Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study
Background Lymphomas in the oral and oropharyngeal regions are relatively uncommon, and their diagnosis is challenging and complex due to the myriad histopathological subtypes. Herein, we report a large series of oral and oropharyngeal lymphomas and compare our data with the currently available lite...
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| Veröffentlicht in: | Journal of oral pathology & medicine 2021-07, Vol.50 (6), p.603-612 |
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| creator | de Arruda, José Alcides Almeida Schuch, Lauren Frenzel Conte Neto, Nicolau de Souza, Lucas Lacerda Rodrigues‐Fernandes, Carla Isabelly Abreu, Lucas Guimarães Soares, Ciro Dantas de Carvalho, Maria Goretti Freire Agostini, Michelle de Andrade, Bruno Augusto Benevenuto Romañach, Mário José Zanella, Virgilio Gonzales Barra, Marinez Bizarro Martins, Manoela Domingues Souto, Giovanna Ribeiro Etges, Adriana Pontes, Hélder Antônio Rebelo Pontes, Flávia Sirotheau Correa Vargas, Pablo Agustin de Almeida, Oslei Paes Santos‐Silva, Alan Roger Lopes, Marcio Ajudarte Pires, Fábio Ramôa Gomez, Ricardo Santiago Fonseca, Felipe Paiva Mesquita, Ricardo Alves |
| description | Background
Lymphomas in the oral and oropharyngeal regions are relatively uncommon, and their diagnosis is challenging and complex due to the myriad histopathological subtypes. Herein, we report a large series of oral and oropharyngeal lymphomas and compare our data with the currently available literature.
Methods
All cases diagnosed as lymphomas affecting the oral and oropharyngeal regions were retrospectively retrieved from seven Brazilian institutions. Clinicodemographic data and histopathological features were evaluated and described, while a comprehensive literature review was undertaken in order to compare our findings.
Results
A total of 304 cases of oral and oropharyngeal lymphomas were obtained, mostly affecting individuals aged 60–69 years (n = 68) with a mean age at diagnosis of 54.2 ± 20.1 years. Males and females were equally affected. Mature B‐cell neoplasms (87.2%) were the most common group, followed by mature T‐ and NK‐cell neoplasms (11.2%) and precursor lymphoid neoplasms (1.6%). The most frequent subtypes in each group were diffuse large B‐cell lymphomas, not otherwise specified (n = 99), extranodal NK/T‐cell lymphomas, nasal type (n = 12), and B‐lymphoblastic leukaemia/lymphomas, not otherwise specified (n = 4). The most commonly involved sites were the palate (26.3%), mandible (13%), and maxilla (10.5%).
Conclusion
Diffuse large B‐cell lymphoma, not otherwise specified, remains the most common subtype of lymphomas in the oral and oropharyngeal region. Older patients are the most affected, with no gender predilection and the palate and jaw are usually affected. |
| doi_str_mv | 10.1111/jop.13211 |
| format | Article |
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Lymphomas in the oral and oropharyngeal regions are relatively uncommon, and their diagnosis is challenging and complex due to the myriad histopathological subtypes. Herein, we report a large series of oral and oropharyngeal lymphomas and compare our data with the currently available literature.
Methods
All cases diagnosed as lymphomas affecting the oral and oropharyngeal regions were retrospectively retrieved from seven Brazilian institutions. Clinicodemographic data and histopathological features were evaluated and described, while a comprehensive literature review was undertaken in order to compare our findings.
Results
A total of 304 cases of oral and oropharyngeal lymphomas were obtained, mostly affecting individuals aged 60–69 years (n = 68) with a mean age at diagnosis of 54.2 ± 20.1 years. Males and females were equally affected. Mature B‐cell neoplasms (87.2%) were the most common group, followed by mature T‐ and NK‐cell neoplasms (11.2%) and precursor lymphoid neoplasms (1.6%). The most frequent subtypes in each group were diffuse large B‐cell lymphomas, not otherwise specified (n = 99), extranodal NK/T‐cell lymphomas, nasal type (n = 12), and B‐lymphoblastic leukaemia/lymphomas, not otherwise specified (n = 4). The most commonly involved sites were the palate (26.3%), mandible (13%), and maxilla (10.5%).
