ctDNA guiding adjuvant immunotherapy in urothelial carcinoma

Minimally invasive approaches to detect residual disease after surgery are needed to identify patients with cancer who are at risk for metastatic relapse. Circulating tumour DNA (ctDNA) holds promise as a biomarker for molecular residual disease and relapse 1 . We evaluated outcomes in 581 patients...

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Veröffentlicht in:	Nature (London) 2021-07, Vol.595 (7867), p.432-437
Hauptverfasser:	Powles, Thomas, Assaf, Zoe June, Davarpanah, Nicole, Banchereau, Romain, Szabados, Bernadett E., Yuen, Kobe C., Grivas, Petros, Hussain, Maha, Oudard, Stephane, Gschwend, Jürgen E., Albers, Peter, Castellano, Daniel, Nishiyama, Hiroyuki, Daneshmand, Siamak, Sharma, Shruti, Zimmermann, Bernhard G., Sethi, Himanshu, Aleshin, Alexey, Perdicchio, Maurizio, Zhang, Jingbin, Shames, David S., Degaonkar, Viraj, Shen, Xiaodong, Carter, Corey, Bais, Carlos, Bellmunt, Joaquim, Mariathasan, Sanjeev
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 38/23 38/39 38/77 38/91 631/67/589/1336 692/53/2423 Adjuvants Adjuvants, Pharmaceutic - therapeutic use Angiogenesis Antibodies, Monoclonal, Humanized - therapeutic use Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Bladder cancer Cancer Care and treatment Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Confidence intervals Deoxyribonucleic acid DNA Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Health hazards Humanities and Social Sciences Humans Immune clearance Immune response Immune system Immunotherapy Kaplan-Meier Estimate Keratin Medical prognosis Metastases Methods multidisciplinary Mutation Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - genetics Patients Plasma Population Postoperative Care Prognosis Recurrence Science Science (multidisciplinary) Surgery Survival Survival Analysis Tumors Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urothelial cancer Urothelial carcinoma
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