Cosmetics Hemp Hemp cosmetics High-performance liquid chromatography high-performance liquid chromatography (HPLC) Liquid chromatography Plant extracts Tetrahydrocannabinol |
| title | Establishment of Detection Methods for Five Cannabinoids in Hemp Cosmetics Based on HPLC |
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