Conclusion
Diffuse large B‐cell lymphoma, not otherwise specified, remains the most common subtype of lymphomas in the oral and oropharyngeal region. Older patients are the most affected, with no gender predilection and the palate and jaw are usually affected.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.13211</identifier><identifier>PMID: 34091952</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Brazil - epidemiology ; Diagnosis ; diffuse large B‐cell lymphoma ; Female ; Humans ; Jaw ; Literature reviews ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse ; Male ; Mandible ; Maxilla ; non‐hodgkin lymphoma ; oral cavity ; oropharynx ; Palate ; Retrospective Studies ; T cell lymphoma ; Tumors</subject><ispartof>Journal of oral pathology & medicine, 2021-07, Vol.50 (6), p.603-612</ispartof><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-fa2080cf75f2182e2837b77cd8955c9fce8c192f018714556369a442d4e323663</citedby><cites>FETCH-LOGICAL-c3531-fa2080cf75f2182e2837b77cd8955c9fce8c192f018714556369a442d4e323663</cites><orcidid>0000-0002-3259-606X ; 0000-0002-1290-6235 ; 0000-0003-0884-004X ; 0000-0003-2258-8071 ; 0000-0002-9481-7796 ; 0000-0002-7609-8804 ; 0000-0003-4981-0461 ; 0000-0003-3207-4007 ; 0000-0002-0993-936X ; 0000-0001-5152-1277 ; 0000-0001-8662-5965 ; 0000-0003-1840-4911 ; 0000-0002-6599-3950 ; 0000-0002-3648-337X ; 0000-0001-8770-8009 ; 0000-0003-2040-6617 ; 0000-0001-5721-9968 ; 0000-0002-6066-869X ; 0000-0002-7853-5916 ; 0000-0003-0317-8878 ; 0000-0002-1680-3102 ; 0000-0002-6861-6640 ; 0000-0001-6677-0065 ; 0000-0002-6657-4547 ; 0000-0003-2002-8003 ; 0000-0003-3617-8794</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.13211$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.13211$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34091952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Arruda, José Alcides Almeida</creatorcontrib><creatorcontrib>Schuch, Lauren Frenzel</creatorcontrib><creatorcontrib>Conte Neto, Nicolau</creatorcontrib><creatorcontrib>de Souza, Lucas Lacerda</creatorcontrib><creatorcontrib>Rodrigues‐Fernandes, Carla Isabelly</creatorcontrib><creatorcontrib>Abreu, Lucas Guimarães</creatorcontrib><creatorcontrib>Soares, Ciro Dantas</creatorcontrib><creatorcontrib>de Carvalho, Maria Goretti Freire</creatorcontrib><creatorcontrib>Agostini, Michelle</creatorcontrib><creatorcontrib>de Andrade, Bruno Augusto Benevenuto</creatorcontrib><creatorcontrib>Romañach, Mário José</creatorcontrib><creatorcontrib>Zanella, Virgilio Gonzales</creatorcontrib><creatorcontrib>Barra, Marinez Bizarro</creatorcontrib><creatorcontrib>Martins, Manoela Domingues</creatorcontrib><creatorcontrib>Souto, Giovanna Ribeiro</creatorcontrib><creatorcontrib>Etges, Adriana</creatorcontrib><creatorcontrib>Pontes, Hélder Antônio Rebelo</creatorcontrib><creatorcontrib>Pontes, Flávia Sirotheau Correa</creatorcontrib><creatorcontrib>Vargas, Pablo Agustin</creatorcontrib><creatorcontrib>de Almeida, Oslei Paes</creatorcontrib><creatorcontrib>Santos‐Silva, Alan Roger</creatorcontrib><creatorcontrib>Lopes, Marcio Ajudarte</creatorcontrib><creatorcontrib>Pires, Fábio Ramôa</creatorcontrib><creatorcontrib>Gomez, Ricardo Santiago</creatorcontrib><creatorcontrib>Fonseca, Felipe Paiva</creatorcontrib><creatorcontrib>Mesquita, Ricardo Alves</creatorcontrib><title>Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background
Lymphomas in the oral and oropharyngeal regions are relatively uncommon, and their diagnosis is challenging and complex due to the myriad histopathological subtypes. Herein, we report a large series of oral and oropharyngeal lymphomas and compare our data with the currently available literature.
