Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies
Purpose Weight cycling is common in populations. However, it is unclear whether frequency and magnitude of weight cycling is associated with kidney cancer risk, independent of body mass index (BMI). Methods A prospective cohort study followed 85,562 participants from Health Professionals Follow-up S...
Gespeichert in:
| Veröffentlicht in: | Cancer causes & control 2021-09, Vol.32 (9), p.1029-1038 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1038 |
|---|---|
| container_issue | 9 |
| container_start_page | 1029 |
| container_title | Cancer causes & control |
| container_volume | 32 |
| creator | Lee, Dong Hoon Keum, NaNa Rezende, Leandro F. M. Tabung, Fred K. Hong, SungEun Giovannucci, Edward L. |
| description | Purpose
Weight cycling is common in populations. However, it is unclear whether frequency and magnitude of weight cycling is associated with kidney cancer risk, independent of body mass index (BMI).
Methods
A prospective cohort study followed 85,562 participants from Health Professionals Follow-up Study and Nurses’ Health Study (1992–2014). At baseline, participants reported frequency and magnitude of intentional weight loss in the past 4 years. Cox proportional hazard model was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). We also conducted a meta-analysis of all available observational studies including our two cohorts.
Results
During 22 years of follow-up, we identified 441 kidney cancer cases. Compared with non-weight cyclers (no attempt of intentional weight loss), severe cyclers (≥ 3 times of intentional weight loss of ≥ 4.5 kg) were at increased kidney cancer risk after adjusting for BMI before weight cycling (pooled multivariable-adjusted HR, 1.78; 95% CI, 1.19, 2.66). Additional adjustment for attained BMI after weight cycling had minimal influence. There was a positive trend between weight cycling by frequency and magnitude and kidney cancer risk (
P
-trend = 0.01). Moreover, the observed positive association did not differ by subtypes of cyclers (e.g., adiposity status, weight-loss methods). In the meta-analysis, we found a strong positive association between weight cycling and kidney cancer risk (summary relative risk for weight cyclers vs. non-cyclers, 1.51; 95% CI, 1.16, 1.96; I
2
: 52.2%; 6 studies).
Conclusion
Frequent substantial weight cycling was associated with increased risk of kidney cancer, independent of BMI. Our study suggests that weight cycling may be an important risk factor for kidney cancer. |
| doi_str_mv | 10.1007/s10552-021-01455-9 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2537644921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>48757311</jstor_id><sourcerecordid>48757311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-e893d8092e87cac4ade3fe5095592a075db119b819d8e608f27a8ac9ad53a9843</originalsourceid><addsrcrecordid>eNp9kctKAzEUhoMotlZfQFAG3LgZzbVJwE0p3qDgRtchzZyp00umJjOUvr3RqRVcuDqLfP9_Dl8QOif4hmAsbyPBQtAcU5JjwoXI9QHqEyFZLikVh6iPtZC5oJz10EmMc4yxGFJ8jHqMY6W5JH10N4qxdpVtqtpnU2g2AD7bQDV7bzK3dcvKzzLriyxUcZHVZbaoCg_bzFnvIJyio9IuI5zt5gC9Pdy_jp_yycvj83g0yR3TsslBaVYorCko6azjtgBWgkjXCU0tlqKYEqKniuhCwRCrkkqrrNO2EMxqxdkAXXe961B_tBAbs6qig-XSeqjbaKhgcsi5piShV3_Qed0Gn65LlOBDKYiUiaId5UIdY4DSrEO1smFrCDZfbk3n1iS35tut0Sl0uatupyso9pEfmQlgHRDTk59B-N39b-1Fl5rHpg77Vq5k-klC2CdqbIxO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2554675177</pqid></control><display><type>article</type><title>Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lee, Dong Hoon ; Keum, NaNa ; Rezende, Leandro F. M. ; Tabung, Fred K. ; Hong, SungEun ; Giovannucci, Edward L.</creator><creatorcontrib>Lee, Dong Hoon ; Keum, NaNa ; Rezende, Leandro F. M. ; Tabung, Fred K. ; Hong, SungEun ; Giovannucci, Edward L.</creatorcontrib><description>Purpose
Weight cycling is common in populations. However, it is unclear whether frequency and magnitude of weight cycling is associated with kidney cancer risk, independent of body mass index (BMI).
Methods
A prospective cohort study followed 85,562 participants from Health Professionals Follow-up Study and Nurses’ Health Study (1992–2014). At baseline, participants reported frequency and magnitude of intentional weight loss in the past 4 years. Cox proportional hazard model was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). We also conducted a meta-analysis of all available observational studies including our two cohorts.
Results
During 22 years of follow-up, we identified 441 kidney cancer cases. Compared with non-weight cyclers (no attempt of intentional weight loss), severe cyclers (≥ 3 times of intentional weight loss of ≥ 4.5 kg) were at increased kidney cancer risk after adjusting for BMI before weight cycling (pooled multivariable-adjusted HR, 1.78; 95% CI, 1.19, 2.66). Additional adjustment for attained BMI after weight cycling had minimal influence. There was a positive trend between weight cycling by frequency and magnitude and kidney cancer risk (
P
-trend = 0.01). Moreover, the observed positive association did not differ by subtypes of cyclers (e.g., adiposity status, weight-loss methods). In the meta-analysis, we found a strong positive association between weight cycling and kidney cancer risk (summary relative risk for weight cyclers vs. non-cyclers, 1.51; 95% CI, 1.16, 1.96; I
2
: 52.2%; 6 studies).
