Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients
•Coexisting immune-mediated diseases (IMDs) were identified in 1 out of 6 patients with sarcoidosis.•The frequency of immune-mediated disease (IMDs) in our patients with sarcoidosis was 1.64-fold higher than that reported in general population.•Women with sarcoidosis have a two-fold higher frequency...
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| Veröffentlicht in: | Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2021-12, Vol.88 (6), p.105236-105236, Article 105236 |
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| creator | Brito-Zerón, Pilar Pérez-Alvarez, Roberto Feijoo-Massó, Carles Gracia-Tello, Borja González-García, Andres Gómez-de-la-Torre, Ricardo Alguacil, Ana López-Dupla, Miguel Robles, Angel Garcia-Morillo, Salvador Bonet, Mariona Cruz-Caparrós, Gracia Fonseca-Aizpuru, Eva Akasbi, Miriam Callejas, Jose Luis de Miguel-Campo, Borja Pérez-de-Lis, Marta Ramos-Casals, Manuel De-Escalante, B. Chara-Cervantes, J. Pérez-Conesa, M. Rascón, J. Pallarés, L. Perez-Guerrero, P. De-la-Red, G. Calvo, E. Soler, C. Peral-Gutiérrez, E. Gómez-Cerezo, J.F. Rodríguez-Fernández, S. Pinilla, B. Toledo-Samaniego, N. Gato, A. Chamorro, A.J. Morcillo, C. Ojeda, I. Vives, M.J. de-Miguel, B. Penadés, M. De-Vicente, M. |
| description | •Coexisting immune-mediated diseases (IMDs) were identified in 1 out of 6 patients with sarcoidosis.•The frequency of immune-mediated disease (IMDs) in our patients with sarcoidosis was 1.64-fold higher than that reported in general population.•Women with sarcoidosis have a two-fold higher frequency of concomitant IMDs.•We identify 5 key IMDs strongly associated with sarcoidosis (primary immunodeficiencies, systemic autoimmune diseases, inflammatory arthritis, autoimmune liver diseases and autoimmune cytopenias).•Search for coexisting IMDs in patients with sarcoidosis presenting with features considered out of the clinical extrathoracic scenario typical of sarcoidosis.•There was a wide variety of both systemic and organ-specific diseases coexisting with sarcoidosis.
To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.
We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population.
Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49–2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5years, P5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjögren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considera |
| doi_str_mv | 10.1016/j.jbspin.2021.105236 |
| format | Article |
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To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.
We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population.
Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49–2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5years, P<0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44–1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoidosis (OR>5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjögren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considerably higher than crude ORs for eosinophilic digestive disease in women, and for immune thrombocytopenia, systemic sclerosis and autoimmune hepatitis in men.
We found coexisting IMDs in 1 out of 6 patients with sarcoidosis. The strongest associations were found for immunodeficiencies and some systemic, rheumatic, hepatic and hematological autoimmune diseases.</description><identifier>ISSN: 1297-319X</identifier><identifier>EISSN: 1778-7254</identifier><identifier>DOI: 10.1016/j.jbspin.2021.105236</identifier><identifier>PMID: 34116201</identifier><language>eng</language><publisher>ISSY-LES-MOULINEAUX: Elsevier Masson SAS</publisher><subject>Antiphospholipid syndrome ; Arthritis ; Autoimmune diseases ; Autoimmune hepatitis ; Cytopenias ; Immunodeficiencies ; Life Sciences & Biomedicine ; Primary biliary cholangitis ; Rheumatology ; Sarcoidosis ; Science & Technology ; Sjögren syndrome ; Systemic sclerosis</subject><ispartof>Joint, bone, spine : revue du rhumatisme, 2021-12, Vol.88 (6), p.105236-105236, Article 105236</ispartof><rights>2021 