Neonatal administration of kaempferol does not alter satiety but increases somatic growth and reduces adiposity in offspring of high-fat diet dams
The aim of this study was to evaluate the effects of maternal exposure to a high-fat diet associated with neonatal administration of kaempferol on somatic growth, biochemical profile and feeding behavior in offspring. Wistar rats were distributed according to diet during pregnancy and lactation into...
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| Veröffentlicht in: | Life sciences (1973) 2020-10, Vol.259, p.118224-118224, Article 118224 |
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| container_title | Life sciences (1973) |
| container_volume | 259 |
| creator | Chaves, Wenicios Ferreira Pinheiro, Isabeli Lins da Silva, Luana Olegário Lima-Oliveira, Débora Priscila Muniz, Gisélia de Santana Barreto, Álvaro do Nascimento da Silva, Breno José Manhães-de-Castro, Raul da Silva Aragão, Raquel |
| description | The aim of this study was to evaluate the effects of maternal exposure to a high-fat diet associated with neonatal administration of kaempferol on somatic growth, biochemical profile and feeding behavior in offspring.
Wistar rats were distributed according to diet during pregnancy and lactation into Control (C; 3.4 kcal/g; 12% kcal/lipids) or High-fat (HFD; 4.6 kcal/g; 51% kcal/lipids) groups. In the offspring, vehicle (V) or kaempferol (K, 1 mg/kg) were administered from the 8th until the 21st postnatal day (PND). Maternal body weight (BW), caloric intake and adiposity were measured. In the offspring, somatic growth parameters were evaluated on the 7th, 14th, 21st, 25th and 30th PND, except for BW, which was measured from the 8th to the 21st and from the 25th to the 30th PND. Feeding behavior was assessed by food intake and behavioral satiety sequence (BSS) on the 30th PND. The biochemical profile and relative weight of adipose tissue of offspring were also measured.
Dams exposed to HFD showed no difference in body weight and caloric intake but exhibited increased adiposity. Neonatal administration of kaempferol increased body weight after weaning and somatic growth in the offspring of HFD dams. Neonatal kaempferol also reduced adiposity and serum creatinine levels in offspring. Neither maternal diet nor kaempferol altered offspring feeding behavior.
Neonatal administration of kaempferol promotes increased somatic growth post-weaning, reduces adiposity, and does not alter feeding behavior in offspring from high-fat dams. |
| doi_str_mv | 10.1016/j.lfs.2020.118224 |
| format | Article |
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Wistar rats were distributed according to diet during pregnancy and lactation into Control (C; 3.4 kcal/g; 12% kcal/lipids) or High-fat (HFD; 4.6 kcal/g; 51% kcal/lipids) groups. In the offspring, vehicle (V) or kaempferol (K, 1 mg/kg) were administered from the 8th until the 21st postnatal day (PND). Maternal body weight (BW), caloric intake and adiposity were measured. In the offspring, somatic growth parameters were evaluated on the 7th, 14th, 21st, 25th and 30th PND, except for BW, which was measured from the 8th to the 21st and from the 25th to the 30th PND. Feeding behavior was assessed by food intake and behavioral satiety sequence (BSS) on the 30th PND. The biochemical profile and relative weight of adipose tissue of offspring were also measured.
Dams exposed to HFD showed no difference in body weight and caloric intake but exhibited increased adiposity. Neonatal administration of kaempferol increased body weight after weaning and somatic growth in the offspring of HFD dams. Neonatal kaempferol also reduced adiposity and serum creatinine levels in offspring. Neither maternal diet nor kaempferol altered offspring feeding behavior.
Neonatal administration of kaempferol promotes increased somatic growth post-weaning, reduces adiposity, and does not alter feeding behavior in offspring from high-fat dams.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2020.118224</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Adipose tissue ; adiposity ; Animal behavior ; Behavioral satiety sequence ; Biochemical profile ; blood serum ; Body weight ; Creatinine ; Diet ; energy intake ; Evaluation ; Feeding behavior ; Food intake ; High fat diet ; Kaempferol ; Lactation ; Lipids ; maternal exposure ; maternal nutrition ; Maternal programming ; Neonates ; Offspring ; Phenolic compounds ; Physical growth ; pregnancy ; progeny ; Satiety ; Weaning</subject><ispartof>Life sciences (1973), 2020-10, Vol.259, p.118224-118224, Article 118224</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright Elsevier BV Oct 15, 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-7478447555cece7b401cfa12be8ca4e0bdfb1144f6b47909948c3e3acf13b9a93</citedby><cites>FETCH-LOGICAL-c434t-7478447555cece7b401cfa12be8ca4e0bdfb1144f6b47909948c3e3acf13b9a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320520309760$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Chaves, Wenicios Ferreira</creatorcontrib><creatorcontrib>Pinheiro, Isabeli Lins</creatorcontrib><creatorcontrib>da Silva, Luana Olegário</creatorcontrib><creatorcontrib>Lima-Oliveira, Débora Priscila</creatorcontrib><creatorcontrib>Muniz, Gisélia de Santana</creatorcontrib><creatorcontrib>Barreto, Álvaro do Nascimento</creatorcontrib><creatorcontrib>da Silva, Breno José</creatorcontrib><creatorcontrib>Manhães-de-Castro, Raul</creatorcontrib><creatorcontrib>da Silva Aragão, Raquel</creatorcontrib><title>Neonatal administration of kaempferol does not alter satiety but increases somatic growth and reduces adiposity in offspring of high-fat diet dams</title><title>Life sciences (1973)</title><description>The aim of this study was to evaluate the effects of maternal exposure to a high-fat diet associated with neonatal administration of kaempferol on somatic growth, biochemical profile and feeding behavior in offspring.