Methods
All cases diagnosed as lymphomas affecting the oral and oropharyngeal regions were retrospectively retrieved from seven Brazilian institutions. Clinicodemographic data and histopathological features were evaluated and described, while a comprehensive literature review was undertaken in order to compare our findings.
Results
A total of 304 cases of oral and oropharyngeal lymphomas were obtained, mostly affecting individuals aged 60–69 years (n = 68) with a mean age at diagnosis of 54.2 ± 20.1 years. Males and females were equally affected. Mature B‐cell neoplasms (87.2%) were the most common group, followed by mature T‐ and NK‐cell neoplasms (11.2%) and precursor lymphoid neoplasms (1.6%). The most frequent subtypes in each group were diffuse large B‐cell lymphomas, not otherwise specified (n = 99), extranodal NK/T‐cell lymphomas, nasal type (n = 12), and B‐lymphoblastic leukaemia/lymphomas, not otherwise specified (n = 4). The most commonly involved sites were the palate (26.3%), mandible (13%), and maxilla (10.5%).
Conclusion
Diffuse large B‐cell lymphoma, not otherwise specified, remains the most common subtype of lymphomas in the oral and oropharyngeal region. Older patients are the most affected, with no gender predilection and the palate and jaw are usually affected.</description><subject>Brazil - epidemiology</subject><subject>Diagnosis</subject><subject>diffuse large B‐cell lymphoma</subject><subject>Female</subject><subject>Humans</subject><subject>Jaw</subject><subject>Literature reviews</subject><subject>Lymphoma</subject><subject>Lymphoma, Large B-Cell, Diffuse</subject><subject>Male</subject><subject>Mandible</subject><subject>Maxilla</subject><subject>non‐hodgkin lymphoma</subject><subject>oral cavity</subject><subject>oropharynx</subject><subject>Palate</subject><subject>Retrospective Studies</subject><subject>T cell 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Guimarães</creator><creator>Soares, Ciro Dantas</creator><creator>de Carvalho, Maria Goretti Freire</creator><creator>Agostini, Michelle</creator><creator>de Andrade, Bruno Augusto Benevenuto</creator><creator>Romañach, Mário José</creator><creator>Zanella, Virgilio Gonzales</creator><creator>Barra, Marinez Bizarro</creator><creator>Martins, Manoela Domingues</creator><creator>Souto, Giovanna Ribeiro</creator><creator>Etges, Adriana</creator><creator>Pontes, Hélder Antônio Rebelo</creator><creator>Pontes, Flávia Sirotheau Correa</creator><creator>Vargas, Pablo Agustin</creator><creator>de Almeida, Oslei Paes</creator><creator>Santos‐Silva, Alan Roger</creator><creator>Lopes, Marcio Ajudarte</creator><creator>Pires, Fábio Ramôa</creator><creator>Gomez, Ricardo Santiago</creator><creator>Fonseca, Felipe Paiva</creator><creator>Mesquita, Ricardo Alves</creator><general>Wiley Subscription Services, 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and oropharyngeal lymphomas: A multi‐institutional collaborative study</title><author>de Arruda, José Alcides Almeida ; Schuch, Lauren Frenzel ; Conte Neto, Nicolau ; de Souza, Lucas Lacerda ; Rodrigues‐Fernandes, Carla Isabelly ; Abreu, Lucas Guimarães ; Soares, Ciro Dantas ; de Carvalho, Maria Goretti Freire ; Agostini, Michelle ; de Andrade, Bruno Augusto Benevenuto ; Romañach, Mário José ; Zanella, Virgilio Gonzales ; Barra, Marinez Bizarro ; Martins, Manoela Domingues ; Souto, Giovanna Ribeiro ; Etges, Adriana ; Pontes, Hélder Antônio Rebelo ; Pontes, Flávia Sirotheau Correa ; Vargas, Pablo Agustin ; de Almeida, Oslei Paes ; Santos‐Silva, Alan Roger ; Lopes, Marcio Ajudarte ; Pires, Fábio Ramôa ; Gomez, Ricardo Santiago ; Fonseca, Felipe