Upregulation of antigen presentation function and inflammation in chondrocytes by induction of proteoglycan aggrecan peptides (P16-31 and P263-280)

A central hallmark of osteoarthritis (OA) is cartilage destruction. Chondrocytes not only control cartilage metabolism, but are capable of immunogenic responses. The role of chondrocytes in the pathogenesis of OA is still unclear. In this study, we aimed to determine the immunological role of chondr...

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Veröffentlicht in:	Clinical and experimental rheumatology 2022-03, Vol.40 (3), p.596-607
Hauptverfasser:	Sengprasert, Panjana, Leearamwat, Nitikorn, Ngarmukos, Srihatach, Yuktananda, Pongsak, Tanavalee, Aree, Reantragoon, Rangsima
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecans - metabolism Antigen Presentation Cartilage, Articular - metabolism Cells, Cultured Chondrocytes - metabolism Humans Inflammation - pathology Interferon-gamma - metabolism Osteoarthritis, Knee - metabolism Proteoglycans - metabolism Up-Regulation
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