SRY-Box 21 Antisense RNA 1 Knockdown Diminishes Amyloid Beta25–35-Induced Neuronal Damage by miR-132/PI3K/AKT Pathway

Our study aimed to explore the function and mechanism of action of long noncoding RNA (lncRNA) SRY-Box 21 antisense RNA 1 (SOX21-AS1) in amyloid beta 25–35 (Aβ 25–35 )-induced neuronal damage. To induce neuronal damage, neuronal cells and differentiated IMR-32 neuroblastoma cells were challenged by...

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Veröffentlicht in:	Neurochemical research 2021-09, Vol.46 (9), p.2376-2386
Hauptverfasser:	Gu, Fengming, Ji, Daofei, Ni, Hongzao, Chen, Depeng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Antisense RNA Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Caspase-3 Cell Biology Cell differentiation Cell viability Damage assessment Damage detection Evaluation Flow cytometry Kinases Neuroblastoma cells Neurochemistry Neurology Neurosciences Original Paper Oxidative stress Polymerase chain reaction Proteins Reactive oxygen species Reverse transcription Ribonucleic acid RNA
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