Maternal methionine supplementation in mice affects long-term body weight and locomotor activity of adult female offspring
Methionine is a precursor of s-adenosylmethionine, the main donor of methyl radicals for methylation of DNA and other compounds. Previous studies have shown that reduced availability of methyl radicals during pregnancy/lactation decreased offspring perigonadal white adipose tissue (PWAT) and body we...
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| Veröffentlicht in: | British journal of nutrition 2022-04, Vol.127 (8), p.1143-1152 |
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| creator | Cavalcante-Silva, Vanessa Ribeiro da Silva Vallim, Julia Fernandes, Leandro de Oliveira, Allan Chiaratti D’Almeida, Vânia |
| description | Methionine is a precursor of s-adenosylmethionine, the main donor of methyl radicals for methylation of DNA and other compounds. Previous studies have shown that reduced availability of methyl radicals during pregnancy/lactation decreased offspring perigonadal white adipose tissue (PWAT) and body weight. Therefore, we aimed to evaluate the effects of methionine supplementation during early development, a time of great ontogenic plasticity, by assessing the biometric, biochemical and behavioural parameters of the offspring of adult Swiss female mice supplemented with 1 % methionine in water 1 month before pregnancy, during pregnancy or pregnancy/lactation. After birth, the offspring were distributed into three groups: control (CT), methionine supplementation during pregnancy (SP) and methionine supplementation during pregnancy and lactation (SPL), and were followed until postnatal day (PND) 300. No changes were observed in offspring birth weight in both sexes. At PND 5, 28 and 90, no differences in body weight were found in females; however, at PND 300, SP and SPL females showed an increase in body weight when compared with the control group. This increase in body weight was accompanied by a total and relative increase in PWAT, and a decrease in locomotor activity in these groups. No differences in the body and organ weights were found in male offspring. In conclusion, the increased availability of methyl radicals during pregnancy and lactation impacted long-term body composition and locomotor activity in female offspring. |
| doi_str_mv | 10.1017/S0007114521002075 |
| format | Article |
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Previous studies have shown that reduced availability of methyl radicals during pregnancy/lactation decreased offspring perigonadal white adipose tissue (PWAT) and body weight. Therefore, we aimed to evaluate the effects of methionine supplementation during early development, a time of great ontogenic plasticity, by assessing the biometric, biochemical and behavioural parameters of the offspring of adult Swiss female mice supplemented with 1 % methionine in water 1 month before pregnancy, during pregnancy or pregnancy/lactation. After birth, the offspring were distributed into three groups: control (CT), methionine supplementation during pregnancy (SP) and methionine supplementation during pregnancy and lactation (SPL), and were followed until postnatal day (PND) 300. No changes were observed in offspring birth weight in both sexes. At PND 5, 28 and 90, no differences in body weight were found in females; however, at PND 300, SP and SPL females showed an increase in body weight when compared with the control group. This increase in body weight was accompanied by a total and relative increase in PWAT, and a decrease in locomotor activity in these groups. No differences in the body and organ weights were found in male offspring. In conclusion, the increased availability of methyl radicals during pregnancy and lactation impacted long-term body composition and locomotor activity in female offspring.