Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma

Drug resistance remains the major obstacle limiting the effectiveness of chemotherapy for esophageal squamous cell carcinoma (ESCC)[1]. However, how stromal cells cooperate with immune cells to contribute to drug resistance is not yet fully understood. In this study, we observed that monocytic myelo...

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Veröffentlicht in:	Cancer letters 2021-10, Vol.518, p.35-48
Hauptverfasser:	Zhao, Qitai, Huang, Lan, Qin, Guohui, Qiao, Yamin, Ren, Feifei, Shen, Chunyi, Wang, Shumin, Liu, Shasha, Lian, Jinyao, Wang, Dan, Yu, Weina, Zhang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autocrine signalling Cancer-associated fibroblasts Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology CD11b antigen Cell Differentiation - physiology Cell Line Cell Line, Tumor Chemotherapy Cisplatin Cisplatin - pharmacology Cisplatin resistance Drug resistance Drug Resistance, Neoplasm - physiology Esophageal cancer Esophageal Neoplasms - drug therapy Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - pathology Esophagus Ethics Exosomes - metabolism Exosomes - pathology Extracellular matrix Fibroblasts Flow cytometry Growth factors Humans Interleukin 6 Interleukin 6 receptors Interleukin-6 - metabolism Lymphocytes Medical prognosis Metastases Metastasis MicroRNAs MicroRNAs - metabolism miRNA Monocytes Monocytes - metabolism Monocytes - pathology Monocytic myeloid-derived suppressor cells Myeloid cells Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid-Derived Suppressor Cells - metabolism Myeloid-Derived Suppressor Cells - pathology Paracrine signalling Patients Proteins Signal transducing activator of transcription 3 Signal Transduction - physiology Squamous cell carcinoma Stat3 protein STAT3 Transcription Factor - metabolism Stromal cells Suppressor cells Transcription Tumor cells Tumors
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