Understanding giant cell sarcoma of the head and neck: A population‐based study
Background Giant cell sarcomas (GCS) are rare head and neck neoplasms. Methods The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014. Results Four hundred and forty cases of GCS of the head and neck were ident...
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| Veröffentlicht in: | Head & neck 2021-09, Vol.43 (9), p.2786-2794 |
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| creator | Sawhney, Rohan Ahsanuddin, Salma Sheorey, Lena Wassef, David W. Baredes, Soly Park, Richard Chan Woo |
| description | Background
Giant cell sarcomas (GCS) are rare head and neck neoplasms.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.
Results
Four hundred and forty cases of GCS of the head and neck were identified. The average age at diagnosis was 74.4 years, 86.8% were white, 82.5% were male, 70.7% were insured, and 88.2% lived in an urban metropolitan region. Connective tissue was the most frequent primary site (42.5%). The 5Y‐DSS rate was 91.1%, while the 5Y‐OS was 54.6% for all cases. Patients treated with surgery alone had the highest 5Y‐DSS rate of 94.5. T‐classification odds ratio was a significant predictor of survival accounting for confounding variables on multivariate analysis.
Conclusions
GCS presents most frequently in connective tissue of the head and neck with overall high probability of survival. The treatment of choice is surgery alone. |
| doi_str_mv | 10.1002/hed.26765 |
| format | Article |
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Giant cell sarcomas (GCS) are rare head and neck neoplasms.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.
Results
Four hundred and forty cases of GCS of the head and neck were identified. The average age at diagnosis was 74.4 years, 86.8% were white, 82.5% were male, 70.7% were insured, and 88.2% lived in an urban metropolitan region. Connective tissue was the most frequent primary site (42.5%). The 5Y‐DSS rate was 91.1%, while the 5Y‐OS was 54.6% for all cases. Patients treated with surgery alone had the highest 5Y‐DSS rate of 94.5. T‐classification odds ratio was a significant predictor of survival accounting for confounding variables on multivariate analysis.
Conclusions
GCS presents most frequently in connective tissue of the head and neck with overall high probability of survival. The treatment of choice is surgery alone.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26765</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Connective tissue ; Connective tissues ; Epidemiology ; Head & neck cancer ; Head and neck ; head and neck chemotherapy ; head and neck cutaneous ; head and neck radiation therapy ; head and neck sarcoma ; Multivariate analysis ; Neoplasia ; Patients ; Population studies ; Population-based studies ; Sarcoma ; Surgery</subject><ispartof>Head & neck, 2021-09, Vol.43 (9), p.2786-2794</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3305-340ec5124737681cf09313fb6df0dcacfcb77f065e8da4fabe1081a51b285ba43</citedby><cites>FETCH-LOGICAL-c3305-340ec5124737681cf09313fb6df0dcacfcb77f065e8da4fabe1081a51b285ba43</cites><orcidid>0000-0002-9081-2832</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26765$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26765$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Sawhney, Rohan</creatorcontrib><creatorcontrib>Ahsanuddin, Salma</creatorcontrib><creatorcontrib>Sheorey, Lena</creatorcontrib><creatorcontrib>Wassef, David W.</creatorcontrib><creatorcontrib>Baredes, Soly</creatorcontrib><creatorcontrib>Park, Richard Chan Woo</creatorcontrib><title>Understanding giant cell sarcoma of the head and neck: A population‐based study</title><title>Head & neck</title><description>Background
Giant cell sarcomas (GCS) are rare head and neck neoplasms.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.
Results
Four hundred and forty cases of GCS of the head and neck were identified. The average age at diagnosis was 74.4 years, 86.8% were white, 82.5% were male, 70.7% were insured, and 88.2% lived in an urban metropolitan region. Connective tissue was the most frequent primary site (42.5%). The 5Y‐DSS rate was 91.1%, while the 5Y‐OS was 54.6% for all cases. Patients treated with surgery alone had the highest 5Y‐DSS rate of 94.5. T‐classification odds ratio was a significant predictor of survival accounting for confounding variables on multivariate analysis.
