The Course of Disease in Major Depressive Disorder Is Associated With Altered Activity of the Limbic System During Negative Emotion Processing
Brain functional alterations during emotion processing in patients with major depressive disorder (MDD) compared with healthy control subjects (HCs) are frequently reported. However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. This study invest...
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| Veröffentlicht in: | Biological psychiatry : cognitive neuroscience and neuroimaging 2022-03, Vol.7 (3), p.323-332 |
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| creator | Lemke, Hannah Probst, Stefanie Warneke, Antonia Waltemate, Lena Winter, Alexandra Thiel, Katharina Meinert, Susanne Enneking, Verena Breuer, Fabian Klug, Melissa Goltermann, Janik Hülsmann, Carina Grotegerd, Dominik Redlich, Ronny Dohm, Katharina Leehr, Elisabeth J. Repple, Jonathan Opel, Nils Brosch, Katharina Meller, Tina Pfarr, Julia-Katharina Ringwald, Kai Schmitt, Simon Stein, Frederike Krug, Axel Jansen, Andreas Nenadic, Igor Kircher, Tilo Hahn, Tim Dannlowski, Udo |
| description | Brain functional alterations during emotion processing in patients with major depressive disorder (MDD) compared with healthy control subjects (HCs) are frequently reported. However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. This study investigates the role of lifetime disease course for limbic brain activation during negative emotional face processing in patients with MDD.
In a large sample of patients with MDD (n = 333; 58.55% female) and HCs (n = 333; 60.06% female), brain activation was investigated during a negative emotional face-processing task within a cross-sectional design. Differences between HC and MDD groups were analyzed. Previous disease course, characterized by 2 components, namely hospitalization and duration of illness, was regressed on brain activation of the amygdala, (para-)hippocampus, and insula in patients with MDD.
Patients with MDD showed increased activation in the amygdala, insula, and hippocampus compared with HCs (all p values corrected for familywise error [pFWE] < .045). The hospitalization component showed negative associations with brain activation in the bilateral insula (right: pFWE = .026, left: pFWE = .019) and (para-)hippocampus (right: pFWE = .038, left: pFWE = .031). No significant association was found for the duration of illness component (all pFWE > .057).
This study investigated negative emotion processing in a large sample of patients with MDD and HCs. Our results confirm limbic hyperactivation in patients with MDD during negative emotion processing; however, this hyperactivation may resolve with a more severe lifetime disease course in the insula and (para-)hippocampus—brain regions involved in emotion processing and regulation. These findings need further replication in longitudinal studies. |
| doi_str_mv | 10.1016/j.bpsc.2021.05.008 |
| format | Article |
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In a large sample of patients with MDD (n = 333; 58.55% female) and HCs (n = 333; 60.06% female), brain activation was investigated during a negative emotional face-processing task within a cross-sectional design. Differences between HC and MDD groups were analyzed. Previous disease course, characterized by 2 components, namely hospitalization and duration of illness, was regressed on brain activation of the amygdala, (para-)hippocampus, and insula in patients with MDD.
Patients with MDD showed increased activation in the amygdala, insula, and hippocampus compared with HCs (all p values corrected for familywise error [pFWE] < .045). The hospitalization component showed negative associations with brain activation in the bilateral insula (right: pFWE = .026, left: pFWE = .019) and (para-)hippocampus (right: pFWE = .038, left: pFWE = .031). No significant association was found for the duration of illness component (all pFWE > .057).
