Microglia contribute to social behavioral adaptation to chronic stress

Microglial activation has been regarded mainly as an exacerbator of stress response, a common symptom in psychiatric disorders. This study aimed to determine whether microglia contribute to adaptive response of the brain and behavior toward stress using a mild and adaptive stress model – chronic res...

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Veröffentlicht in:	Glia 2021-10, Vol.69 (10), p.2459-2473
Hauptverfasser:	Piirainen, Sami, Chithanathan, Keerthana, Bisht, Kanchan, Piirsalu, Maria, Savage, Julie Conner, Tremblay, Marie‐Eve, Tian, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Animals Anxiety Brain chronic stress CX3C Chemokine Receptor 1 - genetics CX3C Chemokine Receptor 1 - metabolism CX3CR1 CX3CR1 protein Glutamic acid transporter Hippocampus - metabolism Homozygotes Humans Mental disorders Mice Mice, Inbred C57BL Microglia Microglia - metabolism microglial polarization microglial presynaptic pruning mRNA Phagocytosis Protein transport Schizophrenia Social behavior Social factors Spatial discrimination learning Stress Stress response Stress, Psychological Subpopulations
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