Functional outcomes rather than complications predict poor health-related quality of life at 6 months after robot-assisted radical prostatectomy
The objective is to evaluate the effect of robot-assisted radical prostatectomy (RARP)-related postoperative complications on the 6-month postoperative health-related quality of life (HRQoL). A total of 1008 patients underwent a RARP with or without pelvic lymph node dissection (PLND) between 2012 a...
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| Veröffentlicht in: | Journal of robotic surgery 2022-04, Vol.16 (2), p.453-462 |
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| creator | Hagens, Marinus J. Veerman, H. de Ligt, K. M. Tillier, C. N. van Leeuwen, P. J. van Moorselaar, R. J. A. van der Poel, H. G. |
| description | The objective is to evaluate the effect of robot-assisted radical prostatectomy (RARP)-related postoperative complications on the 6-month postoperative health-related quality of life (HRQoL). A total of 1008 patients underwent a RARP with or without pelvic lymph node dissection (PLND) between 2012 and 2020 and were invited to complete questionnaires about HRQoL and functional outcomes (urinary incontinence (UI), erectile dysfunction (ED) and urinary complaints (UC)) before and 6 months after RARP. Patient characteristics and postoperative complications up to 90 days after surgery were prospectively recorded. Associations between complications and HRQoL/functional outcomes were assessed by multivariate linear regression analyses. In total, 528 patients (52.4%) were included in the analyses. Complications occurred in 165/528 (31.3%) patients, of which 30/165 (18.2%) had a Clavien–Dindo ≥ III complication. In multivariate regression analyses, postoperative complications were not significantly associated with postoperative HRQoL, UI and ED (
p
= 0.73,
p
= 0.72 and
p
= 0.95, respectively), but were significantly associated with a minor increase in UC (β = 1.7,
p
|
| doi_str_mv | 10.1007/s11701-021-01266-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2540720009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2540720009</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-78ebffa4fae5e571f11beb71fe2bcfb51c3d903984f971e524902a9eb71e80473</originalsourceid><addsrcrecordid>eNp9kUFu1TAQhi1ERUvbC7BAltiwCfXY8XO8RFULSJXYwNpy_MYklROntrN4x-AGnIWT4fBKkViwsMYaf_P_8vyEvAL2DhhTVxlAMWgYrwf4btfoZ-QMup1oeKvh-dO9E6fkZc73jEklBbwgp6IFzriUZ-T77Tq7MsbZBhrX4uKEmSZbBky0DHamtbOE0dmNyXRJuB9doUuMiQ5oQxmahMEW3NOH1YaxHGj0NIweqS109_PHFOcyZGp9qYop9rE0NucxbxPJVrFqvKSYS9VwJU6HC3Libch4-VjPydfbmy_XH5u7zx8-Xb-_a5xQsjSqw95723qLEqUCD9BjXyvy3vleghN7zYTuWq8VoKwrYdzqDcGOtUqck7dH3er-sGIuZhqzwxDsjHHNhsuWKc4Y0xV98w96H9dUV1YpDZ0CJfVG8SPl6ndyQm-WNE42HQwwswVmjoGZGpj5HZjZhl4_Sq_9hPunkT8JVUAcgVyf5m-Y_nr_R_YX6gek-A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918717599</pqid></control><display><type>article</type><title>Functional outcomes rather than complications predict poor health-related quality of life at 6 months after robot-assisted radical prostatectomy</title><source>MEDLINE</source><source>ProQuest Central (Alumni Edition)</source><source>Springer Nature - Complete Springer Journals</source><source>ProQuest Central UK/Ireland</source><source>ProQuest Central</source><creator>Hagens, Marinus J. ; Veerman, H. ; de Ligt, K. M. ; Tillier, C. N. ; van Leeuwen, P. J. ; van Moorselaar, R. J. A. ; van der Poel, H. G.</creator><creatorcontrib>Hagens, Marinus J. ; Veerman, H. ; de Ligt, K. M. ; Tillier, C. N. ; van Leeuwen, P. J. ; van Moorselaar, R. J. A. ; van der Poel, H. G.</creatorcontrib><description>The objective is to evaluate the effect of robot-assisted radical prostatectomy (RARP)-related postoperative complications on the 6-month postoperative health-related quality of life (HRQoL). A total of 1008 patients underwent a RARP with or without pelvic lymph node dissection (PLND) between 2012 and 2020 and were invited to complete questionnaires about HRQoL and functional outcomes (urinary incontinence (UI), erectile dysfunction (ED) and urinary complaints (UC)) before and 6 months after RARP. Patient characteristics and postoperative complications up to 90 days after surgery were prospectively recorded. Associations between complications and HRQoL/functional outcomes were assessed by multivariate linear regression analyses. In total, 528 patients (52.4%) were included in the analyses. Complications occurred in 165/528 (31.3%) patients, of which 30/165 (18.2%) had a Clavien–Dindo ≥ III complication. In multivariate regression analyses, postoperative complications were not significantly associated with postoperative HRQoL, UI and ED (
