DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology

A novel DEK-AFF2 fusion has been recently identified in four cases of basaloid to nonkeratinizing squamous cell carcinoma (SCC) in the sinonasal tract and middle ear with high-grade morphology. The exceptional response to immune checkpoint inhibitor in the first reported case highlights the potentia...

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Veröffentlicht in:	Modern pathology 2021-10, Vol.34 (10), p.1820-1830
Hauptverfasser:	Kuo, Ying-Ju, Lewis, James S., Zhai, Changwen, Chen, Yun-An, Chernock, Rebecca D., Hsieh, Min-Shu, Lan, Ming-Ying, Lee, Chien-Kuan, Weinreb, Ilan, Hang, Jen-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	14/32 45/77 631/67/1536 692/699/67/1536 82/51 Adult Aged Cancer Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Cell fusion Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Dysplasia Female Fluorescence in situ hybridization Fronds Gene rearrangement Human papillomavirus Humans Immune checkpoint inhibitors In Situ Hybridization, Fluorescence Laboratory Medicine Leukocytes (neutrophilic) Lymph nodes Male Medicine Medicine & Public Health Metastases Middle Aged Middle ear Morphology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncogene Proteins - genetics Oncogene Proteins - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Papilloma Pathology Poly-ADP-Ribose Binding Proteins - genetics Poly-ADP-Ribose Binding Proteins - metabolism Polymerase chain reaction Reverse transcription Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Squamous Cell Carcinoma of Head and Neck - metabolism Squamous Cell Carcinoma of Head and Neck - pathology Terminology Tumors
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