Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Life sciences (1973) 2021-02, Vol.267, p.118975-118975, Article 118975
Hauptverfasser:	Thapa, Komal, Khan, Heena, Sharma, Uma, Grewal, Amarjot Kaur, Singh, Thakur Gurjeet
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Alzheimer disease Alzheimer's disease Amyotrophic lateral sclerosis Animals Apoptosis ASK-JNK signalling Caspases Cell death Central Nervous System Diseases - drug therapy Central Nervous System Diseases - metabolism Damage death Deoxyribonucleic acid Depletion DNA DNA damage drugs enzymes Humans Huntington's disease Inhibitors Literature reviews Molecular Targeted Therapy Mortality Movement disorders NAD Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - enzymology Neurodegenerative Diseases - metabolism neurons NF-κB signalling Parkinson disease Parkinson's disease PARP (poly (ADP-ribose) polymerase) PARP-1 inhibitors Parthanatos Pathogenesis PI3K signalling Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Ribose stroke Therapeutic targets therapeutics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!