This study investigated negative emotion processing in a large sample of patients with MDD and HCs. Our results confirm limbic hyperactivation in patients with MDD during negative emotion processing; however, this hyperactivation may resolve with a more severe lifetime disease course in the insula and (para-)hippocampus—brain regions involved in emotion processing and regulation. These findings need further replication in longitudinal studies.</description><identifier>ISSN: 2451-9022</identifier><identifier>EISSN: 2451-9030</identifier><identifier>DOI: 10.1016/j.bpsc.2021.05.008</identifier><identifier>PMID: 34102346</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>(Para-)hippocampus ; Amygdala ; Cross-Sectional Studies ; Depression ; Depressive Disorder, Major ; Disease course ; Emotions - physiology ; Female ; Functional magnetic resonance imaging ; Humans ; Insula ; Limbic System ; Magnetic Resonance Imaging ; Male</subject><ispartof>Biological psychiatry : cognitive neuroscience and neuroimaging, 2022-03, Vol.7 (3), p.323-332</ispartof><rights>2021 Society of Biological Psychiatry</rights><rights>Copyright © 2021 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8a9cb7bdeab2c605c8e8e3bc7da3063f92764caf07b77307e9e6dbf0d7e5cf963</citedby><cites>FETCH-LOGICAL-c356t-8a9cb7bdeab2c605c8e8e3bc7da3063f92764caf07b77307e9e6dbf0d7e5cf963</cites><orcidid>0000-0002-0623-3759</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34102346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemke, Hannah</creatorcontrib><creatorcontrib>Probst, Stefanie</creatorcontrib><creatorcontrib>Warneke, Antonia</creatorcontrib><creatorcontrib>Waltemate, Lena</creatorcontrib><creatorcontrib>Winter, Alexandra</creatorcontrib><creatorcontrib>Thiel, Katharina</creatorcontrib><creatorcontrib>Meinert, Susanne</creatorcontrib><creatorcontrib>Enneking, Verena</creatorcontrib><creatorcontrib>Breuer, Fabian</creatorcontrib><creatorcontrib>Klug, Melissa</creatorcontrib><creatorcontrib>Goltermann, Janik</creatorcontrib><creatorcontrib>Hülsmann, Carina</creatorcontrib><creatorcontrib>Grotegerd, Dominik</creatorcontrib><creatorcontrib>Redlich, Ronny</creatorcontrib><creatorcontrib>Dohm, Katharina</creatorcontrib><creatorcontrib>Leehr, Elisabeth J.</creatorcontrib><creatorcontrib>Repple, Jonathan</creatorcontrib><creatorcontrib>Opel, Nils</creatorcontrib><creatorcontrib>Brosch, Katharina</creatorcontrib><creatorcontrib>Meller, Tina</creatorcontrib><creatorcontrib>Pfarr, Julia-Katharina</creatorcontrib><creatorcontrib>Ringwald, Kai</creatorcontrib><creatorcontrib>Schmitt, Simon</creatorcontrib><creatorcontrib>Stein, Frederike</creatorcontrib><creatorcontrib>Krug, Axel</creatorcontrib><creatorcontrib>Jansen, Andreas</creatorcontrib><creatorcontrib>Nenadic, Igor</creatorcontrib><creatorcontrib>Kircher, Tilo</creatorcontrib><creatorcontrib>Hahn, Tim</creatorcontrib><creatorcontrib>Dannlowski, Udo</creatorcontrib><title>The Course of Disease in Major Depressive Disorder Is Associated With Altered Activity of the Limbic System During Negative Emotion Processing</title><title>Biological psychiatry : cognitive neuroscience and neuroimaging</title><addtitle>Biol Psychiatry Cogn Neurosci Neuroimaging</addtitle><description>Brain functional alterations during emotion processing in patients with major depressive disorder (MDD) compared with healthy control subjects (HCs) are frequently reported. However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. This study investigates the role of lifetime disease course for limbic brain activation during negative emotional face processing in patients with MDD.
In a large sample of patients with MDD (n = 333; 58.55% female) and HCs (n = 333; 60.06% female), brain activation was investigated during a negative emotional face-processing task within a cross-sectional design. Differences between HC and MDD groups were analyzed. Previous disease course, characterized by 2 components, namely hospitalization and duration of illness, was regressed on brain activation of the amygdala, (para-)hippocampus, and insula in patients with MDD.
Patients with MDD showed increased activation in the amygdala, insula, and hippocampus compared with HCs (all p values corrected for familywise error [pFWE] < .045). The hospitalization component showed negative associations with brain activation in the bilateral insula (right: pFWE = .026, left: pFWE = .019) and (para-)hippocampus (right: pFWE = .038, left: pFWE = .031). No significant association was found for the duration of illness component (all pFWE > .057).
