ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show low proliferation rates despite a WNT/β-Catenin activity gradient required for metabolic liver zonation. The mechanisms...

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Veröffentlicht in:	Cell stem cell 2021-10, Vol.28 (10), p.1822-1837.e10
Hauptverfasser:	Sun, Tianliang, Annunziato, Stefano, Bergling, Sebastian, Sheng, Caibin, Orsini, Vanessa, Forcella, Pascal, Pikiolek, Monika, Kancherla, Venkatesh, Holwerda, Sjoerd, Imanci, Dilek, Wu, Fabian, Meylan, Ludivine Challet, Puehringer, Lea F., Waldt, Annick, Oertli, Mevion, Schuierer, Sven, Terracciano, Luigi M., Reinker, Stefan, Ruffner, Heinz, Bouwmeester, Tewis, Sailer, Andreas W., George, Elizabeth, Roma, Guglielmo, de Weck, Antoine, Piscuoglio, Salvatore, Lohmann, Felix, Naumann, Ulrike, Liberali, Prisca, Cong, Feng, Tchorz, Jan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AXIN2+ hepatocytes beta Catenin - metabolism Cell Proliferation hepatocellular carcinoma Hepatocytes - metabolism instestinal stem cells LGR5 Liver - growth & development Liver - metabolism liver regeneration liver zonation metabolism Mice R-Spondin spatial transcriptomics Stem Cells - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism WNT signaling Wnt Signaling Pathway
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