Innate immune cells in the tumor microenvironment
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determini...
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| Veröffentlicht in: | Cancer cell 2021-06, Vol.39 (6), p.725-729 |
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| container_title | Cancer cell |
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| creator | Li, Ming O. Wolf, Natalie Raulet, David H. Akkari, Leila Pittet, Mikael J. Rodriguez, Paulo C. Kaplan, Rosandra N. Munitz, Ariel Zhang, Zemin Cheng, Sijin Bhardwaj, Nina |
| description | The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues. |
| doi_str_mv | 10.1016/j.ccell.2021.05.016 |
| format | Article |
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The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.</description><identifier>ISSN: 1535-6108</identifier><identifier>EISSN: 1878-3686</identifier><identifier>DOI: 10.1016/j.ccell.2021.05.016</identifier><identifier>PMID: 34129817</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cancer Vaccines - pharmacology ; Dendritic Cells - immunology ; Humans ; Immunity, Innate ; Immunotherapy - methods ; Killer Cells, Natural - immunology ; Lymphocytes - immunology ; Lymphocytes - pathology ; Mast Cells - immunology ; Mast Cells - pathology ; Myeloid-Derived Suppressor Cells - immunology ; Neoplasms - immunology ; Neoplasms - pathology ; Neoplasms - therapy ; Neutrophils - immunology ; Tumor Microenvironment - immunology ; Tumor-Associated Macrophages - immunology ; Tumor-Associated Macrophages - pathology</subject><ispartof>Cancer cell, 2021-06, Vol.39 (6), p.725-729</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-ca93e0fbf899c70be894fa62663ac0b70fded42071952edc38fb78f130e43af23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ccell.2021.05.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34129817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ming O.</creatorcontrib><creatorcontrib>Wolf, Natalie</creatorcontrib><creatorcontrib>Raulet, David H.</creatorcontrib><creatorcontrib>Akkari, Leila</creatorcontrib><creatorcontrib>Pittet, Mikael J.</creatorcontrib><creatorcontrib>Rodriguez, Paulo C.</creatorcontrib><creatorcontrib>Kaplan, Rosandra N.</creatorcontrib><creatorcontrib>Munitz, Ariel</creatorcontrib><creatorcontrib>Zhang, Zemin</creatorcontrib><creatorcontrib>Cheng, Sijin</creatorcontrib><creatorcontrib>Bhardwaj, Nina</creatorcontrib><title>Innate immune cells in the tumor microenvironment</title><title>Cancer cell</title><addtitle>Cancer Cell</addtitle><description>The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.</description><subject>Cancer Vaccines - pharmacology</subject><subject>Dendritic Cells - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunotherapy - methods</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - pathology</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - pathology</subject><subject>Myeloid-Derived Suppressor Cells - immunology</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - therapy</subject><subject>Neutrophils - immunology</subject><subject>Tumor Microenvironment - immunology</subject><subject>Tumor-Associated Macrophages - immunology</subject><subject>Tumor-Associated Macrophages - pathology</subject><issn>1535-6108</issn><issn>1878-3686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBUgoSzYJfiSxs2CBKh6VKrGBteU4Y-GqdoqdVOLvcWhhyWpGozN37lyErgkuCCb13abQGrbbgmJKClwVaXaC5kRwkbNa1Kepr1iV1wSLGbqIcYMTQXhzjmasJLQRhM8RWXmvBsisc6OHbBKMmfXZ8AHZMLo-ZM7q0IPf29B7B364RGdGbSNcHesCvT89vi1f8vXr82r5sM51icsh16phgE1rRNNojlsQTWlUTeuaKY1bjk0HXUkxJ01FodNMmJYLQxiGkilD2QLdHnR3of8cIQ7S2Tj5Ux76MUpalYSL6aGEsgOanMYYwMhdsE6FL0mwnLKSG_mTlZyykriSaZa2bo4HxtZB97fzG04C7g8ApDf3FoKM2oLX0NkAepBdb_898A38n3sl</recordid><startdate>20210614</startdate><enddate>20210614</enddate><creator>Li, Ming O.</creator><creator>Wolf, Natalie</creator><creator>Raulet, David H.</creator><creator>Akkari, Leila</creator><creator>Pittet, Mikael J.</creator><creator>Rodriguez, Paulo C.</creator><creator>Kaplan, Rosandra N.</creator><creator>Munitz, Ariel</creator><creator>Zhang, Zemin</creator><creator>Cheng, Sijin</creator><creator>Bhardwaj, Nina</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210614</creationdate><title>Innate immune cells in the tumor microenvironment</title><author>Li, Ming O. ; Wolf, Natalie ; Raulet, David H. ; Akkari, Leila ; Pittet, Mikael J. ; Rodriguez, Paulo C. ; Kaplan, Rosandra N. ; Munitz, Ariel ; Zhang, Zemin ; Cheng, Sijin ; Bhardwaj, Nina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-ca93e0fbf899c70be894fa62663ac0b70fded42071952edc38fb78f130e43af23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer Vaccines - pharmacology</topic><topic>Dendritic Cells - immunology</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Immunotherapy - methods</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - pathology</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - pathology</topic><topic>Myeloid-Derived Suppressor Cells - immunology</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - therapy</topic><topic>Neutrophils - immunology</topic><topic>Tumor Microenvironment - immunology</topic><topic>Tumor-Associated Macrophages - immunology</topic><topic>Tumor-Associated Macrophages - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ming O.</creatorcontrib><creatorcontrib>Wolf, Natalie</creatorcontrib><creatorcontrib>Raulet, David H.</creatorcontrib><creatorcontrib>Akkari, Leila</creatorcontrib><creatorcontrib>Pittet, Mikael J.</creatorcontrib><creatorcontrib>Rodriguez, Paulo C.</creatorcontrib><creatorcontrib>Kaplan, Rosandra N.</creatorcontrib><creatorcontrib>Munitz, Ariel</creatorcontrib><creatorcontrib>Zhang, Zemin</creatorcontrib><creatorcontrib>Cheng, Sijin</creatorcontrib><creatorcontrib>Bhardwaj, Nina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ming O.</au><au>Wolf, Natalie</au><au>Raulet, David H.</au><au>Akkari, Leila</au><au>Pittet, Mikael J.</au><au>Rodriguez, Paulo C.</au><au>Kaplan, Rosandra N.</au><au>Munitz, Ariel</au><au>Zhang, Zemin</au><au>Cheng, Sijin</au><au>Bhardwaj, Nina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Innate immune cells in the tumor microenvironment</atitle><jtitle>Cancer cell</jtitle><addtitle>Cancer Cell</addtitle><date>2021-06-14</date><risdate>2021</risdate><volume>39</volume><issue>6</issue><spage>725</spage><epage>729</epage><pages>725-729</pages><issn>1535-6108</issn><eissn>1878-3686</eissn><abstract>The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.
The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies. Experts discuss recent advances in our understanding of their biology in cancer as well as outstanding questions and potential therapeutic avenues.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34129817</pmid><doi>10.1016/j.ccell.2021.05.016</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer cell, 2021-06, Vol.39 (6), p.725-729 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | Cancer Vaccines - pharmacology Dendritic Cells - immunology Humans Immunity, Innate Immunotherapy - methods Killer Cells, Natural - immunology Lymphocytes - immunology Lymphocytes - pathology Mast Cells - immunology Mast Cells - pathology Myeloid-Derived Suppressor Cells - immunology Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Neutrophils - immunology Tumor Microenvironment - immunology Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - pathology |
| title | Innate immune cells in the tumor microenvironment |
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