Wistar rats were distributed according to diet during pregnancy and lactation into Control (C; 3.4 kcal/g; 12% kcal/lipids) or High-fat (HFD; 4.6 kcal/g; 51% kcal/lipids) groups. In the offspring, vehicle (V) or kaempferol (K, 1 mg/kg) were administered from the 8th until the 21st postnatal day (PND). Maternal body weight (BW), caloric intake and adiposity were measured. In the offspring, somatic growth parameters were evaluated on the 7th, 14th, 21st, 25th and 30th PND, except for BW, which was measured from the 8th to the 21st and from the 25th to the 30th PND. Feeding behavior was assessed by food intake and behavioral satiety sequence (BSS) on the 30th PND. The biochemical profile and relative weight of adipose tissue of offspring were also measured.
Dams exposed to HFD showed no difference in body weight and caloric intake but exhibited increased adiposity. Neonatal administration of kaempferol increased body weight after weaning and somatic growth in the offspring of HFD dams. Neonatal kaempferol also reduced adiposity and serum creatinine levels in offspring. Neither maternal diet nor kaempferol altered offspring feeding behavior.
Neonatal administration of kaempferol promotes increased somatic growth post-weaning, reduces adiposity, and does not alter feeding behavior in offspring from high-fat dams.</description><subject>Adipose tissue</subject><subject>adiposity</subject><subject>Animal behavior</subject><subject>Behavioral satiety sequence</subject><subject>Biochemical profile</subject><subject>blood serum</subject><subject>Body weight</subject><subject>Creatinine</subject><subject>Diet</subject><subject>energy intake</subject><subject>Evaluation</subject><subject>Feeding behavior</subject><subject>Food intake</subject><subject>High fat diet</subject><subject>Kaempferol</subject><subject>Lactation</subject><subject>Lipids</subject><subject>maternal exposure</subject><subject>maternal nutrition</subject><subject>Maternal programming</subject><subject>Neonates</subject><subject>Offspring</subject><subject>Phenolic compounds</subject><subject>Physical growth</subject><subject>pregnancy</subject><subject>progeny</subject><subject>Satiety</subject><subject>Weaning</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkU-v1CAUxRujiePTD-COxI2bjlAu0zauzIv_khfd6JrcwmWGsYURqOZ9DT-xNOPKha4I3N85N5zTNM8F3wsuDq_O-9nlfce7ehdD18GDZieGfmz5QYqHzY7zDlrZcfW4eZLzmXOuVC93za9PFAMWnBnaxQefS8LiY2DRsW9Iy8VRijOzkTILsTCcCyWWK0Plnk1rYT6YRJjrPMelvht2TPFnOTEMliWyq6kjtP4Ss68Sv1m7fEk-HLclJ388tQ4Ls9WRWVzy0-aRwznTsz_nTfP13dsvtx_au8_vP96-uWsNSChtD_0A0CulDBnqJ-DCOBTdRINBID5ZNwkB4A4T9CMfRxiMJInGCTmNOMqb5uXV95Li95Vy0YvPhuYZA8U1604Bh0EJkP9HQdbQAWCo6Iu_0HNcU6gfqYZcgQChtt3iSpkUc07kdA1kwXSvBddbofqsa6F6K1RfC62a11cN1VB-eEo6G0_BkPWJTNE2-n-ofwNv86qe</recordid><startdate>20201015</startdate><enddate>20201015</enddate><creator>Chaves, Wenicios Ferreira</creator><creator>Pinheiro, Isabeli Lins</creator><creator>da Silva, Luana Olegário</creator><creator>Lima-Oliveira, Débora Priscila</creator><creator>Muniz, Gisélia de Santana</creator><creator>Barreto, Álvaro do Nascimento</creator><creator>da Silva, Breno José</creator><creator>Manhães-de-Castro, Raul</creator><creator>da Silva Aragão, Raquel</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20201015</creationdate><title>Neonatal administration of kaempferol does not alter satiety but increases somatic growth and reduces adiposity in offspring of high-fat diet dams</title><author>Chaves, Wenicios Ferreira ; Pinheiro, Isabeli Lins ; da Silva, Luana Olegário ; Lima-Oliveira, Débora Priscila ; Muniz, Gisélia de Santana ; Barreto, Álvaro do Nascimento ; da Silva, Breno José ; Manhães-de-Castro, Raul ; da Silva Aragão, Raquel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-7478447555cece7b401cfa12be8ca4e0bdfb1144f6b47909948c3e3acf13b9a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>adiposity</topic><topic>Animal behavior</topic><topic>Behavioral satiety sequence</topic><topic>Biochemical profile</topic><topic>blood serum</topic><topic>Body weight</topic><topic>Creatinine</topic><topic>Diet</topic><topic>energy intake</topic><topic>Evaluation</topic><topic>Feeding