Chemo‐mechanistic multi‐scale model of a three‐dimensional tumor microenvironment to quantify the chemotherapy response of cancer

Exploring efficient chemotherapy would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. As in vivo experimental methods are unable to isolate or control individual factors of the TME, and in vitro models often cannot include all the contribut...

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Veröffentlicht in:	Biotechnology and bioengineering 2021-10, Vol.118 (10), p.3871-3887
Hauptverfasser:	Nikmaneshi, Mohammad R., Firoozabadi, Bahar, Mozafari, Aliasghar
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - therapeutic use Antiangiogenics Antineoplastic Agents - therapeutic use Antineoplastic drugs Antitumor agents Cancer Cancer therapies Chemotherapy combination therapy Computer applications Drug delivery Drug Delivery Systems Experimental methods Humans Hyperglycemia IFP In vivo methods and tests Mathematical analysis Mathematical models Models, Cardiovascular Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - metabolism Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Scale models Systems Biology Tumor Microenvironment Tumors vascular normalization
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