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114521002075</identifier><identifier>PMID: 34121648</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adenosylmethionine ; Adipose tissue ; Animals ; Availability ; Birth weight ; Blood ; Body composition ; Body fat ; Body Weight ; Developmental Biology ; Dietary Supplements ; DNA methylation ; Female ; Females ; Homocysteine ; Laboratory animals ; Lactation ; Locomotion ; Locomotor activity ; Male ; Males ; Methionine ; Methionine - pharmacology ; Methyl radicals ; Mice ; Nutrition research ; Offspring ; Plasma ; Pregnancy ; Radicals ; S-Adenosylmethionine ; Sperm ; Supplements ; Vitamin B ; Vitamin deficiency</subject><ispartof>British journal of nutrition, 2022-04, Vol.127 (8), p.1143-1152</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-ea2fae7c5a377e5042b9a83ba48512f1a844dbf22d40730c9a30a73988b244d3</citedby><cites>FETCH-LOGICAL-c373t-ea2fae7c5a377e5042b9a83ba48512f1a844dbf22d40730c9a30a73988b244d3</cites><orcidid>0000-0003-0947-5312 ; 0000-0001-7729-9985</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114521002075/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34121648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cavalcante-Silva, Vanessa</creatorcontrib><creatorcontrib>Ribeiro da Silva Vallim, Julia</creatorcontrib><creatorcontrib>Fernandes, Leandro</creatorcontrib><creatorcontrib>de Oliveira, Allan Chiaratti</creatorcontrib><creatorcontrib>D’Almeida, Vânia</creatorcontrib><title>Maternal methionine supplementation in mice affects long-term body weight and locomotor activity of adult female offspring</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Methionine is a precursor of s-adenosylmethionine, the main donor of methyl radicals for methylation of DNA and other compounds. Previous studies have shown that reduced availability of methyl radicals during pregnancy/lactation decreased offspring perigonadal white adipose tissue (PWAT) and body weight. Therefore, we aimed to evaluate the effects of methionine supplementation during early development, a time of great ontogenic plasticity, by assessing the biometric, biochemical and behavioural parameters of the offspring of adult Swiss female mice supplemented with 1 % methionine in water 1 month before pregnancy, during pregnancy or pregnancy/lactation. After birth, the offspring were distributed into three groups: control (CT), methionine supplementation during pregnancy (SP) and methionine supplementation during pregnancy and lactation (SPL), and were followed until postnatal day (PND) 300. No changes were observed in offspring birth weight in both sexes. At PND 5, 28 and 90, no differences in body weight were found in females; however, at PND 300, SP and SPL females showed an increase in body weight when compared with the control group. This increase in body weight was accompanied by a total and relative increase in PWAT, and a decrease in locomotor activity in these groups. No differences in the body and organ weights were found in male offspring. In conclusion, the increased availability of methyl radicals during pregnancy and lactation impacted long-term body composition and locomotor activity in female offspring.</description><subject>Adenosylmethionine</subject><subject>Adipose tissue</subject><subject>Animals</subject><subject>Availability</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Body Weight</subject><subject>Developmental Biology</subject><subject>Dietary Supplements</subject><subject>DNA methylation</subject><subject>Female</subject><subject>Females</subject><subject>Homocysteine</subject><subject>Laboratory animals</subject><subject>Lactation</subject><subject>Locomotion</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Males</subject><subject>Methionine</subject><subject>Methionine - pharmacology</subject><subject>Methyl radicals</subject><subject>Mice</subject><subject>Nutrition research</subject><subject>Offspring</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Radicals</subject><subject>S-Adenosylmethionine</subject><subject>Sperm</subject><subject>Supplements</subject><subject>Vitamin B</subject><subject>Vitamin deficiency</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUtr3DAUhUVoSSaPH9BNEXTTjRu9bNnLENIHJGTR7M21fDVRsKSJJSdMf300ZNpAS1fi6nznXKRDyAfOvnDG9flPxpjmXNWCMyaYrg_IiitdV6JpxDuy2snVTj8ixyk9lLHlrDskR1JxwRvVrsivG8g4B5iox3zvYnABaVo2mwk9hgy5XFEXqHcGKViLJic6xbCuis3TIY5b-oxufZ8phLEoJvqY40zBZPfk8pZGS2FcpkwtepiwzDZtZhfWp-S9hSnh2f48IXdfr-4uv1fXt99-XF5cV0ZqmSsEYQG1qUFqjTVTYuiglQOotubCcmiVGgcrxKiYlsx0IBlo2bXtIIoiT8jn19jNHB8XTLn3LhmcJggYl9SLuviEaBQr6Ke_0Ie47D6nUI1qmo63sisUf6XMHFOa0fblOR7mbc9Zv-ul_6eX4vm4T14Gj-Mfx-8iCiD3oeCH2Y1rfNv9_9gXkQWYUw</recordid><startdate>20220428</startdate><enddate>20220428</enddate><creator>Cavalcante-Silva, Vanessa</creator><creator>Ribeiro da Silva Vallim, Julia</creator><creator>Fernandes, Leandro</creator><creator>de Oliveira, Allan