Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers
The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs). CS-NPs (461.2–482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic...
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| Veröffentlicht in: | Carbohydrate polymers 2021-09, Vol.267, p.118157-118157, Article 118157 |
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| creator | Kim, Eun Suh Kim, Da Young Lee, Ji-Soo Lee, Hyeon Gyu |
| description | The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs). CS-NPs (461.2–482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic gum (AG, >250 kDa), or hyaluronic acid (HA, >1000 kDa). Mucoadhesion and cell permeation of QUE were significantly increased by positive charged CS-NPs due to interactions with negatively charged mucosal layer. Moreover, CS-AG and CS-HA NPs prepared with relatively higher MW cross-linkers exhibited significantly higher adhesion and permeation than the others. These results were verified by a cellular antioxidant activity assay; CS-AG (137.5 unit) and CS-HA NPs (126.5 unit) showed significantly higher activities after internalization into Caco-2 cells. Therefore, encapsulation within CS-NPs prepared using high MW cross-linkers such as AG and HA is found to be potentially valuable techniques for improving the QUE absorption.
•Chitosan formed nanoparticles by ionic gelation with (−) charged cross-linkers.•Quercetin (QUE) was encapsulated within chitosan nanoparticles (CS NPs).•Mucoadhesion and intestinal cell permeation of QUE was improved by CS NPs.•Cross-linker with higher MW improved adhesiveness and permeability of CS NPs.•QUE within CS NPs by hyaluronic acid or arabic gum showed the highest activity. |
| doi_str_mv | 10.1016/j.carbpol.2021.118157 |
| format | Article |
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•Chitosan formed nanoparticles by ionic gelation with (−) charged cross-linkers.•Quercetin (QUE) was encapsulated within chitosan nanoparticles (CS NPs).•Mucoadhesion and intestinal cell permeation of QUE was improved by CS NPs.•Cross-linker with higher MW improved adhesiveness and permeability of CS NPs.•QUE within CS NPs by hyaluronic acid or arabic gum showed the highest activity.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2021.118157</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Antioxidant activity ; Cell permeability ; Chitosan ; Cross-linker ; Mucoadhesion ; Nanoencapsulation</subject><ispartof>Carbohydrate polymers, 2021-09, Vol.267, p.118157-118157, Article 118157</ispartof><rights>2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-3812632d7b493c08a98fefbe8042f3397eca3d2071048dd8de8bd05148918e443</citedby><cites>FETCH-LOGICAL-c342t-3812632d7b493c08a98fefbe8042f3397eca3d2071048dd8de8bd05148918e443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2021.118157$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Kim, Eun Suh</creatorcontrib><creatorcontrib>Kim, Da Young</creatorcontrib><creatorcontrib>Lee, Ji-Soo</creatorcontrib><creatorcontrib>Lee, Hyeon Gyu</creatorcontrib><title>Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers</title><title>Carbohydrate polymers</title><description>The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs). CS-NPs (461.2–482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic gum (AG, >250 kDa), or hyaluronic acid (HA, >1000 kDa). Mucoadhesion and cell permeation of QUE were significantly increased by positive charged CS-NPs due to interactions with negatively charged mucosal layer. Moreover, CS-AG and CS-HA NPs prepared with relatively higher MW cross-linkers exhibited significantly higher adhesion and permeation than the others. These results were verified by a cellular antioxidant activity assay; CS-AG (137.5 unit) and CS-HA NPs (126.5 unit) showed significantly higher activities after internalization into Caco-2 cells. Therefore, encapsulation within CS-NPs prepared using high MW cross-linkers such as AG and HA is found to be potentially valuable techniques for improving the QUE absorption.