p
= 0.73,
p
= 0.72 and
p
= 0.95, respectively), but were significantly associated with a minor increase in UC (β = 1.7,
p
< 0.001). More specifically, infectious and urological complications were significantly associated with an increase in UC (β = 1.9,
p
< 0.001 and β = 0.9,
p
= 0.004, respectively). The presence of UTI, in particular, was significantly associated with this minor increase (β = 1.5,
p
= 0.002). Functional outcomes were all significantly associated with the HRQoL at 6 months postoperatively. No significant associations were found between postoperative complications and HRQoL at 6 months after RARP. However, worse functional outcomes were associated with a worse HRQoL at 6 months postoperatively. In addition, postoperative infectious and urological complications were significantly associated with a minor increase in UC.</description><identifier>ISSN: 1863-2483</identifier><identifier>EISSN: 1863-2491</identifier><identifier>DOI: 10.1007/s11701-021-01266-9</identifier><identifier>PMID: 34120255</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Abdominal surgery ; Anemia ; Body mass index ; Cancer therapies ; Classification ; Comorbidity ; Diabetes ; Erectile dysfunction ; Humans ; Lymphatic system ; Male ; Medicine ; Medicine & Public Health ; Minimally Invasive Surgery ; Multivariate analysis ; Original Article ; Patients ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Prostate cancer ; Prostatectomy - adverse effects ; Quality of Life ; Questionnaires ; Radiation ; Regression analysis ; Robotic Surgical Procedures - methods ; Robotics ; Robots ; Surgery ; Treatment Outcome ; Urinary incontinence ; Urinary Incontinence - epidemiology ; Urinary Incontinence - etiology ; Urological surgery ; Urology ; Variables</subject><ispartof>Journal of robotic surgery, 2022-04, Vol.16 (2), p.453-462</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-78ebffa4fae5e571f11beb71fe2bcfb51c3d903984f971e524902a9eb71e80473</citedby><cites>FETCH-LOGICAL-c375t-78ebffa4fae5e571f11beb71fe2bcfb51c3d903984f971e524902a9eb71e80473</cites><orcidid>0000-0001-6699-0201</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11701-021-01266-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918717599?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,21369,21370,27905,27906,33511,33512,33725,33726,41469,42538,43640,43786,51300,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34120255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hagens, Marinus J.</creatorcontrib><creatorcontrib>Veerman, H.</creatorcontrib><creatorcontrib>de Ligt, K. M.</creatorcontrib><creatorcontrib>Tillier, C. N.</creatorcontrib><creatorcontrib>van Leeuwen, P. J.</creatorcontrib><creatorcontrib>van Moorselaar, R. J. A.</creatorcontrib><creatorcontrib>van der Poel, H. G.</creatorcontrib><title>Functional outcomes rather than complications predict poor health-related quality of life at 6 months after robot-assisted radical prostatectomy</title><title>Journal of robotic surgery</title><addtitle>J Robotic Surg</addtitle><addtitle>J Robot Surg</addtitle><description>The objective is to evaluate the effect of robot-assisted radical prostatectomy (RARP)-related postoperative complications on the 6-month postoperative health-related quality of life (HRQoL). A total of 1008 patients underwent a RARP with or without pelvic lymph node dissection (PLND) between 2012 and 2020 and were invited to complete questionnaires about HRQoL and functional outcomes (urinary incontinence (UI), erectile dysfunction (ED) and urinary complaints (UC)) before and 6 months after RARP. Patient characteristics and postoperative complications up to 90 days after surgery were prospectively recorded. Associations between complications and HRQoL/functional outcomes were assessed by multivariate linear regression analyses. In total, 528 patients (52.4%) were included in the analyses. Complications occurred in 165/528 (31.3%) patients, of which 30/165 (18.2%) had a Clavien–Dindo ≥ III complication. In multivariate regression analyses, postoperative complications were not significantly associated with postoperative HRQoL, UI and ED (
