Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating lymphocytes (TILs) respond to lipids within the TME. We found elevated concentrations of several classes of lipids in t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-07, Vol.54 (7), p.1561-1577.e7
Hauptverfasser:	Xu, Shihao, Chaudhary, Omkar, Rodríguez-Morales, Patricia, Sun, Xiaoli, Chen, Dan, Zappasodi, Roberta, Xu, Ziyan, Pinto, Antonio F.M., Williams, April, Schulze, Isabell, Farsakoglu, Yagmur, Varanasi, Siva Karthik, Low, Jun Siong, Tang, Wenxi, Wang, Haiping, McDonald, Bryan, Tripple, Victoria, Downes, Michael, Evans, Ronald M., Abumrad, Nada A., Merghoub, Taha, Wolchok, Jedd D., Shokhirev, Maxim N., Ho, Ping-Chih, Witztum, Joseph L., Emu, Brinda, Cui, Guoliang, Kaech, Susan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animals Antigens Atherosclerosis Biological Transport - physiology Cancer CD36 CD36 antigen CD36 Antigens - metabolism CD8 antigen CD8+ T cells CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cholesterol Cytokines Effector cells Fatty acids Flow cytometry Gene expression Glutathione Glutathione peroxidase HEK293 Cells Homeostasis Humans Immunotherapy Kinases Leukocytes, Mononuclear - metabolism Lipid peroxidation Lipid Peroxidation - physiology Lipids Lipoproteins Lipoproteins, LDL - metabolism Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - metabolism Metabolism Mice Mice, Inbred C57BL Mice, Transgenic Neoplasms - metabolism oxidized lipids Peroxidase Peroxidation Receptors Receptors, Scavenger - metabolism Scavenger receptors Tumor microenvironment Tumor Microenvironment - physiology Tumor necrosis factor-TNF Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!