Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer
Recently, we pioneered the application of Cherenkov radiation (CR) of radionuclides for the in situ excitation of discrete Eu(III) and Tb(III) complexes. CR is produced by isotopes decaying under emission of charged particles in dielectric media and exhibits a maximum intensity below 400 nm. We ha...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Chemical Society 2021-06, Vol.143 (24), p.9206-9214 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9214 |
|---|---|
| container_issue | 24 |
| container_start_page | 9206 |
| container_title | Journal of the American Chemical Society |
| container_volume | 143 |
| creator | Martin, Kirsten E Cosby, Alexia G Boros, Eszter |
| description | Recently, we pioneered the application of Cherenkov radiation (CR) of radionuclides for the in situ excitation of discrete Eu(III) and Tb(III) complexes. CR is produced by isotopes decaying under emission of charged particles in dielectric media and exhibits a maximum intensity below 400 nm. We have demonstrated that luminescent lanthanide antenna complexes are ideal acceptors for Cherenkov radiation-mediated energy transfer (CRET). Here, we develop and assess peptide-functionalized Tb(III) and Eu(III) complexes in conjunction with CRET excitation by the positron emissive radioisotope 18F for simultaneous, multiplexed imaging and in vivo optical imaging. This work demonstrates, for the first time, that the detection of the luminescence emission of a discrete Eu(III) complex in vivo is feasible. Our results open possibilities for discrete luminescent lanthanide complexes to be used as diagnostic, optical tools for the intrasurgical guidance of tumor resection. |
| doi_str_mv | 10.1021/jacs.1c04264 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2540515520</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2540515520</sourcerecordid><originalsourceid>FETCH-LOGICAL-a362t-5daa0788b835dee574ae08d452f2af156c569fefa5ce7c49993648a2db36d1ca3</originalsourceid><addsrcrecordid>eNptkcFO3DAQhi3Uqmxpb5wrH3toqO3Y2eSItku70iIkClyjiT1ZvE3sxXYQ-xp94iZiCxdOHkvffKOZn5BTzs44E_z7FnQ845pJUcgjMuNKsExxUbwjM8aYyOZlkR-TjzFux68UJf9AjnPJuSxZNSN_L4cu2V2HTxScoStH7-yjp1e7ZDV0dNXDxroN9S39YaMOmJCuh946jBpdomtw6R6cNUgXvp80GOnSQdOhoc1-8v22aaCLewzo_vhHeg3GQrLe0UucqpFbOgybPb0J4GKL4RN530IX8fPhPSG3F8ubxa9sffVztThfZ5AXImXKALB5WTZlrgyimktAVhqpRCug5arQqqhabEFpnGtZVVVeyBKEafLCcA35Cfn67N0F_zBgTHU_rohdBw79EGuhJFNcjfcc0W_PqA4-xoBtvQu2h7CvOaunFOophfqQwoh_OZiHpkfzAv8_--voqWvrh-DGRd92_QOk4pJM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2540515520</pqid></control><display><type>article</type><title>Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer</title><source>MEDLINE</source><source>ACS Publications</source><creator>Martin, Kirsten E ; Cosby, Alexia G ; Boros, Eszter</creator><creatorcontrib>Martin, Kirsten E ; Cosby, Alexia G ; Boros, Eszter</creatorcontrib><description>Recently, we pioneered the application of Cherenkov radiation (CR) of radionuclides for the in situ excitation of discrete Eu(III) and Tb(III) complexes. CR is produced by isotopes decaying under emission of charged particles in dielectric media and exhibits a maximum intensity below 400 nm. We have demonstrated that luminescent lanthanide antenna complexes are ideal acceptors for Cherenkov radiation-mediated energy transfer (CRET). Here, we develop and assess peptide-functionalized Tb(III) and Eu(III) complexes in conjunction with CRET excitation by the positron emissive radioisotope 18F for simultaneous, multiplexed imaging and in vivo optical imaging. This work demonstrates, for the first time, that the detection of the luminescence emission of a discrete Eu(III) complex in vivo is feasible. Our results open possibilities for discrete luminescent lanthanide complexes to be used as diagnostic, optical tools for the intrasurgical guidance of tumor resection.</description><identifier>ISSN: 0002-7863</identifier><identifier>EISSN: 1520-5126</identifier><identifier>DOI: 10.1021/jacs.1c04264</identifier><identifier>PMID: 34114809</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Cell Line, Tumor ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Energy Transfer ; Lanthanoid Series Elements - chemistry ; Ligands ; Male ; Mice ; Mice, Nude ; Molecular Conformation ; Neoplasms, Experimental - diagnostic imaging ; Optical Imaging ; Peptides - chemistry</subject><ispartof>Journal of the American Chemical Society, 2021-06, Vol.143 (24), p.9206-9214</ispartof><rights>2021 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a362t-5daa0788b835dee574ae08d452f2af156c569fefa5ce7c49993648a2db36d1ca3</citedby><cites>FETCH-LOGICAL-a362t-5daa0788b835dee574ae08d452f2af156c569fefa5ce7c49993648a2db36d1ca3</cites><orcidid>0000-0002-4186-6586 ; 0000-0002-2222-3497</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jacs.1c04264$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jacs.1c04264$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34114809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Kirsten E</creatorcontrib><creatorcontrib>Cosby, Alexia G</creatorcontrib><creatorcontrib>Boros, Eszter</creatorcontrib><title>Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer</title><title>Journal of the American Chemical Society</title><addtitle>J. Am. Chem. Soc</addtitle><description>Recently, we pioneered the application of Cherenkov radiation (CR) of radionuclides for the in situ excitation of discrete Eu(III) and Tb(III) complexes. CR is produced by isotopes decaying under emission of charged particles in dielectric media and exhibits a maximum intensity below 400 nm. We have demonstrated that luminescent lanthanide antenna complexes are ideal acceptors for Cherenkov radiation-mediated energy transfer (CRET). Here, we develop and assess peptide-functionalized Tb(III) and Eu(III) complexes in conjunction with CRET excitation by the positron emissive radioisotope 18F for simultaneous, multiplexed imaging and in vivo optical imaging. This work demonstrates, for the first time, that the detection of the luminescence emission of a discrete Eu(III) complex in vivo is feasible. Our results open possibilities for discrete luminescent lanthanide complexes to be used as diagnostic, optical tools for the intrasurgical guidance of tumor resection.