p
= 0.73,
p
= 0.72 and
p
= 0.95, respectively), but were significantly associated with a minor increase in UC (β = 1.7,
p
< 0.001). More specifically, infectious and urological complications were significantly associated with an increase in UC (β = 1.9,
p
< 0.001 and β = 0.9,
p
= 0.004, respectively). The presence of UTI, in particular, was significantly associated with this minor increase (β = 1.5,
p
= 0.002). Functional outcomes were all significantly associated with the HRQoL at 6 months postoperatively. No significant associations were found between postoperative complications and HRQoL at 6 months after RARP. However, worse functional outcomes were associated with a worse HRQoL at 6 months postoperatively. In addition, postoperative infectious and urological complications were significantly associated with a minor increase in UC.</description><subject>Abdominal surgery</subject><subject>Anemia</subject><subject>Body mass index</subject><subject>Cancer therapies</subject><subject>Classification</subject><subject>Comorbidity</subject><subject>Diabetes</subject><subject>Erectile dysfunction</subject><subject>Humans</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally Invasive Surgery</subject><subject>Multivariate analysis</subject><subject>Original Article</subject><subject>Patients</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Prostate cancer</subject><subject>Prostatectomy - adverse effects</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Radiation</subject><subject>Regression analysis</subject><subject>Robotic Surgical Procedures - methods</subject><subject>Robotics</subject><subject>Robots</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Urinary incontinence</subject><subject>Urinary Incontinence - epidemiology</subject><subject>Urinary Incontinence - etiology</subject><subject>Urological surgery</subject><subject>Urology</subject><subject>Variables</subject><issn>1863-2483</issn><issn>1863-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kUFu1TAQhi1ERUvbC7BAltiwCfXY8XO8RFULSJXYwNpy_MYklROntrN4x-AGnIWT4fBKkViwsMYaf_P_8vyEvAL2DhhTVxlAMWgYrwf4btfoZ-QMup1oeKvh-dO9E6fkZc73jEklBbwgp6IFzriUZ-T77Tq7MsbZBhrX4uKEmSZbBky0DHamtbOE0dmNyXRJuB9doUuMiQ5oQxmahMEW3NOH1YaxHGj0NIweqS109_PHFOcyZGp9qYop9rE0NucxbxPJVrFqvKSYS9VwJU6HC3Libch4-VjPydfbmy_XH5u7zx8-Xb-_a5xQsjSqw95723qLEqUCD9BjXyvy3vleghN7zYTuWq8VoKwrYdzqDcGOtUqck7dH3er-sGIuZhqzwxDsjHHNhsuWKc4Y0xV98w96H9dUV1YpDZ0CJfVG8SPl6ndyQm-WNE42HQwwswVmjoGZGpj5HZjZhl4_Sq_9hPunkT8JVUAcgVyf5m-Y_nr_R_YX6gek-A</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Hagens, Marinus J.</creator><creator>Veerman, H.</creator><creator>de Ligt, K. M.</creator><creator>Tillier, C. N.</creator><creator>van Leeuwen, P. J.</creator><creator>van Moorselaar, R. J. A.</creator><creator>van der Poel, H. G.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M7S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6699-0201</orcidid></search><sort><creationdate>202204</creationdate><title>Functional outcomes rather than complications predict poor health-related quality of life at 6 months after robot-assisted radical prostatectomy</title><author>Hagens, Marinus J. ; Veerman, H. ; de Ligt, K. M. ; Tillier, C. N. ; van Leeuwen, P. J. ; van Moorselaar, R. J. A. ; van der Poel, H. 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M.</creatorcontrib><creatorcontrib>Tillier, C. N.</creatorcontrib><creatorcontrib>van Leeuwen, P. J.</creatorcontrib><creatorcontrib>van Moorselaar, R. J. A.</creatorcontrib><creatorcontrib>van der Poel, H. