Behavioral and neurobiological changes in a novel mouse model of schizophrenia induced by the combination of cuprizone and MK-801

•A novel mouse model of schizophrenia was established by MK-801 plus Cuprizone.•The novel model showed severe memory deficits, hyperactivity and anxiety disorder.•The novel model showed obvious demyelination and white matter damage.•The novel model displayed dysregulations in Fyn and NMDARs. Schizop...

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Veröffentlicht in:	Brain research bulletin 2021-09, Vol.174, p.141-152
Hauptverfasser:	Sun, Zheng-yu, Gu, Li-Hong, Ma, Deng-lei, Wang, Ming-yang, Yang, Cui-cui, Zhang, Lan, Li, Xin-min, Zhang, Jie-wen, Li, Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal model Cuprizone Fyn MK-801 NMDA receptor Schizophrenia White matter lesion
Online-Zugang:	Volltext
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