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Coordination Complexes - chemical synthesis</subject><subject>Coordination Complexes - chemistry</subject><subject>Energy Transfer</subject><subject>Lanthanoid Series Elements - chemistry</subject><subject>Ligands</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Molecular Conformation</subject><subject>Neoplasms, Experimental - diagnostic imaging</subject><subject>Optical Imaging</subject><subject>Peptides - chemistry</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFO3DAQhi3Uqmxpb5wrH3toqO3Y2eSItku70iIkClyjiT1ZvE3sxXYQ-xp94iZiCxdOHkvffKOZn5BTzs44E_z7FnQ845pJUcgjMuNKsExxUbwjM8aYyOZlkR-TjzFux68UJf9AjnPJuSxZNSN_L4cu2V2HTxScoStH7-yjp1e7ZDV0dNXDxroN9S39YaMOmJCuh946jBpdomtw6R6cNUgXvp80GOnSQdOhoc1-8v22aaCLewzo_vhHeg3GQrLe0UucqpFbOgybPb0J4GKL4RN530IX8fPhPSG3F8ubxa9sffVztThfZ5AXImXKALB5WTZlrgyimktAVhqpRCug5arQqqhabEFpnGtZVVVeyBKEafLCcA35Cfn67N0F_zBgTHU_rohdBw79EGuhJFNcjfcc0W_PqA4-xoBtvQu2h7CvOaunFOophfqQwoh_OZiHpkfzAv8_--voqWvrh-DGRd92_QOk4pJM</recordid><startdate>20210623</startdate><enddate>20210623</enddate><creator>Martin, Kirsten E</creator><creator>Cosby, Alexia G</creator><creator>Boros, Eszter</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4186-6586</orcidid><orcidid>https://orcid.org/0000-0002-2222-3497</orcidid></search><sort><creationdate>20210623</creationdate><title>Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer</title><author>Martin, Kirsten E ; Cosby, Alexia G ; Boros, Eszter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a362t-5daa0788b835dee574ae08d452f2af156c569fefa5ce7c49993648a2db36d1ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Coordination Complexes - chemical synthesis</topic><topic>Coordination Complexes - chemistry</topic><topic>Energy Transfer</topic><topic>Lanthanoid Series Elements - chemistry</topic><topic>Ligands</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Molecular Conformation</topic><topic>Neoplasms, Experimental - diagnostic imaging</topic><topic>Optical Imaging</topic><topic>Peptides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Kirsten E</creatorcontrib><creatorcontrib>Cosby, Alexia G</creatorcontrib><creatorcontrib>Boros, Eszter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Kirsten E</au><au>Cosby, Alexia G</au><au>Boros, Eszter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2021-06-23</date><risdate>2021</risdate><volume>143</volume><issue>24</issue><spage>9206</spage><epage>9214</epage><pages>9206-9214</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>Recently, we pioneered the application of Cherenkov radiation (CR) of radionuclides for the in situ excitation of discrete Eu(III) and Tb(III) complexes. CR is produced by isotopes decaying under emission of charged particles in dielectric media and exhibits a maximum intensity below 400 nm. We have demonstrated that luminescent lanthanide antenna complexes are ideal acceptors for Cherenkov radiation-mediated energy transfer (CRET). Here, we develop and assess peptide-functionalized Tb(III) and Eu(III) complexes in conjunction with CRET excitation by the positron emissive radioisotope 18F for simultaneous, multiplexed imaging and in vivo optical imaging. This work demonstrates, for the first time, that the detection of the luminescence emission of a discrete Eu(III) complex in vivo is feasible. Our results open possibilities for discrete luminescent lanthanide complexes to be used as diagnostic, optical tools for the intrasurgical guidance of tumor resection.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>34114809</pmid><doi>10.1021/jacs.1c04264</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4186-6586</orcidid><orcidid>https://orcid.org/0000-0002-2222-3497</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 2021-06, Vol.143 (24), p.9206-9214 |
| issn | 0002-7863 1520-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2540515520 |
| source | MEDLINE; ACS Publications |
| subjects | Animals Cell Line, Tumor Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Energy Transfer Lanthanoid Series Elements - chemistry Ligands Male Mice Mice, Nude Molecular Conformation Neoplasms, Experimental - diagnostic imaging Optical Imaging Peptides - chemistry |
| title | Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T04%3A53%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multiplex%20and%20In%20Vivo%20Optical%20Imaging%20of%20Discrete%20Luminescent%20Lanthanide%20Complexes%20Enabled%20by%20In%20Situ%20Cherenkov%20Radiation%20Mediated%20Energy%20Transfer&rft.jtitle=Journal%20of%20the%20American%20Chemical%20Society&rft.au=Martin,%20Kirsten%20E&rft.date=2021-06-23&rft.volume=143&rft.issue=24&rft.spage=9206&rft.epage=9214&rft.pages=9206-9214&rft.issn=0002-7863&rft.eissn=1520-5126&rft_id=info:doi/10.1021/jacs.1c04264&rft_dat=%3Cproquest_cross%3E2540515520%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2540515520&rft_id=info:pmid/34114809&rfr_iscdi=true |