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>18</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000709047400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c385t-5aada02d67cc54b69879635edce7445d3d4a5caac023f0acf0ea37b1e9f943d83</citedby><cites>FETCH-LOGICAL-c385t-5aada02d67cc54b69879635edce7445d3d4a5caac023f0acf0ea37b1e9f943d83</cites><orcidid>0000-0003-1156-2570 ; 0000-0002-9141-2523 ; 0000-0001-7105-9470 ; 0000-0001-5709-6734 ; 0000-0002-2345-2873</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jbspin.2021.105236$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,39267,46004</link.rule.ids></links><search><creatorcontrib>Brito-Zerón, Pilar</creatorcontrib><creatorcontrib>Pérez-Alvarez, Roberto</creatorcontrib><creatorcontrib>Feijoo-Massó, Carles</creatorcontrib><creatorcontrib>Gracia-Tello, Borja</creatorcontrib><creatorcontrib>González-García, Andres</creatorcontrib><creatorcontrib>Gómez-de-la-Torre, Ricardo</creatorcontrib><creatorcontrib>Alguacil, Ana</creatorcontrib><creatorcontrib>López-Dupla, Miguel</creatorcontrib><creatorcontrib>Robles, Angel</creatorcontrib><creatorcontrib>Garcia-Morillo, Salvador</creatorcontrib><creatorcontrib>Bonet, Mariona</creatorcontrib><creatorcontrib>Cruz-Caparrós, Gracia</creatorcontrib><creatorcontrib>Fonseca-Aizpuru, Eva</creatorcontrib><creatorcontrib>Akasbi, Miriam</creatorcontrib><creatorcontrib>Callejas, Jose Luis</creatorcontrib><creatorcontrib>de Miguel-Campo, Borja</creatorcontrib><creatorcontrib>Pérez-de-Lis, Marta</creatorcontrib><creatorcontrib>Ramos-Casals, Manuel</creatorcontrib><creatorcontrib>De-Escalante, B.</creatorcontrib><creatorcontrib>Chara-Cervantes, J.</creatorcontrib><creatorcontrib>Pérez-Conesa, M.</creatorcontrib><creatorcontrib>Rascón, J.</creatorcontrib><creatorcontrib>Pallarés, L.</creatorcontrib><creatorcontrib>Perez-Guerrero, P.</creatorcontrib><creatorcontrib>De-la-Red, G.</creatorcontrib><creatorcontrib>Calvo, E.</creatorcontrib><creatorcontrib>Soler, C.</creatorcontrib><creatorcontrib>Peral-Gutiérrez, E.</creatorcontrib><creatorcontrib>Gómez-Cerezo, J.F.</creatorcontrib><creatorcontrib>Rodríguez-Fernández, S.</creatorcontrib><creatorcontrib>Pinilla, B.</creatorcontrib><creatorcontrib>Toledo-Samaniego, N.</creatorcontrib><creatorcontrib>Gato, A.</creatorcontrib><creatorcontrib>Chamorro, A.J.</creatorcontrib><creatorcontrib>Morcillo, C.</creatorcontrib><creatorcontrib>Ojeda, I.</creatorcontrib><creatorcontrib>Vives, M.J.</creatorcontrib><creatorcontrib>de-Miguel, B.</creatorcontrib><creatorcontrib>Penadés, M.</creatorcontrib><creatorcontrib>De-Vicente, M.</creatorcontrib><creatorcontrib>The SarcoGEAS-SEMI Registry</creatorcontrib><title>Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients</title><title>Joint, bone, spine : revue du rhumatisme</title><addtitle>JOINT BONE SPINE</addtitle><description>•Coexisting immune-mediated diseases (IMDs) were identified in 1 out of 6 patients with sarcoidosis.•The frequency of immune-mediated disease (IMDs) in our patients with sarcoidosis was 1.64-fold higher than that reported in general population.•Women with sarcoidosis have a two-fold higher frequency of concomitant IMDs.•We identify 5 key IMDs strongly associated with sarcoidosis (primary immunodeficiencies, systemic autoimmune diseases, inflammatory arthritis, autoimmune liver diseases and autoimmune cytopenias).•Search for coexisting IMDs in patients with sarcoidosis presenting with features considered out of the clinical extrathoracic scenario typical of sarcoidosis.•There was a wide variety of both systemic and organ-specific diseases coexisting with sarcoidosis.
To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.
We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population.
Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49–2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5years, P<0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44–1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoidosis (OR>5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjögren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considerably higher than crude ORs for eosinophilic digestive disease in women, and for immune thrombocytopenia, systemic sclerosis and autoimmune hepatitis in men.
