Notch signaling supports the appearance of follicular helper T cells in the Peyer’s patches concomitantly with the reduction of regulatory T cells

Abstract The intracellular fragment of Notch1, a mediator of Notch signaling that is frequently detected in thymic immigrants, is critical for specifying T-cell fate in the thymus, where Delta-like 4 (Dll4) functions as a Notch ligand on the epithelium. However, as such Notch signaling has not been...

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