Paiva ; Mesquita, Ricardo Alves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-fa2080cf75f2182e2837b77cd8955c9fce8c192f018714556369a442d4e323663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brazil - epidemiology</topic><topic>Diagnosis</topic><topic>diffuse large B‐cell lymphoma</topic><topic>Female</topic><topic>Humans</topic><topic>Jaw</topic><topic>Literature reviews</topic><topic>Lymphoma</topic><topic>Lymphoma, Large B-Cell, Diffuse</topic><topic>Male</topic><topic>Mandible</topic><topic>Maxilla</topic><topic>non‐hodgkin lymphoma</topic><topic>oral cavity</topic><topic>oropharynx</topic><topic>Palate</topic><topic>Retrospective Studies</topic><topic>T cell lymphoma</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Arruda, José Alcides Almeida</creatorcontrib><creatorcontrib>Schuch, Lauren Frenzel</creatorcontrib><creatorcontrib>Conte Neto, Nicolau</creatorcontrib><creatorcontrib>de Souza, Lucas Lacerda</creatorcontrib><creatorcontrib>Rodrigues‐Fernandes, Carla Isabelly</creatorcontrib><creatorcontrib>Abreu, Lucas Guimarães</creatorcontrib><creatorcontrib>Soares, Ciro Dantas</creatorcontrib><creatorcontrib>de Carvalho, Maria Goretti Freire</creatorcontrib><creatorcontrib>Agostini, Michelle</creatorcontrib><creatorcontrib>de Andrade, Bruno Augusto Benevenuto</creatorcontrib><creatorcontrib>Romañach, Mário José</creatorcontrib><creatorcontrib>Zanella, Virgilio Gonzales</creatorcontrib><creatorcontrib>Barra, Marinez Bizarro</creatorcontrib><creatorcontrib>Martins, Manoela Domingues</creatorcontrib><creatorcontrib>Souto, Giovanna Ribeiro</creatorcontrib><creatorcontrib>Etges, Adriana</creatorcontrib><creatorcontrib>Pontes, Hélder Antônio Rebelo</creatorcontrib><creatorcontrib>Pontes, Flávia Sirotheau Correa</creatorcontrib><creatorcontrib>Vargas, Pablo Agustin</creatorcontrib><creatorcontrib>de Almeida, Oslei Paes</creatorcontrib><creatorcontrib>Santos‐Silva, Alan Roger</creatorcontrib><creatorcontrib>Lopes, Marcio Ajudarte</creatorcontrib><creatorcontrib>Pires, Fábio Ramôa</creatorcontrib><creatorcontrib>Gomez, Ricardo Santiago</creatorcontrib><creatorcontrib>Fonseca, Felipe Paiva</creatorcontrib><creatorcontrib>Mesquita, Ricardo Alves</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Arruda, José Alcides Almeida</au><au>Schuch, Lauren Frenzel</au><au>Conte Neto, Nicolau</au><au>de Souza, Lucas Lacerda</au><au>Rodrigues‐Fernandes, Carla Isabelly</au><au>Abreu, Lucas Guimarães</au><au>Soares, Ciro Dantas</au><au>de Carvalho, Maria Goretti Freire</au><au>Agostini, Michelle</au><au>de Andrade, Bruno Augusto Benevenuto</au><au>Romañach, Mário José</au><au>Zanella, Virgilio Gonzales</au><au>Barra, Marinez Bizarro</au><au>Martins, Manoela Domingues</au><au>Souto, Giovanna Ribeiro</au><au>Etges, Adriana</au><au>Pontes, Hélder Antônio Rebelo</au><au>Pontes, Flávia Sirotheau Correa</au><au>Vargas, Pablo Agustin</au><au>de Almeida, Oslei Paes</au><au>Santos‐Silva, Alan Roger</au><au>Lopes, Marcio Ajudarte</au><au>Pires, Fábio Ramôa</au><au>Gomez, Ricardo Santiago</au><au>Fonseca, Felipe Paiva</au><au>Mesquita, Ricardo Alves</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2021-07</date><risdate>2021</risdate><volume>50</volume><issue>6</issue><spage>603</spage><epage>612</epage><pages>603-612</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background
Lymphomas in the oral and oropharyngeal regions are relatively uncommon, and their diagnosis is challenging and complex due to the myriad histopathological subtypes. Herein, we report a large series of oral and oropharyngeal lymphomas and compare our data with the currently available literature.