We found coexisting IMDs in 1 out of 6 patients with sarcoidosis. The strongest associations were found for immunodeficiencies and some systemic, rheumatic, hepatic and hematological autoimmune diseases.</description><subject>Antiphospholipid syndrome</subject><subject>Arthritis</subject><subject>Autoimmune diseases</subject><subject>Autoimmune hepatitis</subject><subject>Cytopenias</subject><subject>Immunodeficiencies</subject><subject>Life Sciences & Biomedicine</subject><subject>Primary biliary cholangitis</subject><subject>Rheumatology</subject><subject>Sarcoidosis</subject><subject>Science & Technology</subject><subject>Sjögren syndrome</subject><subject>Systemic sclerosis</subject><issn>1297-319X</issn><issn>1778-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkE2L1EAQhoMo7rr6Dzz0UZCM_ZlOLoIEV4UFLwremp7uitSQdI-pHnX_vR2yeBRP9VK8T1E8TfNS8IPgontzOpyOdMZ0kFyKujJSdY-aa2Ft31pp9OOa5WBbJYZvV80zohPnXEnTPW2ulBaik1xcN_OY4TdSgRSA5YnhslwStAtE9AUii0jgCYhhYuTXkDFmQjqw2xV-XCp1z3yKLMyYMPiZEX5PONW43auMsMqysy8IqdDz5snkZ4IXD_Om-Xr7_sv4sb37_OHT-O6uDao3pTXeR89l7GwIRh-7obdDpwzEAFZrE1XU3gTvA5dq4j5MHLyyRwHDNGgVe3XTvNrvntdcn6TiFqQA8-wT5Au5aqfqktpsVb1Xw5qJVpjcecXFr_dOcLd5die3e3abZ7d7rli_Y7_gmCcKuPn7i1bRlg9cW10TFyOWKiCnMV9Sqejr_0dr--3ehurrJ8LqHoiIK4TiYsZ_f_oH-NGorQ</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Brito-Zerón, Pilar</creator><creator>Pérez-Alvarez, Roberto</creator><creator>Feijoo-Massó, Carles</creator><creator>Gracia-Tello, Borja</creator><creator>González-García, Andres</creator><creator>Gómez-de-la-Torre, Ricardo</creator><creator>Alguacil, Ana</creator><creator>López-Dupla, Miguel</creator><creator>Robles, Angel</creator><creator>Garcia-Morillo, Salvador</creator><creator>Bonet, Mariona</creator><creator>Cruz-Caparrós, Gracia</creator><creator>Fonseca-Aizpuru, Eva</creator><creator>Akasbi, Miriam</creator><creator>Callejas, Jose Luis</creator><creator>de Miguel-Campo, Borja</creator><creator>Pérez-de-Lis, Marta</creator><creator>Ramos-Casals, Manuel</creator><creator>De-Escalante, B.</creator><creator>Chara-Cervantes, J.</creator><creator>Pérez-Conesa, M.</creator><creator>Rascón, J.</creator><creator>Pallarés, L.</creator><creator>Perez-Guerrero, P.</creator><creator>De-la-Red, G.</creator><creator>Calvo, E.</creator><creator>Soler, C.</creator><creator>Peral-Gutiérrez, E.</creator><creator>Gómez-Cerezo, J.F.</creator><creator>Rodríguez-Fernández, S.</creator><creator>Pinilla, B.</creator><creator>Toledo-Samaniego, N.</creator><creator>Gato, A.</creator><creator>Chamorro, A.J.</creator><creator>Morcillo, C.</creator><creator>Ojeda, I.</creator><creator>Vives, M.J.</creator><creator>de-Miguel, B.</creator><creator>Penadés, M.</creator><creator>De-Vicente, M.</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1156-2570</orcidid><orcidid>https://orcid.org/0000-0002-9141-2523</orcidid><orcidid>https://orcid.org/0000-0001-7105-9470</orcidid><orcidid>https://orcid.org/0000-0001-5709-6734</orcidid><orcidid>https://orcid.org/0000-0002-2345-2873</orcidid></search><sort><creationdate>202112</creationdate><title>Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients</title><author>Brito-Zerón, Pilar ; Pérez-Alvarez, Roberto ; Feijoo-Massó, Carles ; Gracia-Tello, Borja ; González-García, Andres ; Gómez-de-la-Torre, Ricardo ; Alguacil, Ana ; López-Dupla, Miguel ; Robles, Angel ; Garcia-Morillo, Salvador ; Bonet, Mariona ; Cruz-Caparrós, Gracia ; Fonseca-Aizpuru, Eva ; Akasbi, Miriam ; Callejas, Jose Luis ; de Miguel-Campo, Borja ; Pérez-de-Lis, Marta ; Ramos-Casals, Manuel ; De-Escalante, B. ; Chara-Cervantes, J. ; Pérez-Conesa, M. ; Rascón, J. ; Pallarés, L. ; Perez-Guerrero, P. ; De-la-Red, G. ; Calvo, E. ; Soler, C. ; Peral-Gutiérrez, E. ; Gómez-Cerezo, J.F. ; Rodríguez-Fernández, S. ; Pinilla, B. ; Toledo-Samaniego, N. ; Gato, A. ; Chamorro, A.J. ; Morcillo, C. ; Ojeda, I. ; Vives, M.J. ; de-Miguel, B. ; Penadés, M. ; De-Vicente, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-5aada02d67cc54b69879635edce7445d3d4a5caac023f0acf0ea37b1e9f943d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antiphospholipid