behavior</topic><topic>Food intake</topic><topic>High fat diet</topic><topic>Kaempferol</topic><topic>Lactation</topic><topic>Lipids</topic><topic>maternal exposure</topic><topic>maternal nutrition</topic><topic>Maternal programming</topic><topic>Neonates</topic><topic>Offspring</topic><topic>Phenolic compounds</topic><topic>Physical growth</topic><topic>pregnancy</topic><topic>progeny</topic><topic>Satiety</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaves, Wenicios Ferreira</creatorcontrib><creatorcontrib>Pinheiro, Isabeli Lins</creatorcontrib><creatorcontrib>da Silva, Luana Olegário</creatorcontrib><creatorcontrib>Lima-Oliveira, Débora Priscila</creatorcontrib><creatorcontrib>Muniz, Gisélia de Santana</creatorcontrib><creatorcontrib>Barreto, Álvaro do Nascimento</creatorcontrib><creatorcontrib>da Silva, Breno José</creatorcontrib><creatorcontrib>Manhães-de-Castro, Raul</creatorcontrib><creatorcontrib>da Silva Aragão, Raquel</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaves, Wenicios Ferreira</au><au>Pinheiro, Isabeli Lins</au><au>da Silva, Luana Olegário</au><au>Lima-Oliveira, Débora Priscila</au><au>Muniz, Gisélia de Santana</au><au>Barreto, Álvaro do Nascimento</au><au>da Silva, Breno José</au><au>Manhães-de-Castro, Raul</au><au>da Silva Aragão, Raquel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal administration of kaempferol does not alter satiety but increases somatic growth and reduces adiposity in offspring of high-fat diet dams</atitle><jtitle>Life sciences (1973)</jtitle><date>2020-10-15</date><risdate>2020</risdate><volume>259</volume><spage>118224</spage><epage>118224</epage><pages>118224-118224</pages><artnum>118224</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The aim of this study was to evaluate the effects of maternal exposure to a high-fat diet associated with neonatal administration of kaempferol on somatic growth, biochemical profile and feeding behavior in offspring.
Wistar rats were distributed according to diet during pregnancy and lactation into Control (C; 3.4 kcal/g; 12% kcal/lipids) or High-fat (HFD; 4.6 kcal/g; 51% kcal/lipids) groups. In the offspring, vehicle (V) or kaempferol (K, 1 mg/kg) were administered from the 8th until the 21st postnatal day (PND). Maternal body weight (BW), caloric intake and adiposity were measured. In the offspring, somatic growth parameters were evaluated on the 7th, 14th, 21st, 25th and 30th PND, except for BW, which was measured from the 8th to the 21st and from the 25th to the 30th PND. Feeding behavior was assessed by food intake and behavioral satiety sequence (BSS) on the 30th PND. The biochemical profile and relative weight of adipose tissue of offspring were also measured.
Dams exposed to HFD showed no difference in body weight and caloric intake but exhibited increased adiposity. Neonatal administration of kaempferol increased body weight after weaning and somatic growth in the offspring of HFD dams. Neonatal kaempferol also reduced adiposity and serum creatinine levels in offspring. Neither maternal diet nor kaempferol altered offspring feeding behavior.
Neonatal administration of kaempferol promotes increased somatic growth post-weaning, reduces adiposity, and does not alter feeding behavior in offspring from high-fat dams.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><doi>10.1016/j.lfs.2020.118224</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Life sciences (1973), 2020-10, Vol.259, p.118224-118224, Article 118224 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Adipose tissue adiposity Animal behavior Behavioral satiety sequence Biochemical profile blood serum Body weight Creatinine Diet energy intake Evaluation Feeding behavior Food intake High fat diet Kaempferol Lactation Lipids maternal exposure maternal nutrition Maternal programming Neonates Offspring Phenolic compounds Physical growth pregnancy progeny Satiety Weaning |
| title | Neonatal administration of kaempferol does not alter satiety but increases somatic growth and reduces adiposity in offspring of high-fat diet dams |
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