Toxoplasma gondii infection by serological and molecular methods in schizophrenia patients with and without suicide attempts: An age‐sex‐matched case‐control study
Introduction The opinion that latent Toxoplasma gondii infection is having a broadly asymptomatic projection has now been interrogated, in specific due to the echoed association between the latent infection and an elevated incidence of schizophrenia or even suicide attempts. Notwithstanding conducte...
Gespeichert in:
| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-08, Vol.75 (8), p.e14449-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 8 |
| container_start_page | e14449 |
| container_title | International journal of clinical practice (Esher) |
| container_volume | 75 |
| creator | Akgül, Özer Demirel, Ömer Faruk Aksoy Poyraz, Cana Tanriöver Aydin, Ezgi Uysal, Nuray Bulu, Ersel Sapmaz, Burcu Çalişkan, Reyhan Öner, Yaşar Ali |
| description | Introduction
The opinion that latent Toxoplasma gondii infection is having a broadly asymptomatic projection has now been interrogated, in specific due to the echoed association between the latent infection and an elevated incidence of schizophrenia or even suicide attempts. Notwithstanding conducted studies aimed to understand this feasible link are restricted.
Methods
In the present case‐control study, we focused to illuminate the relationship between the serological and molecular presence of T gondii and schizophrenia with or without the suicide attempts by comparing it with healthy individuals. A total of 237 participants (117 in schizophrenia and 120 in healthy control) were included in this study.
Results
Overall, latent T gondii infections were found statistically higher in 63 (53.8%) of the 117 patients with schizophrenia and in 33 (27.5%) of the 120 controls (P |
| doi_str_mv | 10.1111/ijcp.14449 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2539525213</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2539525213</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3709-11684dfa94046dabd457d0f398250f765741660cc4a93d95bda7eef1048153193</originalsourceid><addsrcrecordid>eNp90c1u1DAQB_AIUYnScuEJLHFBSCl2bOeDW7UqUFSpHMo58tqTjVeOHTyO2uXEI_AavBZPgtPlxKE-2CPrN2NL_6J4zegFy-u93ev5ggkhumfFKWtEVbJKsOe55nVbSsrZi-Il4p7SSsqWnha_78JDmJ3CSZFd8MZaYv0AOtngyfZAEGJwYWe1ckR5Q6bgQC9ORTJBGoPBzAnq0f4I8xjBW0VmlSz4hOTepvGxaS3CkgguVlsDRKUE05zwA7n0RO3gz89fCA95n1TSIxiiFa6XOviUnyeYFnM4L04G5RBe_TvPim8fr-42n8ub20_Xm8ubUvOGdiVjdSvMoDpBRW3U1gjZGDrwrq0kHZpaNoLVNdVaqI6bTm6NagAGRkXLJGcdPyveHufOMXxfAFM_WdTgnPIQFuwryTtZyYrxTN_8R_dhiT7_LivJhairblXvjkrHgBhh6OdoJxUPPaP9mlq_ptY_ppYxO-J76-DwhOyvv2y-Hnv-AtZEoEM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2553446293</pqid></control><display><type>article</type><title>Toxoplasma gondii infection by serological and molecular methods in schizophrenia patients with and without suicide attempts: An age‐sex‐matched case‐control study</title><source>Access via Wiley Online Library</source><creator>Akgül, Özer ; Demirel, Ömer Faruk ; Aksoy Poyraz, Cana ; Tanriöver Aydin, Ezgi ; Uysal, Nuray ; Bulu, Ersel ; Sapmaz, Burcu ; Çalişkan, Reyhan ; Öner, Yaşar Ali</creator><creatorcontrib>Akgül, Özer ; Demirel, Ömer Faruk ; Aksoy Poyraz, Cana ; Tanriöver Aydin, Ezgi ; Uysal, Nuray ; Bulu, Ersel ; Sapmaz, Burcu ; Çalişkan, Reyhan ; Öner, Yaşar Ali</creatorcontrib><description>Introduction
The opinion that latent Toxoplasma gondii infection is having a broadly asymptomatic projection has now been interrogated, in specific due to the echoed association between the latent infection and an elevated incidence of schizophrenia or even suicide attempts. Notwithstanding conducted studies aimed to understand this feasible link are restricted.
Methods
In the present case‐control study, we focused to illuminate the relationship between the serological and molecular presence of T gondii and schizophrenia with or without the suicide attempts by comparing it with healthy individuals. A total of 237 participants (117 in schizophrenia and 120 in healthy control) were included in this study.
Results
Overall, latent T gondii infections were found statistically higher in 63 (53.8%) of the 117 patients with schizophrenia and in 33 (27.5%) of the 120 controls (P < .001). In schizophrenia patients, seroprevalence T gondii was again found to be statistically higher in suicide attempters (59.6%), compared with no history of suicide attempts (48.3%; P < .05). The molecular positivity rate of T gondii DNA was higher in the schizophrenia group, compared with the healthy control group (P < .05), whereas the history of suicide attempts was not statistically associated (P = .831) with T gondii DNA positivity by polymerase chain reaction.
