The role of T cells in age-related diseases
Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focus...
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| Veröffentlicht in: | Nature reviews. Immunology 2022-02, Vol.22 (2), p.97-111 |
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| container_title | Nature reviews. Immunology |
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| creator | Carrasco, Elisa Gómez de las Heras, Manuel M. Gabandé-Rodríguez, Enrique Desdín-Micó, Gabriela Aranda, Juan Francisco Mittelbrunn, Maria |
| description | Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that ‘resetting’ immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.
In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases. |
| doi_str_mv | 10.1038/s41577-021-00557-4 |
| format | Article |
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In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases.</description><identifier>ISSN: 1474-1733</identifier><identifier>EISSN: 1474-1741</identifier><identifier>DOI: 10.1038/s41577-021-00557-4</identifier><identifier>PMID: 34099898</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/1619/554 ; 692/699 ; Age ; Aging ; Biomedical and Life Sciences ; Biomedicine ; Cytokines ; Cytotoxicity ; Gastrointestinal Microbiome - physiology ; Humans ; Immune clearance ; Immune system ; Immune Tolerance ; Immunological tolerance ; Immunology ; Inflammation ; Intestinal microflora ; Lymphocytes ; Lymphocytes T ; Microbiota ; Neuromodulation ; Regeneration ; Review Article ; T-Lymphocytes ; Tissue engineering</subject><ispartof>Nature reviews. Immunology, 2022-02, Vol.22 (2), p.97-111</ispartof><rights>Springer Nature Limited 2021</rights><rights>2021. Springer Nature Limited.</rights><rights>Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5437fd2d05308b48aa33e2bd16c0a7a9df1034b4f97ed3b5eb1fc644a64445c53</citedby><cites>FETCH-LOGICAL-c375t-5437fd2d05308b48aa33e2bd16c0a7a9df1034b4f97ed3b5eb1fc644a64445c53</cites><orcidid>0000-0003-3487-8762 ; 0000-0002-0817-1627 ; 0000-0001-7447-694X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34099898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrasco, Elisa</creatorcontrib><creatorcontrib>Gómez de las Heras, Manuel M.</creatorcontrib><creatorcontrib>Gabandé-Rodríguez, Enrique</creatorcontrib><creatorcontrib>Desdín-Micó, Gabriela</creatorcontrib><creatorcontrib>Aranda, Juan Francisco</creatorcontrib><creatorcontrib>Mittelbrunn, Maria</creatorcontrib><title>The role of T cells in age-related diseases</title><title>Nature reviews. Immunology</title><addtitle>Nat Rev Immunol</addtitle><addtitle>Nat Rev Immunol</addtitle><description>Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that ‘resetting’ immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.
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Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrasco, Elisa</au><au>Gómez de las Heras, Manuel M.</au><au>Gabandé-Rodríguez, Enrique</au><au>Desdín-Micó, Gabriela</au><au>Aranda, Juan Francisco</au><au>Mittelbrunn, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of T cells in age-related diseases</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>22</volume><issue>2</issue><spage>97</spage><epage>111</epage><pages>97-111</pages><issn>1474-1733</issn><eissn>1474-1741</eissn><abstract>Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. 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| subjects | 631/250/1619/554 692/699 Age Aging Biomedical and Life Sciences Biomedicine Cytokines Cytotoxicity Gastrointestinal Microbiome - physiology Humans Immune clearance Immune system Immune Tolerance Immunological tolerance Immunology Inflammation Intestinal microflora Lymphocytes Lymphocytes T Microbiota Neuromodulation Regeneration Review Article T-Lymphocytes Tissue engineering |
| title | The role of T cells in age-related diseases |
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