Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1

Nonalcoholic steatohepatitis (NASH)-related hepatocellular carcinoma and liver disorders have become the leading causes for the need of liver transplantation in developed countries. Lipotoxicity plays a central role in NASH progression by causing endoplasmic reticulum stress and disrupting protein h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2021-07, Vol.33 (7), p.1372-1388.e7
Hauptverfasser:	Wang, Lin, Zhang, Xin, Lin, Zhi-Bin, Yang, Pei-Jun, Xu, Hao, Duan, Juan-Li, Ruan, Bai, Song, Ping, Liu, Jing-Jing, Yue, Zhen-Sheng, Fang, Zhi-Qiang, Hu, Heng, Liu, Zhen, Huang, Xiao-Li, Yang, Ling, Tian, Song, Tao, Kai-Shan, Han, Hua, Dou, Ke-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Disease Models, Animal HEK293 Cells Hepatocytes - metabolism Hepatocytes - pathology Humans Liver - metabolism Liver - pathology Male MAP Kinase Kinase Kinases - metabolism Mice Mice, Inbred C57BL Mice, Knockout Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology nonalcoholic steatohepatitis Phosphoproteins - metabolism Phosphorylation Proteolysis Signal Transduction - genetics TAK1 TRIM16 Tripartite Motif Proteins - physiology Ubiquitin-Protein Ligases - physiology ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!