Methods
All cases diagnosed as lymphomas affecting the oral and oropharyngeal regions were retrospectively retrieved from seven Brazilian institutions. Clinicodemographic data and histopathological features were evaluated and described, while a comprehensive literature review was undertaken in order to compare our findings.
Results
A total of 304 cases of oral and oropharyngeal lymphomas were obtained, mostly affecting individuals aged 60–69 years (n = 68) with a mean age at diagnosis of 54.2 ± 20.1 years. Males and females were equally affected. Mature B‐cell neoplasms (87.2%) were the most common group, followed by mature T‐ and NK‐cell neoplasms (11.2%) and precursor lymphoid neoplasms (1.6%). The most frequent subtypes in each group were diffuse large B‐cell lymphomas, not otherwise specified (n = 99), extranodal NK/T‐cell lymphomas, nasal type (n = 12), and B‐lymphoblastic leukaemia/lymphomas, not otherwise specified (n = 4). The most commonly involved sites were the palate (26.3%), mandible (13%), and maxilla (10.5%).
Conclusion
Diffuse large B‐cell lymphoma, not otherwise specified, remains the most common subtype of lymphomas in the oral and oropharyngeal region. Older patients are the most affected, with no gender predilection and the palate and jaw are usually affected.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34091952</pmid><doi>10.1111/jop.13211</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3259-606X</orcidid><orcidid>https://orcid.org/0000-0002-1290-6235</orcidid><orcidid>https://orcid.org/0000-0003-0884-004X</orcidid><orcidid>https://orcid.org/0000-0003-2258-8071</orcidid><orcidid>https://orcid.org/0000-0002-9481-7796</orcidid><orcidid>https://orcid.org/0000-0002-7609-8804</orcidid><orcidid>https://orcid.org/0000-0003-4981-0461</orcidid><orcidid>https://orcid.org/0000-0003-3207-4007</orcidid><orcidid>https://orcid.org/0000-0002-0993-936X</orcidid><orcidid>https://orcid.org/0000-0001-5152-1277</orcidid><orcidid>https://orcid.org/0000-0001-8662-5965</orcidid><orcidid>https://orcid.org/0000-0003-1840-4911</orcidid><orcidid>https://orcid.org/0000-0002-6599-3950</orcidid><orcidid>https://orcid.org/0000-0002-3648-337X</orcidid><orcidid>https://orcid.org/0000-0001-8770-8009</orcidid><orcidid>https://orcid.org/0000-0003-2040-6617</orcidid><orcidid>https://orcid.org/0000-0001-5721-9968</orcidid><orcidid>https://orcid.org/0000-0002-6066-869X</orcidid><orcidid>https://orcid.org/0000-0002-7853-5916</orcidid><orcidid>https://orcid.org/0000-0003-0317-8878</orcidid><orcidid>https://orcid.org/0000-0002-1680-3102</orcidid><orcidid>https://orcid.org/0000-0002-6861-6640</orcidid><orcidid>https://orcid.org/0000-0001-6677-0065</orcidid><orcidid>https://orcid.org/0000-0002-6657-4547</orcidid><orcidid>https://orcid.org/0000-0003-2002-8003</orcidid><orcidid>https://orcid.org/0000-0003-3617-8794</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0904-2512 |
| ispartof | Journal of oral pathology & medicine, 2021-07, Vol.50 (6), p.603-612 |
| issn | 0904-2512 1600-0714 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2538046180 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Brazil - epidemiology Diagnosis diffuse large B‐cell lymphoma Female Humans Jaw Literature reviews Lymphoma Lymphoma, Large B-Cell, Diffuse Male Mandible Maxilla non‐hodgkin lymphoma oral cavity oropharynx Palate Retrospective Studies T cell lymphoma Tumors |
| title | Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study |
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