Chiaratti</creator><creator>D’Almeida, Vânia</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0947-5312</orcidid><orcidid>https://orcid.org/0000-0001-7729-9985</orcidid></search><sort><creationdate>20220428</creationdate><title>Maternal methionine supplementation in mice affects long-term body weight and locomotor activity of adult female offspring</title><author>Cavalcante-Silva, Vanessa ; Ribeiro da Silva Vallim, Julia ; Fernandes, Leandro ; de Oliveira, Allan Chiaratti ; D’Almeida, Vânia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-ea2fae7c5a377e5042b9a83ba48512f1a844dbf22d40730c9a30a73988b244d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenosylmethionine</topic><topic>Adipose tissue</topic><topic>Animals</topic><topic>Availability</topic><topic>Birth weight</topic><topic>Blood</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Body Weight</topic><topic>Developmental Biology</topic><topic>Dietary Supplements</topic><topic>DNA methylation</topic><topic>Female</topic><topic>Females</topic><topic>Homocysteine</topic><topic>Laboratory animals</topic><topic>Lactation</topic><topic>Locomotion</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Males</topic><topic>Methionine</topic><topic>Methionine - 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Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cavalcante-Silva, Vanessa</au><au>Ribeiro da Silva Vallim, Julia</au><au>Fernandes, Leandro</au><au>de Oliveira, Allan Chiaratti</au><au>D’Almeida, Vânia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal methionine supplementation in mice affects long-term body weight and locomotor activity of adult female offspring</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2022-04-28</date><risdate>2022</risdate><volume>127</volume><issue>8</issue><spage>1143</spage><epage>1152</epage><pages>1143-1152</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Methionine is a precursor of s-adenosylmethionine, the main donor of methyl radicals for methylation of DNA and other compounds. Previous studies have shown that reduced availability of methyl radicals during pregnancy/lactation decreased offspring perigonadal white adipose tissue (PWAT) and body weight. Therefore, we aimed to evaluate the effects of methionine supplementation during early development, a time of great ontogenic plasticity, by assessing the biometric, biochemical and behavioural parameters of the offspring of adult Swiss female mice supplemented with 1 % methionine in water 1 month before pregnancy, during pregnancy or pregnancy/lactation. After birth, the offspring were distributed into three groups: control (CT), methionine supplementation during pregnancy (SP) and methionine supplementation during pregnancy and lactation (SPL), and were followed until postnatal day (PND) 300. No changes were observed in offspring birth weight in both sexes. At PND 5, 28 and 90, no differences in body weight were found in females; however, at PND 300, SP and SPL females showed an increase in body weight when compared with the control group. This increase in body weight was accompanied by a total and relative increase in PWAT, and a decrease in locomotor activity in these groups. No differences in the body and organ weights were found in male offspring. In conclusion, the increased availability of methyl radicals during pregnancy and lactation impacted long-term body composition and locomotor activity in female offspring.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>34121648</pmid><doi>10.1017/S0007114521002075</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0947-5312</orcidid><orcidid>https://orcid.org/0000-0001-7729-9985</orcidid></addata></record> |
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| subjects | Adenosylmethionine Adipose tissue Animals Availability Birth weight Blood Body composition Body fat Body Weight Developmental Biology Dietary Supplements DNA methylation Female Females Homocysteine Laboratory animals Lactation Locomotion Locomotor activity Male Males Methionine Methionine - pharmacology Methyl radicals Mice Nutrition research Offspring Plasma Pregnancy Radicals S-Adenosylmethionine Sperm Supplements Vitamin B Vitamin deficiency |
| title | Maternal methionine supplementation in mice affects long-term body weight and locomotor activity of adult female offspring |
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