Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis

To investigate the possible modulatory effect of febuxostat in testosterone-induced benign prostatic hyperplasia (BPH) in rats with emphasis on xanthine oxidase (XO)/Janus Kinases (JAK)/signal transducer and activator of transcription (STAT) axis. Male Wistar rats were treated with testosterone with...

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Veröffentlicht in:	Life sciences (1973) 2020-11, Vol.260, p.118414-9, Article 118414
Hauptverfasser:	Abo-Youssef, Amira M., Afify, Hassan, Azouz, Amany A., Abdel-Rahman, Hanaa M., Abdel-Naim, Ashraf B., Allam, Shady
Format:	Artikel
Sprache:	eng
Schlagworte:	BAX protein Bcl-2 protein Benign prostatic hyperplasia blood serum Colorimetry Cyclin D1 cyclins Cytokines D1 protein Febuxostat Gene expression Glutathione Histopathology Hyperplasia IL-1β immunohistochemistry Inflammation Interleukin 1 Interleukin 6 Kinases males Malondialdehyde Markers NF-κB protein Oxidative stress Phosphorylation phosphotransferases (kinases) Polymerase chain reaction Prostate Protein expression protein synthesis Proteins Stat3 protein Superoxide dismutase Testosterone transactivators Transcription Tumor necrosis factor Tumor necrosis factor-TNF tumor necrosis factors Uric acid Weight Western blotting Xanthine oxidase
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