AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments
Adenine nucleotides are important signaling molecules that mediate biological functions in many conditions, including cancer. The enzymes CD39 and CD73 produce adenosine in the extracellular milieu that has a very important role in tumor development. This study aimed to evaluate nucleotide hydrolysi...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2021-10, Vol.476 (10), p.3719-3727 |
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| creator | Gheler, Fernanda Valente Cappellari, Angélica Regina Renck, Daiana de Souza, Julia Brandt de Melo, Renan Oliveira Moehlecke, Barbara Zanesco Moriguchi, Carolina Aiko Engroff, Paula Lambert, Ana Paula Franco Rockenbach, Liliana Morrone, Fernanda Bueno |
| description | Adenine nucleotides are important signaling molecules that mediate biological functions in many conditions, including cancer. The enzymes CD39 and CD73 produce adenosine in the extracellular milieu that has a very important role in tumor development. This study aimed to evaluate nucleotide hydrolysis in the plasma blood of breast cancer elderly patients. In this prospective cohort study, we investigated the ectonucleotidases activity in breast cancer elderly patients, at the moment of diagnosis and after treatment. Control group consisted of elderly women without cancer diagnostic. The nucleotide hydrolysis assay was performed by the malachite green method and used ATP, ADP, or AMP as substrates. Paired t test or Wilcoxon rank-sum test was used. Our data showed that breast cancer patients presented high levels of ATP and AMP hydrolyses when compared to control group at the moment of diagnosis. When analyzing the differences between the samples at the time of diagnostic and 6 months after treatment, we observed a significant reduction on CD73 activity after all treatments used: surgery, chemotherapy, radiotherapy, or hormone therapy. The results with APCP, a specific CD73 inhibitor, showed that the AMP hydrolysis was inhibited in all conditions evaluated. We observed a diminished ADPase activity in the patients without metastasis when compared to metastatic breast cancer patients. The results showed that AMP hydrolysis was reduced in the blood plasma of breast cancer elderly patients after different treatments. This study strengthens the potential role of CD73 enzyme as a biomarker for breast cancer treatment response. |
| doi_str_mv | 10.1007/s11010-021-04199-x |
| format | Article |
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The enzymes CD39 and CD73 produce adenosine in the extracellular milieu that has a very important role in tumor development. This study aimed to evaluate nucleotide hydrolysis in the plasma blood of breast cancer elderly patients. In this prospective cohort study, we investigated the ectonucleotidases activity in breast cancer elderly patients, at the moment of diagnosis and after treatment. Control group consisted of elderly women without cancer diagnostic. The nucleotide hydrolysis assay was performed by the malachite green method and used ATP, ADP, or AMP as substrates. Paired t test or Wilcoxon rank-sum test was used. Our data showed that breast cancer patients presented high levels of ATP and AMP hydrolyses when compared to control group at the moment of diagnosis. When analyzing the differences between the samples at the time of diagnostic and 6 months after treatment, we observed a significant reduction on CD73 activity after all treatments used: surgery, chemotherapy, radiotherapy, or hormone therapy. The results with APCP, a specific CD73 inhibitor, showed that the AMP hydrolysis was inhibited in all conditions evaluated. We observed a diminished ADPase activity in the patients without metastasis when compared to metastatic breast cancer patients. The results showed that AMP hydrolysis was reduced in the blood plasma of breast cancer elderly patients after different treatments. This study strengthens the potential role of CD73 enzyme as a biomarker for breast cancer treatment response.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-021-04199-x</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adenine ; Adenosine ; Adenosine diphosphate ; Adenosine triphosphate ; Aged patients ; AMP ; ATP ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Blood ; Blood plasma ; Breast cancer ; Cancer ; Cancer patients ; Cancer therapies ; Cardiology ; Care and treatment ; CD73 antigen ; Chemotherapy ; Development and progression ; Diagnosis ; Diagnostic systems ; Enzymes ; Hydrolysis ; Life Sciences ; Malachite green ; Medical Biochemistry ; Metastases ; Nucleotides ; Older people ; Oncology ; Oncology, Experimental ; Patients ; Radiation therapy ; Rankings ; Substrates</subject><ispartof>Molecular and cellular biochemistry, 2021-10, Vol.476 (10), p.3719-3727</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-cc787dd9329fc0161579f004f968c3a8f8c28d709095be2679d89ba7b428a3c53</citedby><cites>FETCH-LOGICAL-c463t-cc787dd9329fc0161579f004f968c3a8f8c28d709095be2679d89ba7b428a3c53</cites><orcidid>0000-0002-2709-2801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-021-04199-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-021-04199-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Gheler, Fernanda Valente</creatorcontrib><creatorcontrib>Cappellari, Angélica Regina</creatorcontrib><creatorcontrib>Renck, Daiana</creatorcontrib><creatorcontrib>de Souza, Julia Brandt</creatorcontrib><creatorcontrib>de Melo, Renan Oliveira</creatorcontrib><creatorcontrib>Moehlecke, Barbara Zanesco</creatorcontrib><creatorcontrib>Moriguchi, Carolina Aiko</creatorcontrib><creatorcontrib>Engroff, Paula</creatorcontrib><creatorcontrib>Lambert, Ana Paula Franco</creatorcontrib><creatorcontrib>Rockenbach, Liliana</creatorcontrib><creatorcontrib>Morrone, Fernanda Bueno</creatorcontrib><title>AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>Adenine nucleotides are important signaling molecules that mediate biological functions in many conditions, including cancer. The enzymes CD39 and CD73 produce adenosine in the extracellular milieu that has a very important role in tumor development. This study aimed to evaluate nucleotide hydrolysis in the plasma blood of breast cancer elderly patients. In this prospective cohort study, we