MEG3 lncRNA is over-expressed in autism spectrum disorder

MEG3 lncRNA is over-expressed in autism spectrum disorder

Long non-coding RNAs (lncRNAs) comprise a group of regulatory transcripts which partake in the biological processes leading to development of neuropsychiatric disorders such as autism spectrum disorder (ASD). We measured circulatory levels of MEG3 , GAS5 , CYTOR , UCA1 lncRNAs and CRYBG3 gene in chi...

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Veröffentlicht in:Metabolic brain disease 2021-12, Vol.36 (8), p.2235-2242
Hauptverfasser: Taheri, Mohammad, Honarmand Tamizkar, Kasra, Omrani, Shaghayegh, Arsang-Jang, Shahram, Ghafouri-Fard, Soudeh, Omrani, Mir Davood
Format: Artikel
Sprache:eng
Schlagworte:
Autism
Autism Spectrum Disorder - genetics
Biochemistry
Biological activity
Biomedical and Life Sciences
Biomedicine
Child
Children
Correlation coefficient
Correlation coefficients
Female
Humans
Male
Males
Mental disorders
Metabolic Diseases
Neurology
Neurosciences
Non-coding RNA
Oncology
Original Article
Pathogenesis
RNA, Long Noncoding - metabolism
ROC Curve
Subgroups
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Zusammenfassung:Long non-coding RNAs (lncRNAs) comprise a group of regulatory transcripts which partake in the biological processes leading to development of neuropsychiatric disorders such as autism spectrum disorder (ASD). We measured circulatory levels of MEG3 , GAS5 , CYTOR , UCA1 lncRNAs and CRYBG3 gene in children with ASD and controls. Expression of MEG3 was remarkably higher in children with ASD when compared with controls (Posterior Beta = 2.919, SE = 0.51, P value 
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-021-00764-x