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Engineering Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of robotic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hagens, Marinus J.</au><au>Veerman, H.</au><au>de Ligt, K. M.</au><au>Tillier, C. N.</au><au>van Leeuwen, P. J.</au><au>van Moorselaar, R. J. A.</au><au>van der Poel, H. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional outcomes rather than complications predict poor health-related quality of life at 6 months after robot-assisted radical prostatectomy</atitle><jtitle>Journal of robotic surgery</jtitle><stitle>J Robotic Surg</stitle><addtitle>J Robot Surg</addtitle><date>2022-04</date><risdate>2022</risdate><volume>16</volume><issue>2</issue><spage>453</spage><epage>462</epage><pages>453-462</pages><issn>1863-2483</issn><eissn>1863-2491</eissn><abstract>The objective is to evaluate the effect of robot-assisted radical prostatectomy (RARP)-related postoperative complications on the 6-month postoperative health-related quality of life (HRQoL). A total of 1008 patients underwent a RARP with or without pelvic lymph node dissection (PLND) between 2012 and 2020 and were invited to complete questionnaires about HRQoL and functional outcomes (urinary incontinence (UI), erectile dysfunction (ED) and urinary complaints (UC)) before and 6 months after RARP. Patient characteristics and postoperative complications up to 90 days after surgery were prospectively recorded. Associations between complications and HRQoL/functional outcomes were assessed by multivariate linear regression analyses. In total, 528 patients (52.4%) were included in the analyses. Complications occurred in 165/528 (31.3%) patients, of which 30/165 (18.2%) had a Clavien–Dindo ≥ III complication. In multivariate regression analyses, postoperative complications were not significantly associated with postoperative HRQoL, UI and ED (
p
= 0.73,
p
= 0.72 and
p
= 0.95, respectively), but were significantly associated with a minor increase in UC (β = 1.7,
p
< 0.001). More specifically, infectious and urological complications were significantly associated with an increase in UC (β = 1.9,
p
< 0.001 and β = 0.9,
p
= 0.004, respectively). The presence of UTI, in particular, was significantly associated with this minor increase (β = 1.5,
p
= 0.002). Functional outcomes were all significantly associated with the HRQoL at 6 months postoperatively. No significant associations were found between postoperative complications and HRQoL at 6 months after RARP. However, worse functional outcomes were associated with a worse HRQoL at 6 months postoperatively. In addition, postoperative infectious and urological complications were significantly associated with a minor increase in UC.</abstract><cop>London</cop><pub>Springer London</pub><pmid>34120255</pmid><doi>10.1007/s11701-021-01266-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6699-0201</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of robotic surgery, 2022-04, Vol.16 (2), p.453-462 |
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| source | MEDLINE; ProQuest Central (Alumni Edition); Springer Nature - Complete Springer Journals; ProQuest Central UK/Ireland; ProQuest Central |
| subjects | Abdominal surgery Anemia Body mass index Cancer therapies Classification Comorbidity Diabetes Erectile dysfunction Humans Lymphatic system Male Medicine Medicine & Public Health Minimally Invasive Surgery Multivariate analysis Original Article Patients Postoperative Complications - epidemiology Postoperative Complications - etiology Prostate cancer Prostatectomy - adverse effects Quality of Life Questionnaires Radiation Regression analysis Robotic Surgical Procedures - methods Robotics Robots Surgery Treatment Outcome Urinary incontinence Urinary Incontinence - epidemiology Urinary Incontinence - etiology Urological surgery Urology Variables |
| title | Functional outcomes rather than complications predict poor health-related quality of life at 6 months after robot-assisted radical prostatectomy |
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