Prenatal evaluation of functional pulmonary hypoplasia via fetal magnetic resonance imaging
Objective The purpose of this study was to retrospectively examine the use of lung‐to‐liver signal intensity ratio (LLSIR) on T2‐weighted images to predict functional pulmonary hypoplasia. Methods The subjects of this study were pregnant women who underwent magnetic resonance imaging (MRI). Patients...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2021-09, Vol.47 (9), p.3100-3106 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Sakuma, Junya Nakata, Masahiko Takano, Mayumi Nagasaki, Sumito Hayata, Eijiro Maemura, Toshimitsu Ohtsu, Motoharu Morita, Mineto |
| description | Objective
The purpose of this study was to retrospectively examine the use of lung‐to‐liver signal intensity ratio (LLSIR) on T2‐weighted images to predict functional pulmonary hypoplasia.
Methods
The subjects of this study were pregnant women who underwent magnetic resonance imaging (MRI). Patients who required nitric oxide inhalation and those who died from respiratory disorders were classified as having functional pulmonary hypoplasia (FPH). All other cases were presented as the control group. We retrospectively analyzed MRI and perinatal data. LLSIR was defined as the ratio of lung signal intensity to liver signal intensity. We examined the relationship between LLSIR and gestational age, compared the LLSIRs in the two groups, and calculated the best cut‐off value of the LLSIR to predict FPH.
Results
One hundred and ninety‐one patients were eligible for this study, and 12 cases were classified as having FPH. In the control group, LLSIR increased with age (r = 0.383, p |
| doi_str_mv | 10.1111/jog.14833 |
| format | Article |
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The purpose of this study was to retrospectively examine the use of lung‐to‐liver signal intensity ratio (LLSIR) on T2‐weighted images to predict functional pulmonary hypoplasia.
Methods
The subjects of this study were pregnant women who underwent magnetic resonance imaging (MRI). Patients who required nitric oxide inhalation and those who died from respiratory disorders were classified as having functional pulmonary hypoplasia (FPH). All other cases were presented as the control group. We retrospectively analyzed MRI and perinatal data. LLSIR was defined as the ratio of lung signal intensity to liver signal intensity. We examined the relationship between LLSIR and gestational age, compared the LLSIRs in the two groups, and calculated the best cut‐off value of the LLSIR to predict FPH.
Results
One hundred and ninety‐one patients were eligible for this study, and 12 cases were classified as having FPH. In the control group, LLSIR increased with age (r = 0.383, p < 0.001). We used the observed/expected LLSIR (o/e LLSIR), which was the ratio of obtained LLSIR to expected LLSIR calculated by the regression line to correct the effect of gestational age. In the FHP group, o/e LLSIR was significantly lower than in the control group (p < 0.001). A receiver operating characteristic curve analysis showed that cases with o/e LLSIR above 0.85 were less likely to cause FPH.
Conclusions
Low o/e LLSIR might reflect the histological characteristics of hypoplastic lung structures. O/e LLSIR seems to be a useful MRI parameter for screening FPH.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14833</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Age ; fetal MRI ; Fetuses ; Gestational age ; Hypoplasia ; Inhalation ; Liver ; Magnetic resonance imaging ; Nitric oxide ; pregnancy ; prenatal diagnosis ; pulmonary hypoplasia ; respiratory disorder</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-09, Vol.47 (9), p.3100-3106</ispartof><rights>2021 Japan Society of Obstetrics and Gynecology.</rights><rights>2021 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4383-6880a7c7c4863360c2fb16b5800a1a2463a870e33eaff1e4578972c6495d1cf03</citedby><cites>FETCH-LOGICAL-c4383-6880a7c7c4863360c2fb16b5800a1a2463a870e33eaff1e4578972c6495d1cf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.14833$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.14833$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Sakuma, Junya</creatorcontrib><creatorcontrib>Nakata, Masahiko</creatorcontrib><creatorcontrib>Takano, Mayumi</creatorcontrib><creatorcontrib>Nagasaki, Sumito</creatorcontrib><creatorcontrib>Hayata, Eijiro</creatorcontrib><creatorcontrib>Maemura, Toshimitsu</creatorcontrib><creatorcontrib>Ohtsu, Motoharu</creatorcontrib><creatorcontrib>Morita, Mineto</creatorcontrib><title>Prenatal evaluation of functional pulmonary hypoplasia via fetal magnetic resonance imaging</title><title>The journal of obstetrics and gynaecology research</title><description>Objective
The purpose of this study was to retrospectively examine the use of lung‐to‐liver signal intensity ratio (LLSIR) on T2‐weighted images to predict functional pulmonary hypoplasia.
Methods
The subjects of this study were pregnant women who underwent magnetic resonance imaging (MRI). Patients who required nitric oxide inhalation and those who died from respiratory disorders were classified as having functional pulmonary hypoplasia (FPH). All other cases were presented as the control group. We retrospectively analyzed MRI and perinatal data. LLSIR was defined as the ratio of lung signal intensity to liver signal intensity. We examined the relationship between LLSIR and gestational age, compared the LLSIRs in the two groups, and calculated the best cut‐off value of the LLSIR to predict FPH.
Results
One hundred and ninety‐one patients were eligible for this study, and 12 cases were classified as having FPH. In the control group, LLSIR increased with age (r = 0.383, p < 0.001). We used the observed/expected LLSIR (o/e LLSIR), which was the ratio of obtained LLSIR to expected LLSIR calculated by the regression line to correct the effect of gestational age. In the FHP group, o/e LLSIR was significantly lower than in the control group (p < 0.001). A receiver operating characteristic curve analysis showed that cases with o/e LLSIR above 0.85 were less likely to cause FPH.
