COL11A1 activates cancer-associated fibroblasts by modulating TGF-β3 through the NF-κB/IGFBP2 axis in ovarian cancer cells

Ovarian cancer has a unique tumor microenvironment (TME) that enables cancer-associated fibroblasts (CAFs) to interact with cellular and matrix constituents and influence tumor development and migration into the peritoneal cavity. Collagen type XI alpha 1 (COL11A1) is overexpressed in CAFs; therefor...

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Veröffentlicht in:	Oncogene 2021-07, Vol.40 (26), p.4503-4519
Hauptverfasser:	Wu, Yi-Hui, Huang, Yu-Fang, Chang, Tzu-Hao, Chen, Chien-Chin, Wu, Pei-Ying, Huang, Soon-Cen, Chou, Cheng-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/89 14/34 14/63 38/1 631/67/1517/1709 631/67/327 631/80/86 64 64/60 82 96 96/21 Animals Apoptosis Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Carcinoma, Ovarian Epithelial - metabolism Carcinoma, Ovarian Epithelial - pathology Cell activation Cell Biology Cell proliferation Cell Proliferation - physiology Collagen Collagen Type XI - metabolism Extracellular signal-regulated kinase Female Fibroblasts Human Genetics Humans Insulin Insulin-Like Growth Factor Binding Protein 2 - metabolism Insulin-like growth factor-binding protein 2 Interleukin 6 Internal Medicine Invasiveness Kinases Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, SCID NF-kappa B - metabolism NF-κB protein Oncology Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Ovary - metabolism Ovary - pathology Peritoneum Phenotypes Signal Transduction - physiology Sp1 protein Transforming Growth Factor beta3 - metabolism Tumor microenvironment Tumor Microenvironment - physiology Tumors
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