Conclusions
GCS presents most frequently in connective tissue of the head and neck with overall high probability of survival. The treatment of choice is surgery alone.</description><subject>Connective tissue</subject><subject>Connective tissues</subject><subject>Epidemiology</subject><subject>Head & neck cancer</subject><subject>Head and neck</subject><subject>head and neck chemotherapy</subject><subject>head and neck cutaneous</subject><subject>head and neck radiation therapy</subject><subject>head and neck sarcoma</subject><subject>Multivariate analysis</subject><subject>Neoplasia</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Sarcoma</subject><subject>Surgery</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10L9OwzAQBvAIgUQpDLyBJRYY0p5jO07ZqlIoUiWERGfL8Z82JXWCnQh14xF4Rp6ElDAhMd0Nvzt9-qLoEsMIAyTjjdGjJOUpO4oGGCY8BkL58WGnJCbA6Wl0FsIWAEhKk0H0vHLa-NBIpwu3RutCugYpU5YoSK-qnUSVRc3GoI2RGnUKOaNeb9EU1VXdlrIpKvf18ZnLYDQKTav359GJlWUwF79zGK3u5y-zRbx8enicTZexIgRYTCgYxXBCOeFphpWFCcHE5qm2oJVUVuWcW0iZybSkVuYGQ4Ylw3mSsVxSMoyu-7-1r95aExqxK8IhuXSmaoNIGAWepITijl79oduq9a5L1yk2AcATmnbqplfKVyF4Y0Xti530e4FBHMoVXbnip9zOjnv7XpRm_z8Ui_ldf_ENGbN7Cg</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sawhney, Rohan</creator><creator>Ahsanuddin, Salma</creator><creator>Sheorey, Lena</creator><creator>Wassef, David W.</creator><creator>Baredes, Soly</creator><creator>Park, Richard Chan Woo</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9081-2832</orcidid></search><sort><creationdate>202109</creationdate><title>Understanding giant cell sarcoma of the head and neck: A population‐based study</title><author>Sawhney, Rohan ; Ahsanuddin, Salma ; Sheorey, Lena ; Wassef, David W. ; Baredes, Soly ; Park, Richard Chan Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3305-340ec5124737681cf09313fb6df0dcacfcb77f065e8da4fabe1081a51b285ba43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Connective tissue</topic><topic>Connective tissues</topic><topic>Epidemiology</topic><topic>Head & neck cancer</topic><topic>Head and neck</topic><topic>head and neck chemotherapy</topic><topic>head and neck cutaneous</topic><topic>head and neck radiation therapy</topic><topic>head and neck sarcoma</topic><topic>Multivariate analysis</topic><topic>Neoplasia</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Sarcoma</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawhney, Rohan</creatorcontrib><creatorcontrib>Ahsanuddin, Salma</creatorcontrib><creatorcontrib>Sheorey, Lena</creatorcontrib><creatorcontrib>Wassef, David W.</creatorcontrib><creatorcontrib>Baredes, Soly</creatorcontrib><creatorcontrib>Park, Richard Chan Woo</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sawhney, Rohan</au><au>Ahsanuddin, Salma</au><au>Sheorey, Lena</au><au>Wassef, David W.</au><au>Baredes, Soly</au><au>Park, Richard Chan Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Understanding giant cell sarcoma of the head and neck: A population‐based study</atitle><jtitle>Head & neck</jtitle><date>2021-09</date><risdate>2021</risdate><volume>43</volume><issue>9</issue><spage>2786</spage><epage>2794</epage><pages>2786-2794</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Giant cell sarcomas (GCS) are rare head and neck neoplasms.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for all patients who have been diagnosed with GCS from 1973 to 2014.
Results
Four hundred and forty cases of GCS of the head and neck were identified. The average age at diagnosis was 74.4 years, 86.8% were white, 82.5% were male, 70.7% were insured, and 88.2% lived in an urban metropolitan region. Connective tissue was the most frequent primary site (42.5%). The 5Y‐DSS rate was 91.1%, while the 5Y‐OS was 54.6% for all cases. Patients treated with surgery alone had the highest 5Y‐DSS rate of 94.5. T‐classification odds ratio was a significant predictor of survival accounting for confounding variables on multivariate analysis.
Conclusions
GCS presents most frequently in connective tissue of the head and neck with overall high probability of survival. The treatment of choice is surgery alone.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/hed.26765</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9081-2832</orcidid></addata></record> |
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| subjects | Connective tissue Connective tissues Epidemiology Head & neck cancer Head and neck head and neck chemotherapy head and neck cutaneous head and neck radiation therapy head and neck sarcoma Multivariate analysis Neoplasia Patients Population studies Population-based studies Sarcoma Surgery |
| title | Understanding giant cell sarcoma of the head and neck: A population‐based study |
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