Conclusions
Low o/e LLSIR might reflect the histological characteristics of hypoplastic lung structures. O/e LLSIR seems to be a useful MRI parameter for screening FPH.</description><subject>Age</subject><subject>fetal MRI</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Hypoplasia</subject><subject>Inhalation</subject><subject>Liver</subject><subject>Magnetic resonance imaging</subject><subject>Nitric oxide</subject><subject>pregnancy</subject><subject>prenatal diagnosis</subject><subject>pulmonary hypoplasia</subject><subject>respiratory disorder</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kMFLwzAUxoMoOKcH_4OCFz10S5o0SY8ydCqDedCTh5LFl9qRNTVZJ_3vTa0nwUB4H8nve4_vIXRJ8IzEM9-6akaYpPQITQhjIsUi58dRU0ZSiQU_RWchbDEmoiBygt6ePTRqr2wCB2U7ta9dkziTmK7Rg44fbWd3Ufg--ehb11oVapUc4jUw-HaqamBf68RDiFijIanjW91U5-jEKBvg4rdO0ev93cviIV2tl4-L21WqGZU05VJiJbTQTHJKOdaZ2RC-ySXGiqiMcaqkwEApKGMIsFzIQmSasyJ_J9pgOkXXY9_Wu88Owr7c1UGDtaoB14Uyy2kRZ1CcRfTqD7p1nY8pB4pLWrBYInUzUtq7EDyYsvUxk-9LgsthzdFVlT9rjux8ZL9qC_3_YPm0Xo6ObwWQfnQ</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Sakuma, Junya</creator><creator>Nakata, Masahiko</creator><creator>Takano, Mayumi</creator><creator>Nagasaki, Sumito</creator><creator>Hayata, Eijiro</creator><creator>Maemura, Toshimitsu</creator><creator>Ohtsu, Motoharu</creator><creator>Morita, Mineto</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202109</creationdate><title>Prenatal evaluation of functional pulmonary hypoplasia via fetal magnetic resonance imaging</title><author>Sakuma, Junya ; Nakata, Masahiko ; Takano, Mayumi ; Nagasaki, Sumito ; Hayata, Eijiro ; Maemura, Toshimitsu ; Ohtsu, Motoharu ; Morita, Mineto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4383-6880a7c7c4863360c2fb16b5800a1a2463a870e33eaff1e4578972c6495d1cf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>fetal MRI</topic><topic>Fetuses</topic><topic>Gestational age</topic><topic>Hypoplasia</topic><topic>Inhalation</topic><topic>Liver</topic><topic>Magnetic resonance imaging</topic><topic>Nitric oxide</topic><topic>pregnancy</topic><topic>prenatal diagnosis</topic><topic>pulmonary hypoplasia</topic><topic>respiratory disorder</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakuma, Junya</creatorcontrib><creatorcontrib>Nakata, Masahiko</creatorcontrib><creatorcontrib>Takano, Mayumi</creatorcontrib><creatorcontrib>Nagasaki, Sumito</creatorcontrib><creatorcontrib>Hayata, Eijiro</creatorcontrib><creatorcontrib>Maemura, Toshimitsu</creatorcontrib><creatorcontrib>Ohtsu, Motoharu</creatorcontrib><creatorcontrib>Morita, Mineto</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakuma, Junya</au><au>Nakata, Masahiko</au><au>Takano, Mayumi</au><au>Nagasaki, Sumito</au><au>Hayata, Eijiro</au><au>Maemura, Toshimitsu</au><au>Ohtsu, Motoharu</au><au>Morita, Mineto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal evaluation of functional pulmonary hypoplasia via fetal magnetic resonance imaging</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><date>2021-09</date><risdate>2021</risdate><volume>47</volume><issue>9</issue><spage>3100</spage><epage>3106</epage><pages>3100-3106</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Objective
The purpose of this study was to retrospectively examine the use of lung‐to‐liver signal intensity ratio (LLSIR) on T2‐weighted images to predict functional pulmonary hypoplasia.
Methods
The subjects of this study were pregnant women who underwent magnetic resonance imaging (MRI). Patients who required nitric oxide inhalation and those who died from respiratory disorders were classified as having functional pulmonary hypoplasia (FPH). All other cases were presented as the control group. We retrospectively analyzed MRI and perinatal data. LLSIR was defined as the ratio of lung signal intensity to liver signal intensity. We examined the relationship between LLSIR and gestational age, compared the LLSIRs in the two groups, and calculated the best cut‐off value of the LLSIR to predict FPH.
Results
One hundred and ninety‐one patients were eligible for this study, and 12 cases were classified as having FPH. In the control group, LLSIR increased with age (r = 0.383, p < 0.001). We used the observed/expected LLSIR (o/e LLSIR), which was the ratio of obtained LLSIR to expected LLSIR calculated by the regression line to correct the effect of gestational age. In the FHP group, o/e LLSIR was significantly lower than in the control group (p < 0.001). A receiver operating characteristic curve analysis showed that cases with o/e LLSIR above 0.85 were less likely to cause FPH.
Conclusions
Low o/e LLSIR might reflect the histological characteristics of hypoplastic lung structures. O/e LLSIR seems to be a useful MRI parameter for screening FPH.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><doi>10.1111/jog.14833</doi><tpages>7</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Age fetal MRI Fetuses Gestational age Hypoplasia Inhalation Liver Magnetic resonance imaging Nitric oxide pregnancy prenatal diagnosis pulmonary hypoplasia respiratory disorder |
| title | Prenatal evaluation of functional pulmonary hypoplasia via fetal magnetic resonance imaging |
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