•Chitosan formed nanoparticles by ionic gelation with (−) charged cross-linkers.•Quercetin (QUE) was encapsulated within chitosan nanoparticles (CS NPs).•Mucoadhesion and intestinal cell permeation of QUE was improved by CS NPs.•Cross-linker with higher MW improved adhesiveness and permeability of CS NPs.•QUE within CS NPs by hyaluronic acid or arabic gum showed the highest activity.</description><subject>Antioxidant activity</subject><subject>Cell permeability</subject><subject>Chitosan</subject><subject>Cross-linker</subject><subject>Mucoadhesion</subject><subject>Nanoencapsulation</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFUE1rGzEQFaGFuEl_QkHHXtbVSFqv9lRK6BcESiA5C1mareXK0nYkJ_jQ_95NnXvnMszjvcebx9g7EGsQsPmwX3tH27mktRQS1gAG-uGCrcAMYwdK61dsJUDrzmxguGRvat2LZTYgVuzP3RHJY4uZB0zxEenE_c6R8w0p1hZ95WVaoNhKdZlnl8vsaMETVj4TLgcG_hTbjoc4TUiYGz-UhP6YHPEnjD93jS_hTi7HkrmnUmuXYv6FVK_Z68mlim9f9hV7-PL5_uZbd_vj6_ebT7edV1q2ThmQGyXDsNWj8sK40Uw4bdEILSelxgG9U0GKAYQ2IZiAZhtED9qMYFBrdcXen31nKr-PWJs9xOoxJZexHKuVvRaDFAD9Qu3P1H9BCSc7Uzw4OlkQ9rluu7cvddvnuu257kX38azD5Y_HiGSrj5g9hkjomw0l_sfhL46gjt0</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Kim, Eun Suh</creator><creator>Kim, Da Young</creator><creator>Lee, Ji-Soo</creator><creator>Lee, Hyeon Gyu</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210901</creationdate><title>Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers</title><author>Kim, Eun Suh ; Kim, Da Young ; Lee, Ji-Soo ; Lee, Hyeon Gyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-3812632d7b493c08a98fefbe8042f3397eca3d2071048dd8de8bd05148918e443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antioxidant activity</topic><topic>Cell permeability</topic><topic>Chitosan</topic><topic>Cross-linker</topic><topic>Mucoadhesion</topic><topic>Nanoencapsulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Eun Suh</creatorcontrib><creatorcontrib>Kim, Da Young</creatorcontrib><creatorcontrib>Lee, Ji-Soo</creatorcontrib><creatorcontrib>Lee, Hyeon Gyu</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Eun Suh</au><au>Kim, Da Young</au><au>Lee, Ji-Soo</au><au>Lee, Hyeon Gyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers</atitle><jtitle>Carbohydrate polymers</jtitle><date>2021-09-01</date><risdate>2021</risdate><volume>267</volume><spage>118157</spage><epage>118157</epage><pages>118157-118157</pages><artnum>118157</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>The aim of the study was to investigate the effects of cross-linkers on quercetin (QUE) absorption characteristics of QUE-loaded chitosan nanoparticles (CS-NPs). CS-NPs (461.2–482.7 nm) were prepared by ionic gelation at pH 3.5 using tripolyphosphate (367.9 Da), dextran sulfate (>15 kDa), arabic gum (AG, >250 kDa), or hyaluronic acid (HA, >1000 kDa). Mucoadhesion and cell permeation of QUE were significantly increased by positive charged CS-NPs due to interactions with negatively charged mucosal layer. Moreover, CS-AG and CS-HA NPs prepared with relatively higher MW cross-linkers exhibited significantly higher adhesion and permeation than the others. These results were verified by a cellular antioxidant activity assay; CS-AG (137.5 unit) and CS-HA NPs (126.5 unit) showed significantly higher activities after internalization into Caco-2 cells. Therefore, encapsulation within CS-NPs prepared using high MW cross-linkers such as AG and HA is found to be potentially valuable techniques for improving the QUE absorption.
•Chitosan formed nanoparticles by ionic gelation with (−) charged cross-linkers.•Quercetin (QUE) was encapsulated within chitosan nanoparticles (CS NPs).•Mucoadhesion and intestinal cell permeation of QUE was improved by CS NPs.•Cross-linker with higher MW improved adhesiveness and permeability of CS NPs.•QUE within CS NPs by hyaluronic acid or arabic gum showed the highest activity.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.carbpol.2021.118157</doi><tpages>1</tpages></addata></record> |
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| ispartof | Carbohydrate polymers, 2021-09, Vol.267, p.118157-118157, Article 118157 |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Antioxidant activity Cell permeability Chitosan Cross-linker Mucoadhesion Nanoencapsulation |
| title | Quercetin delivery characteristics of chitosan nanoparticles prepared with different molecular weight polyanion cross-linkers |
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