Conclusion
This case‐control study enlightens additional demonstration to the belief that T gondii infection would be an underlying component for the pathophysiology of schizophrenia. Regardless of the clarity results of this study, this supposition warrants further endorsement.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.14449</identifier><language>eng</language><publisher>London: Hindawi Limited</publisher><subject>Deoxyribonucleic acid ; DNA ; Infections ; Latent infection ; Mental disorders ; Polymerase chain reaction ; Schizophrenia ; Serology ; Suicide ; Suicides & suicide attempts ; Toxoplasma gondii</subject><ispartof>International journal of clinical practice (Esher), 2021-08, Vol.75 (8), p.e14449-n/a</ispartof><rights>2021 John Wiley & Sons Ltd</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3709-11684dfa94046dabd457d0f398250f765741660cc4a93d95bda7eef1048153193</citedby><cites>FETCH-LOGICAL-c3709-11684dfa94046dabd457d0f398250f765741660cc4a93d95bda7eef1048153193</cites><orcidid>0000-0002-3802-3270</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.14449$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.14449$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Akgül, Özer</creatorcontrib><creatorcontrib>Demirel, Ömer Faruk</creatorcontrib><creatorcontrib>Aksoy Poyraz, Cana</creatorcontrib><creatorcontrib>Tanriöver Aydin, Ezgi</creatorcontrib><creatorcontrib>Uysal, Nuray</creatorcontrib><creatorcontrib>Bulu, Ersel</creatorcontrib><creatorcontrib>Sapmaz, Burcu</creatorcontrib><creatorcontrib>Çalişkan, Reyhan</creatorcontrib><creatorcontrib>Öner, Yaşar Ali</creatorcontrib><title>Toxoplasma gondii infection by serological and molecular methods in schizophrenia patients with and without suicide attempts: An age‐sex‐matched case‐control study</title><title>International journal of clinical practice (Esher)</title><description>Introduction
The opinion that latent Toxoplasma gondii infection is having a broadly asymptomatic projection has now been interrogated, in specific due to the echoed association between the latent infection and an elevated incidence of schizophrenia or even suicide attempts. Notwithstanding conducted studies aimed to understand this feasible link are restricted.
Methods
In the present case‐control study, we focused to illuminate the relationship between the serological and molecular presence of T gondii and schizophrenia with or without the suicide attempts by comparing it with healthy individuals. A total of 237 participants (117 in schizophrenia and 120 in healthy control) were included in this study.
Results
Overall, latent T gondii infections were found statistically higher in 63 (53.8%) of the 117 patients with schizophrenia and in 33 (27.5%) of the 120 controls (P < .001). In schizophrenia patients, seroprevalence T gondii was again found to be statistically higher in suicide attempters (59.6%), compared with no history of suicide attempts (48.3%; P < .05). The molecular positivity rate of T gondii DNA was higher in the schizophrenia group, compared with the healthy control group (P < .05), whereas the history of suicide attempts was not statistically associated (P = .831) with T gondii DNA positivity by polymerase chain reaction.
Conclusion
This case‐control study enlightens additional demonstration to the belief that T gondii infection would be an underlying component for the pathophysiology of schizophrenia. Regardless of the clarity results of this study, this supposition warrants further endorsement.</description><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Infections</subject><subject>Latent infection</subject><subject>Mental disorders</subject><subject>Polymerase chain reaction</subject><subject>Schizophrenia</subject><subject>Serology</subject><subject>Suicide</subject><subject>Suicides & suicide attempts</subject><subject>Toxoplasma gondii</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp90c1u1DAQB_AIUYnScuEJLHFBSCl2bOeDW7UqUFSpHMo58tqTjVeOHTyO2uXEI_AavBZPgtPlxKE-2CPrN2NL_6J4zegFy-u93ev5ggkhumfFKWtEVbJKsOe55nVbSsrZi-Il4p7SSsqWnha_78JDmJ3CSZFd8MZaYv0AOtngyfZAEGJwYWe1ckR5Q6bgQC9ORTJBGoPBzAnq0f4I8xjBW0VmlSz4hOTepvGxaS3CkgguVlsDRKUE05zwA7n0RO3gz89fCA95n1TSIxiiFa6XOviUnyeYFnM4L04G5RBe_TvPim8fr-42n8ub20_Xm8ubUvOGdiVjdSvMoDpBRW3U1gjZGDrwrq0kHZpaNoLVNdVaqI6bTm6NagAGRkXLJGcdPyveHufOMXxfAFM_WdTgnPIQFuwryTtZyYrxTN_8R_dhiT7_LivJhairblXvjkrHgBhh6OdoJxUPPaP9mlq_ptY_ppYxO-J76-DwhOyvv2y-Hnv-AtZEoEM</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Akgül, Özer</creator><creator>Demirel, Ömer Faruk</creator><creator>Aksoy Poyraz, Cana</creator><creator>Tanriöver Aydin, Ezgi</creator><creator>Uysal, Nuray</creator><creator>Bulu, Ersel</creator><creator>Sapmaz, Burcu</creator><creator>Çalişkan, Reyhan</creator><creator>Öner, Yaşar Ali</creator><general>Hindawi Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3802-3270</orcidid></search><sort><creationdate>202108</creationdate><title>Toxoplasma gondii infection by serological and molecular methods in schizophrenia patients with