The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis

Background and Aims Stratified therapy has entered clinical practice in primary biliary cholangitis (PBC), with routine use of second‐line therapy in nonresponders to first‐line therapy with ursodeoxycholic acid (UDCA). The mechanism for nonresponse to UDCA remains, however, unclear and we lack mech...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2021-12, Vol.74 (6), p.3269-3283
Hauptverfasser:	Barron‐Millar, Ben, Ogle, Laura, Mells, George, Flack, Steven, Badrock, Jonathan, Sandford, Richard, Kirby, John, Palmer, Jeremy, Jopson, Laura, Brain, John, Smith, Graham R., Rushton, Steve, Hegade, Vinod S., Jones, Rebecca, Rushbrook, Simon, Thorburn, Douglas, Ryder, Steve, Hirschfield, Gideon, Dyson, Jessica K., Jones, David E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biliary Tract - cytology Biliary Tract - metabolism Biomarkers Biomarkers - blood Case-Control Studies CCL20 protein Chemokines Chemokines - blood Cholangitis Discriminant analysis Epithelial cells Epithelial Cells - metabolism Female Hepatology Humans Inflammation Ligands Liver Cirrhosis, Biliary - blood Liver Cirrhosis, Biliary - drug therapy Liver Cirrhosis, Biliary - metabolism Male Middle Aged Patients Proteome Proteomes Proteomics Senescence Serum levels Treatment Failure Ursodeoxycholic acid Ursodeoxycholic Acid - therapeutic use
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