BAG3 epigenetically regulates GALNT10 expression via WDR5 and facilitates the stem cell-like properties of platin-resistant ovarian cancer cells

Ovarian cancer is the most lethal gynecologic malignant cancer, frequently due to its late diagnosis and high recurrence. Cancer stem cells (CSCs) from different malignancies including ovarian cancer have been linked to chemotherapy resistance and poor prognosis. Therefore, identifying the molecular...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2021-08, Vol.1868 (9), p.119077-119077, Article 119077
Hauptverfasser:	Zhao, Fu-Ying, Zhang, Qi, Wang, Jia-Mei, Jiang, Jing-Yi, Huyan, Ling-Yue, Liu, Bao-Qin, Yan, Jing, Li, Chao, Wang, Hua-Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Antineoplastic Agents - pharmacology Apoptosis Regulatory Proteins - deficiency Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism BAG3 Cancer stem cells Carboplatin - pharmacology Drug Resistance, Neoplasm - drug effects Epigenesis, Genetic - genetics Female GALNT10 Humans Intracellular Signaling Peptides and Proteins - metabolism N-Acetylgalactosaminyltransferases - deficiency N-Acetylgalactosaminyltransferases - genetics N-Acetylgalactosaminyltransferases - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Polypeptide N-acetylgalactosaminyltransferase Tumor Cells, Cultured WDR5
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