This study investigated negative emotion processing in a large sample of patients with MDD and HCs. Our results confirm limbic hyperactivation in patients with MDD during negative emotion processing; however, this hyperactivation may resolve with a more severe lifetime disease course in the insula and (para-)hippocampus—brain regions involved in emotion processing and regulation. These findings need further replication in longitudinal studies.</description><subject>(Para-)hippocampus</subject><subject>Amygdala</subject><subject>Cross-Sectional Studies</subject><subject>Depression</subject><subject>Depressive Disorder, Major</subject><subject>Disease course</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Insula</subject><subject>Limbic System</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><issn>2451-9022</issn><issn>2451-9030</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rGzEQhpfS0oQ0f6CHomMv3owk764XejF20gTcD2hKj0Ifs46Md-VqtAb_if7manGaY9FBI-Z9n0HzFsV7DiUHXt_sSnMgWwoQvISqBFi8Ki7FvOKzFiS8fqmFuCiuiXYA2QUgW_62uJBzDkLO68viz-MTslUYIyELHVt7Qp1LP7AvehciW-MhIpE_4tQL0WFkD8SWRMF6ndCxXz49seU-YcyPpU3-6NNpYqVM3vjeeMt-nChhz9Zj9MOWfcWtThPxtg_Jh4F9j8FOQ4btu-JNp_eE18_3VfHz7vZxdT_bfPv8sFpuZlZWdZotdGtNYxxqI2wNlV3gAqWxjdMSatm1oqnnVnfQmKaR0GCLtTMduAYr27W1vCo-nrmHGH6PSEn1nizu93rAMJISlWwrwfPJUnGW2hiIInbqEH2v40lxUFMUaqemKNQUhYJK5Siy6cMzfzQ9uhfLv8VnwaezAPMvjx6jIutxsOh8RJuUC_5__L8iyJwy</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Lemke, Hannah</creator><creator>Probst, Stefanie</creator><creator>Warneke, Antonia</creator><creator>Waltemate, Lena</creator><creator>Winter, Alexandra</creator><creator>Thiel, Katharina</creator><creator>Meinert, Susanne</creator><creator>Enneking, Verena</creator><creator>Breuer, Fabian</creator><creator>Klug, Melissa</creator><creator>Goltermann, Janik</creator><creator>Hülsmann, Carina</creator><creator>Grotegerd, Dominik</creator><creator>Redlich, Ronny</creator><creator>Dohm, Katharina</creator><creator>Leehr, Elisabeth J.</creator><creator>Repple, Jonathan</creator><creator>Opel, Nils</creator><creator>Brosch, Katharina</creator><creator>Meller, Tina</creator><creator>Pfarr, Julia-Katharina</creator><creator>Ringwald, Kai</creator><creator>Schmitt, Simon</creator><creator>Stein, Frederike</creator><creator>Krug, Axel</creator><creator>Jansen, Andreas</creator><creator>Nenadic, Igor</creator><creator>Kircher, Tilo</creator><creator>Hahn, Tim</creator><creator>Dannlowski, Udo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0623-3759</orcidid></search><sort><creationdate>20220301</creationdate><title>The Course of Disease in Major Depressive Disorder Is Associated With Altered Activity of the Limbic System During Negative Emotion Processing</title><author>Lemke, Hannah ; 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However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. This study investigates the role of lifetime disease course for limbic brain activation during negative emotional face processing in patients with MDD.
In a large sample of patients with MDD (n = 333; 58.55% female) and HCs (n = 333; 60.06% female), brain activation was investigated during a negative emotional face-processing task within a cross-sectional design. Differences between HC and MDD groups were analyzed. Previous disease course, characterized by 2 components, namely hospitalization and duration of illness, was regressed on brain activation of the amygdala, (para-)hippocampus, and insula in patients with MDD.
Patients with MDD showed increased activation in the amygdala, insula, and hippocampus compared with HCs (all p values corrected for familywise error [pFWE] < .045). The hospitalization component showed negative associations with brain activation in the bilateral insula (right: pFWE = .026, left: pFWE = .019) and (para-)hippocampus (right: pFWE = .038, left: pFWE = .031). No significant association was found for the duration of illness component (all pFWE > .057).
This study investigated negative emotion processing in a large sample of patients with MDD and HCs. Our results confirm limbic hyperactivation in patients with MDD during negative emotion processing; however, this hyperactivation may resolve with a more severe lifetime disease course in the insula and (para-)hippocampus—brain regions involved in emotion processing and regulation. These findings need further replication in longitudinal studies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34102346</pmid><doi>10.1016/j.bpsc.2021.05.008</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0623-3759</orcidid></addata></record> |
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| ispartof | Biological psychiatry : cognitive neuroscience and neuroimaging, 2022-03, Vol.7 (3), p.323-332 |
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| language | eng |
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| subjects | (Para-)hippocampus Amygdala Cross-Sectional Studies Depression Depressive Disorder, Major Disease course Emotions - physiology Female Functional magnetic resonance imaging Humans Insula Limbic System Magnetic Resonance Imaging Male |
| title | The Course of Disease in Major Depressive Disorder Is Associated With Altered Activity of the Limbic System During Negative Emotion Processing |
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