syndrome</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Autoimmune hepatitis</topic><topic>Cytopenias</topic><topic>Immunodeficiencies</topic><topic>Life Sciences & Biomedicine</topic><topic>Primary biliary cholangitis</topic><topic>Rheumatology</topic><topic>Sarcoidosis</topic><topic>Science & Technology</topic><topic>Sjögren syndrome</topic><topic>Systemic sclerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brito-Zerón, Pilar</creatorcontrib><creatorcontrib>Pérez-Alvarez, Roberto</creatorcontrib><creatorcontrib>Feijoo-Massó, Carles</creatorcontrib><creatorcontrib>Gracia-Tello, Borja</creatorcontrib><creatorcontrib>González-García, Andres</creatorcontrib><creatorcontrib>Gómez-de-la-Torre, Ricardo</creatorcontrib><creatorcontrib>Alguacil, Ana</creatorcontrib><creatorcontrib>López-Dupla, Miguel</creatorcontrib><creatorcontrib>Robles, Angel</creatorcontrib><creatorcontrib>Garcia-Morillo, Salvador</creatorcontrib><creatorcontrib>Bonet, Mariona</creatorcontrib><creatorcontrib>Cruz-Caparrós, Gracia</creatorcontrib><creatorcontrib>Fonseca-Aizpuru, Eva</creatorcontrib><creatorcontrib>Akasbi, Miriam</creatorcontrib><creatorcontrib>Callejas, Jose Luis</creatorcontrib><creatorcontrib>de Miguel-Campo, Borja</creatorcontrib><creatorcontrib>Pérez-de-Lis, Marta</creatorcontrib><creatorcontrib>Ramos-Casals, Manuel</creatorcontrib><creatorcontrib>De-Escalante, B.</creatorcontrib><creatorcontrib>Chara-Cervantes, J.</creatorcontrib><creatorcontrib>Pérez-Conesa, M.</creatorcontrib><creatorcontrib>Rascón, J.</creatorcontrib><creatorcontrib>Pallarés, L.</creatorcontrib><creatorcontrib>Perez-Guerrero, P.</creatorcontrib><creatorcontrib>De-la-Red, G.</creatorcontrib><creatorcontrib>Calvo, E.</creatorcontrib><creatorcontrib>Soler, C.</creatorcontrib><creatorcontrib>Peral-Gutiérrez, E.</creatorcontrib><creatorcontrib>Gómez-Cerezo, J.F.</creatorcontrib><creatorcontrib>Rodríguez-Fernández, S.</creatorcontrib><creatorcontrib>Pinilla, B.</creatorcontrib><creatorcontrib>Toledo-Samaniego, N.</creatorcontrib><creatorcontrib>Gato, A.</creatorcontrib><creatorcontrib>Chamorro, A.J.</creatorcontrib><creatorcontrib>Morcillo, C.</creatorcontrib><creatorcontrib>Ojeda, I.</creatorcontrib><creatorcontrib>Vives, M.J.</creatorcontrib><creatorcontrib>de-Miguel, B.</creatorcontrib><creatorcontrib>Penadés, M.</creatorcontrib><creatorcontrib>De-Vicente, M.</creatorcontrib><creatorcontrib>The SarcoGEAS-SEMI Registry</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brito-Zerón, Pilar</au><au>Pérez-Alvarez, Roberto</au><au>Feijoo-Massó, Carles</au><au>Gracia-Tello, Borja</au><au>González-García, Andres</au><au>Gómez-de-la-Torre, Ricardo</au><au>Alguacil, Ana</au><au>López-Dupla, Miguel</au><au>Robles, Angel</au><au>Garcia-Morillo, Salvador</au><au>Bonet, Mariona</au><au>Cruz-Caparrós, Gracia</au><au>Fonseca-Aizpuru, Eva</au><au>Akasbi, Miriam</au><au>Callejas, Jose Luis</au><au>de Miguel-Campo, Borja</au><au>Pérez-de-Lis, Marta</au><au>Ramos-Casals, Manuel</au><au>De-Escalante, B.</au><au>Chara-Cervantes, J.</au><au>Pérez-Conesa, M.</au><au>Rascón, J.</au><au>Pallarés, L.</au><au>Perez-Guerrero, P.</au><au>De-la-Red, G.</au><au>Calvo, E.</au><au>Soler, C.</au><au>Peral-Gutiérrez, E.</au><au>Gómez-Cerezo, J.F.</au><au>Rodríguez-Fernández, S.</au><au>Pinilla, B.</au><au>Toledo-Samaniego, N.</au><au>Gato, A.</au><au>Chamorro, A.J.</au><au>Morcillo, C.</au><au>Ojeda, I.</au><au>Vives, M.J.</au><au>de-Miguel, B.</au><au>Penadés, M.</au><au>De-Vicente, M.</au><aucorp>The SarcoGEAS-SEMI Registry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients</atitle><jtitle>Joint, bone, spine : revue du rhumatisme</jtitle><stitle>JOINT BONE SPINE</stitle><date>2021-12</date><risdate>2021</risdate><volume>88</volume><issue>6</issue><spage>105236</spage><epage>105236</epage><pages>105236-105236</pages><artnum>105236</artnum><issn>1297-319X</issn><eissn>1778-7254</eissn><abstract>•Coexisting immune-mediated diseases (IMDs) were identified in 1 out of 6 patients with sarcoidosis.