Plasma BDNF and insight in OCD: a promising path for future research
In the last 10 years, insight emerged as a potential explanation for the limited success of pharmacotherapy and psychotherapy in OCD, with inefficacy rates of 20–25%, which prompted the need for more research on this topic (Eisen et al., 2001). [...]attention has been drawn to the different factors...
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| Veröffentlicht in: | Acta neuropsychiatrica 2021-10, Vol.33 (5), p.277-279 |
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| container_end_page | 279 |
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| container_issue | 5 |
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| container_title | Acta neuropsychiatrica |
| container_volume | 33 |
| creator | Manarte, Lucas Saldanha, João Andrade, António R Tanqueiro, Sara Morgado, Pedro Sahakian, Barbara J |
| description | In the last 10 years, insight emerged as a potential explanation for the limited success of pharmacotherapy and psychotherapy in OCD, with inefficacy rates of 20–25%, which prompted the need for more research on this topic (Eisen et al., 2001). [...]attention has been drawn to the different factors influencing insight, and, among them, the brain-derived neurotrophic factor (BDNF) was linked to the pathogenesis of several neuropsychiatric disorders, including OCD. [...]when poor-insight patients were removed from the analysis, the BDNF difference between OCD patients and controls disappeared. Whether insight in OCD patients can be improved by psychological therapies targeting poor insight remains to be determined. [...]few studies have focused on the correlation between BDNF and OCD severity. |
| doi_str_mv | 10.1017/neu.2021.17 |
| format | Article |
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| source | MEDLINE; Cambridge Journals |
| subjects | Analysis of covariance Antidepressants Brain research Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Gender Genetic Predisposition to Disease Humans Mental disorders Neurobiology Obsessive compulsive disorder Polymorphism, Single Nucleotide Variance analysis |
| title | Plasma BDNF and insight in OCD: a promising path for future research |
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