Sphingosine-1-phosphate induces myocyte autophagy after myocardial infarction through mTOR inhibition

Sphingosine-1-phosphate (S1P)/S1P receptor 1 signaling exerts cardioprotective effects including inhibition of myocyte apoptosis. However, little is known about the effect of S1P treatment on myocyte autophagy after myocardial infarction (MI). In the present study, we tested the hypothesis that S1P...

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Veröffentlicht in:	European journal of pharmacology 2021-09, Vol.907, p.174260, Article 174260
Hauptverfasser:	Yang, Li-Guo, Wang, Ai-Ling, Li, Lu, Yang, Hong, Jie, Xi, Zhu, Zong-Feng, Zhang, Xiao-Juan, Zhao, Hui-Ping, Chi, Rui-Fang, Li, Bao, Qin, Fu-Zhong, Wang, Jia-Pu, Wang, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - drug effects Cell Line Left ventricular remodeling Life Sciences & Biomedicine Lysophospholipids - pharmacology Male mTOR Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocyte autophagy Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Pharmacology & Pharmacy Rats Rats, Sprague-Dawley Science & Technology Signal Transduction - drug effects Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine-1-phosphate TOR Serine-Threonine Kinases - metabolism Ventricular Function, Left - drug effects
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