investigated the ectonucleotidases activity in breast cancer elderly patients, at the moment of diagnosis and after treatment. Control group consisted of elderly women without cancer diagnostic. The nucleotide hydrolysis assay was performed by the malachite green method and used ATP, ADP, or AMP as substrates. Paired t test or Wilcoxon rank-sum test was used. Our data showed that breast cancer patients presented high levels of ATP and AMP hydrolyses when compared to control group at the moment of diagnosis. When analyzing the differences between the samples at the time of diagnostic and 6 months after treatment, we observed a significant reduction on CD73 activity after all treatments used: surgery, chemotherapy, radiotherapy, or hormone therapy. The results with APCP, a specific CD73 inhibitor, showed that the AMP hydrolysis was inhibited in all conditions evaluated. We observed a diminished ADPase activity in the patients without metastasis when compared to metastatic breast cancer patients. The results showed that AMP hydrolysis was reduced in the blood plasma of breast cancer elderly patients after different treatments. This study strengthens the potential role of CD73 enzyme as a biomarker for breast cancer treatment response.</description><subject>Adenine</subject><subject>Adenosine</subject><subject>Adenosine diphosphate</subject><subject>Adenosine triphosphate</subject><subject>Aged patients</subject><subject>AMP</subject><subject>ATP</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Cardiology</subject><subject>Care and treatment</subject><subject>CD73 antigen</subject><subject>Chemotherapy</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Enzymes</subject><subject>Hydrolysis</subject><subject>Life Sciences</subject><subject>Malachite green</subject><subject>Medical Biochemistry</subject><subject>Metastases</subject><subject>Nucleotides</subject><subject>Older people</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Patients</subject><subject>Radiation 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hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments</title><author>Gheler, Fernanda Valente ; Cappellari, Angélica Regina ; Renck, Daiana ; de Souza, Julia Brandt ; de Melo, Renan Oliveira ; Moehlecke, Barbara Zanesco ; Moriguchi, Carolina Aiko ; Engroff, Paula ; Lambert, Ana Paula Franco ; Rockenbach, Liliana ; Morrone, Fernanda Bueno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-cc787dd9329fc0161579f004f968c3a8f8c28d709095be2679d89ba7b428a3c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenine</topic><topic>Adenosine</topic><topic>Adenosine diphosphate</topic><topic>Adenosine triphosphate</topic><topic>Aged patients</topic><topic>AMP</topic><topic>ATP</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Blood</topic><topic>Blood plasma</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Cardiology</topic><topic>Care and treatment</topic><topic>CD73 antigen</topic><topic>Chemotherapy</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Enzymes</topic><topic>Hydrolysis</topic><topic>Life Sciences</topic><topic>Malachite green</topic><topic>Medical Biochemistry</topic><topic>Metastases</topic><topic>Nucleotides</topic><topic>Older people</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>Rankings</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gheler, Fernanda Valente</creatorcontrib><creatorcontrib>Cappellari, Angélica Regina</creatorcontrib><creatorcontrib>Renck, Daiana</creatorcontrib><creatorcontrib>de Souza, Julia Brandt</creatorcontrib><creatorcontrib>de 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biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><date>2021-10-01</date><risdate>2021</risdate><volume>476</volume><issue>10</issue><spage>3719</spage><epage>3727</epage><pages>3719-3727</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Adenine nucleotides are important signaling molecules that mediate biological functions in many conditions, including cancer. The enzymes CD39 and CD73 produce adenosine in the extracellular milieu that has a very important role in tumor development. This study aimed to evaluate nucleotide hydrolysis in the plasma blood of breast cancer elderly patients. In this prospective cohort study, we investigated the ectonucleotidases activity in breast cancer elderly patients, at the moment of diagnosis and after treatment. Control group consisted of elderly women without cancer diagnostic. The nucleotide hydrolysis assay was performed by the malachite green method and used ATP, ADP, or AMP as substrates. Paired t test or Wilcoxon rank-sum test was used. Our data showed that breast cancer patients presented high levels of ATP and AMP hydrolyses when compared to control group at the moment of diagnosis. When analyzing the differences between the samples at the time of diagnostic and 6 months after treatment, we observed a significant reduction on CD73 activity after all treatments used: surgery, chemotherapy, radiotherapy, or hormone therapy. The results with APCP, a specific CD73 inhibitor, showed that the AMP hydrolysis was inhibited in all conditions evaluated. We observed a diminished ADPase activity in the patients without metastasis when compared to metastatic breast cancer patients. The results showed that AMP hydrolysis was reduced in the blood plasma of breast cancer elderly patients after different treatments. This study strengthens the potential role of CD73 enzyme as a biomarker for breast cancer treatment response.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11010-021-04199-x</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2709-2801</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenine Adenosine Adenosine diphosphate Adenosine triphosphate Aged patients AMP ATP Biochemistry Biomarkers Biomedical and Life Sciences Blood Blood plasma Breast cancer Cancer Cancer patients Cancer therapies Cardiology Care and treatment CD73 antigen Chemotherapy Development and progression Diagnosis Diagnostic systems Enzymes Hydrolysis Life Sciences Malachite green Medical Biochemistry Metastases Nucleotides Older people Oncology Oncology, Experimental Patients Radiation therapy Rankings Substrates |
| title | AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments |
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