Ligand-centred redox activation of inert organoiridium anticancer catalysts

Organometallic complexes with novel activation mechanisms are attractive anticancer drug candidates. Here, we show that half-sandwich iodido cyclopentadienyl iridium( iii ) azopyridine complexes exhibit potent antiproliferative activity towards cancer cells, in most cases more potent than cisplatin....

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Veröffentlicht in:	Chemical science (Cambridge) 2020-06, Vol.11 (21), p.5466-548
Hauptverfasser:	Zhang, Wen-Ying, Banerjee, Samya, Hughes, George M, Bridgewater, Hannah E, Song, Ji-Inn, Breeze, Ben G, Clarkson, Guy J, Coverdale, James P. C, Sanchez-Cano, Carlos, Ponte, Fortuna, Sicilia, Emilia, Sadler, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Cancer Catalysts Chemical compounds Chemistry Crystallography Drugs Glutathione Hydroxyl radicals Iridium compounds Ligands Oxidation Redox reactions
Online-Zugang:	Volltext
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