and without suicide attempts: An age‐sex‐matched case‐control study</title><author>Akgül, Özer ; Demirel, Ömer Faruk ; Aksoy Poyraz, Cana ; Tanriöver Aydin, Ezgi ; Uysal, Nuray ; Bulu, Ersel ; Sapmaz, Burcu ; Çalişkan, Reyhan ; Öner, Yaşar Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3709-11684dfa94046dabd457d0f398250f765741660cc4a93d95bda7eef1048153193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Infections</topic><topic>Latent infection</topic><topic>Mental disorders</topic><topic>Polymerase chain reaction</topic><topic>Schizophrenia</topic><topic>Serology</topic><topic>Suicide</topic><topic>Suicides & suicide attempts</topic><topic>Toxoplasma gondii</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akgül, Özer</creatorcontrib><creatorcontrib>Demirel, Ömer Faruk</creatorcontrib><creatorcontrib>Aksoy Poyraz, Cana</creatorcontrib><creatorcontrib>Tanriöver Aydin, Ezgi</creatorcontrib><creatorcontrib>Uysal, Nuray</creatorcontrib><creatorcontrib>Bulu, Ersel</creatorcontrib><creatorcontrib>Sapmaz, Burcu</creatorcontrib><creatorcontrib>Çalişkan, Reyhan</creatorcontrib><creatorcontrib>Öner, Yaşar Ali</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akgül, Özer</au><au>Demirel, Ömer Faruk</au><au>Aksoy Poyraz, Cana</au><au>Tanriöver Aydin, Ezgi</au><au>Uysal, Nuray</au><au>Bulu, Ersel</au><au>Sapmaz, Burcu</au><au>Çalişkan, Reyhan</au><au>Öner, Yaşar Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxoplasma gondii infection by serological and molecular methods in schizophrenia patients with and without suicide attempts: An age‐sex‐matched case‐control study</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><date>2021-08</date><risdate>2021</risdate><volume>75</volume><issue>8</issue><spage>e14449</spage><epage>n/a</epage><pages>e14449-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Introduction
The opinion that latent Toxoplasma gondii infection is having a broadly asymptomatic projection has now been interrogated, in specific due to the echoed association between the latent infection and an elevated incidence of schizophrenia or even suicide attempts. Notwithstanding conducted studies aimed to understand this feasible link are restricted.
Methods
In the present case‐control study, we focused to illuminate the relationship between the serological and molecular presence of T gondii and schizophrenia with or without the suicide attempts by comparing it with healthy individuals. A total of 237 participants (117 in schizophrenia and 120 in healthy control) were included in this study.
Results
Overall, latent T gondii infections were found statistically higher in 63 (53.8%) of the 117 patients with schizophrenia and in 33 (27.5%) of the 120 controls (P < .001). In schizophrenia patients, seroprevalence T gondii was again found to be statistically higher in suicide attempters (59.6%), compared with no history of suicide attempts (48.3%; P < .05). The molecular positivity rate of T gondii DNA was higher in the schizophrenia group, compared with the healthy control group (P < .05), whereas the history of suicide attempts was not statistically associated (P = .831) with T gondii DNA positivity by polymerase chain reaction.
Conclusion
This case‐control study enlightens additional demonstration to the belief that T gondii infection would be an underlying component for the pathophysiology of schizophrenia. Regardless of the clarity results of this study, this supposition warrants further endorsement.</abstract><cop>London</cop><pub>Hindawi Limited</pub><doi>10.1111/ijcp.14449</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-3802-3270</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1368-5031 |
| ispartof | International journal of clinical practice (Esher), 2021-08, Vol.75 (8), p.e14449-n/a |
| issn | 1368-5031 1742-1241 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2539525213 |
| source | Access via Wiley Online Library |
| subjects | Deoxyribonucleic acid DNA Infections Latent infection Mental disorders Polymerase chain reaction Schizophrenia Serology Suicide Suicides & suicide attempts Toxoplasma gondii |
| title | Toxoplasma gondii infection by serological and molecular methods in schizophrenia patients with and without suicide attempts: An age‐sex‐matched case‐control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T20%3A38%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Toxoplasma%20gondii%20infection%20by%20serological%20and%20molecular%20methods%20in%20schizophrenia%20patients%20with%20and%20without%20suicide%20attempts:%20An%20age%E2%80%90sex%E2%80%90matched%20case%E2%80%90control%20study&rft.jtitle=International%20journal%20of%20clinical%20practice%20(Esher)&rft.au=Akg%C3%BCl,%20%C3%96zer&rft.date=2021-08&rft.volume=75&rft.issue=8&rft.spage=e14449&rft.epage=n/a&rft.pages=e14449-n/a&rft.issn=1368-5031&rft.eissn=1742-1241&rft_id=info:doi/10.1111/ijcp.14449&rft_dat=%3Cproquest_cross%3E2539525213%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2553446293&rft_id=info:pmid/&rfr_iscdi=true |