Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum–mitochondria miscommunication

Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated cardiovascular dysfunction and increased platelet P2Y12 receptor activation. Although P2Y12 receptor antagonist ticagrelor (Tica) plays roles in re...

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Veröffentlicht in:	Molecular and cellular biochemistry 2021-10, Vol.476 (10), p.3827-3844
Hauptverfasser:	Olgar, Yusuf, Durak, Aysegul, Degirmenci, Sinan, Tuncay, Erkan, Billur, Deniz, Ozdemir, Semir, Turan, Belma
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biochemistry Biomedical and Life Sciences Calcium channels Calcium ions Carbohydrates Cardiology Cardiomyocytes Cardiovascular diseases Dietary Carbohydrates - adverse effects Dietary Carbohydrates - pharmacology Health risks Heart cells High carbohydrate diet Hyperglycemia Ion Transport - drug effects Life Sciences Male Medical Biochemistry Metabolic disorders Metabolic syndrome Metabolic Syndrome - chemically induced Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Mitochondria Mitochondria, Heart - metabolism Mitochondria, Heart - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Na+/Ca2+ exchanger Oncology Oxidative stress Phagosomes Phospholamban Phosphorylation Potassium channels (voltage-gated) Rats Rats, Wistar Receptor mechanisms Receptors Ryanodine receptors Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - pathology Signal Transduction - drug effects Sodium channels (voltage-gated) Structure-function relationships Ticagrelor Ticagrelor - pharmacology Ventricle
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