•The frequency of immune-mediated disease (IMDs) in our patients with sarcoidosis was 1.64-fold higher than that reported in general population.•Women with sarcoidosis have a two-fold higher frequency of concomitant IMDs.•We identify 5 key IMDs strongly associated with sarcoidosis (primary immunodeficiencies, systemic autoimmune diseases, inflammatory arthritis, autoimmune liver diseases and autoimmune cytopenias).•Search for coexisting IMDs in patients with sarcoidosis presenting with features considered out of the clinical extrathoracic scenario typical of sarcoidosis.•There was a wide variety of both systemic and organ-specific diseases coexisting with sarcoidosis.
To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease.
We searched for coexisting IMDs in patients included in the SARCOGEAS-cohort, a multicenter nationwide database of consecutive patients diagnosed according to the ATS/ESC/WASOG criteria. Comparisons were made considering the presence or absence of IMD clustering, and odds ratios (OR) and their 95% confidence intervals (CI) were calculated as the ratio of observed cases of every IMD in the sarcoidosis cohort to the observed cases in the general population.
Among 1737 patients with sarcoidosis, 283 (16%) patients presented at least one associated IMD. These patients were more commonly female (OR: 1.98, 95% CI: 1.49–2.62) and were diagnosed with sarcoidosis at an older age (49.6 vs. 47.5years, P<0.05). The frequency of IMDs in patients with sarcoidosis was nearly 2-fold higher than the frequency observed in the general population (OR: 1.64, 95% CI: 1.44–1.86). Significant associations were identified in 17 individual IMDs. In comparison with the general population, the IMDs with the strongest strength of association with sarcoidosis (OR>5) were common variable immunodeficiency (CVID) (OR: 431.8), familial Mediterranean fever (OR 33.9), primary biliary cholangitis (OR: 16.57), haemolytic anemia (OR: 12.17), autoimmune hepatitis (OR: 9.01), antiphospholipid syndrome (OR: 8.70), immune thrombocytopenia (OR: 8.43), Sjögren syndrome (OR: 6.98), systemic sclerosis (OR: 5.71), ankylosing spondylitis (OR: 5.49), IgA deficiency (OR: 5.07) and psoriatic arthritis (OR: 5.06). Sex-adjusted ORs were considerably higher than crude ORs for eosinophilic digestive disease in women, and for immune thrombocytopenia, systemic sclerosis and autoimmune hepatitis in men.
We found coexisting IMDs in 1 out of 6 patients with sarcoidosis. The strongest associations were found for immunodeficiencies and some systemic, rheumatic, hepatic and hematological autoimmune diseases.</abstract><cop>ISSY-LES-MOULINEAUX</cop><pub>Elsevier Masson SAS</pub><pmid>34116201</pmid><doi>10.1016/j.jbspin.2021.105236</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1156-2570</orcidid><orcidid>https://orcid.org/0000-0002-9141-2523</orcidid><orcidid>https://orcid.org/0000-0001-7105-9470</orcidid><orcidid>https://orcid.org/0000-0001-5709-6734</orcidid><orcidid>https://orcid.org/0000-0002-2345-2873</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1297-319X |
| ispartof | Joint, bone, spine : revue du rhumatisme, 2021-12, Vol.88 (6), p.105236-105236, Article 105236 |
| issn | 1297-319X 1778-7254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2540522458 |
| source | Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via ScienceDirect (Elsevier) |
| subjects | Antiphospholipid syndrome Arthritis Autoimmune diseases Autoimmune hepatitis Cytopenias Immunodeficiencies Life Sciences & Biomedicine Primary biliary cholangitis Rheumatology Sarcoidosis Science & Technology Sjögren syndrome Systemic sclerosis |
| title | Coexistence of immune-mediated diseases in sarcoidosis. Frequency and clinical significance in 1737 patients |
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