Conclusion
Frequent substantial weight cycling was associated with increased risk of kidney cancer, independent of BMI. Our study suggests that weight cycling may be an important risk factor for kidney cancer.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-021-01455-9</identifier><identifier>PMID: 34089471</identifier><language>eng</language><publisher>Cham: Springer Science + Business Media</publisher><subject>Adipose tissue ; Biomedical and Life Sciences ; Biomedicine ; Body mass ; Body Mass Index ; Body size ; Body weight loss ; Cancer ; Cancer Research ; Cohort analysis ; Confidence intervals ; Cycles ; Epidemiology ; Follow-Up Studies ; Health risks ; Hematology ; Humans ; Kidney cancer ; Kidney Neoplasms - epidemiology ; Kidney Neoplasms - etiology ; Kidneys ; Medical personnel ; Meta-analysis ; Obesity ; Observational studies ; Observational Studies as Topic ; Oncology ; ORIGINAL PAPER ; Prospective Studies ; Public Health ; Risk analysis ; Risk Factors ; Statistical models ; Weight Gain ; Weight Loss</subject><ispartof>Cancer causes & control, 2021-09, Vol.32 (9), p.1029-1038</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-e893d8092e87cac4ade3fe5095592a075db119b819d8e608f27a8ac9ad53a9843</citedby><cites>FETCH-LOGICAL-c397t-e893d8092e87cac4ade3fe5095592a075db119b819d8e608f27a8ac9ad53a9843</cites><orcidid>0000-0003-4671-0211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10552-021-01455-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10552-021-01455-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34089471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dong Hoon</creatorcontrib><creatorcontrib>Keum, NaNa</creatorcontrib><creatorcontrib>Rezende, Leandro F. M.</creatorcontrib><creatorcontrib>Tabung, Fred K.</creatorcontrib><creatorcontrib>Hong, SungEun</creatorcontrib><creatorcontrib>Giovannucci, Edward L.</creatorcontrib><title>Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Purpose
Weight cycling is common in populations. However, it is unclear whether frequency and magnitude of weight cycling is associated with kidney cancer risk, independent of body mass index (BMI).
Methods
A prospective cohort study followed 85,562 participants from Health Professionals Follow-up Study and Nurses’ Health Study (1992–2014). At baseline, participants reported frequency and magnitude of intentional weight loss in the past 4 years. Cox proportional hazard model was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). We also conducted a meta-analysis of all available observational studies including our two cohorts.
Results
During 22 years of follow-up, we identified 441 kidney cancer cases. Compared with non-weight cyclers (no attempt of intentional weight loss), severe cyclers (≥ 3 times of intentional weight loss of ≥ 4.5 kg) were at increased kidney cancer risk after adjusting for BMI before weight cycling (pooled multivariable-adjusted HR, 1.78; 95% CI, 1.19, 2.66). Additional adjustment for attained BMI after weight cycling had minimal influence. There was a positive trend between weight cycling by frequency and magnitude and kidney cancer risk (
P
-trend = 0.01). Moreover, the observed positive association did not differ by subtypes of cyclers (e.g., adiposity status, weight-loss methods). In the meta-analysis, we found a strong positive association between weight cycling and kidney cancer risk (summary relative risk for weight cyclers vs. non-cyclers, 1.51; 95% CI, 1.16, 1.96; I
2
: 52.2%; 6 studies).
Conclusion
Frequent substantial weight cycling was associated with increased risk of kidney cancer, independent of BMI. Our study suggests that weight cycling may be an important risk factor for kidney cancer.</description><subject>Adipose tissue</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight loss</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Cycles</subject><subject>Epidemiology</subject><subject>Follow-Up Studies</subject><subject>Health risks</subject><subject>Hematology</subject><subject>Humans</subject><subject>Kidney cancer</subject><subject>Kidney Neoplasms - epidemiology</subject><subject>Kidney Neoplasms - etiology</subject><subject>Kidneys</subject><subject>Medical personnel</subject><subject>Meta-analysis</subject><subject>Obesity</subject><subject>Observational studies</subject><subject>Observational Studies as Topic</subject><subject>Oncology</subject><subject>ORIGINAL PAPER</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Statistical models</subject><subject>Weight Gain</subject><subject>Weight Loss</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kctKAzEUhoMotlZfQFAG3LgZzbVJwE0p3qDgRtchzZyp00umJjOUvr3RqRVcuDqLfP9_Dl8QOif4hmAsbyPBQtAcU5JjwoXI9QHqEyFZLikVh6iPtZC5oJz10EmMc4yxGFJ8jHqMY6W5JH10N4qxdpVtqtpnU2g2AD7bQDV7bzK3dcvKzzLriyxUcZHVZbaoCg_bzFnvIJyio9IuI5zt5gC9Pdy_jp_yycvj83g0yR3TsslBaVYorCko6azjtgBWgkjXCU0tlqKYEqKniuhCwRCrkkqrrNO2EMxqxdkAXXe961B_tBAbs6qig-XSeqjbaKhgcsi5piShV3_Qed0Gn65LlOBDKYiUiaId5UIdY4DSrEO1smFrCDZfbk3n1iS35tut0Sl0uatupyso9pEfmQlgHRDTk59B-N39b-1Fl5rHpg77Vq5k-klC2CdqbIxO</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Lee, Dong Hoon</creator><creator>Keum, NaNa</creator><creator>Rezende, Leandro F. M.</creator><creator>Tabung, Fred K.</creator><creator>Hong, SungEun</creator><creator>Giovannucci, Edward L.</creator><general>Springer Science + Business Media</general><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4671-0211</orcidid></search><sort><creationdate>20210901</creationdate><title>Association between weight cycling and risk of kidney cancer</title><author>Lee, Dong Hoon ; Keum, NaNa ; Rezende, Leandro F. M. ; Tabung, Fred K. ; Hong, SungEun ; Giovannucci, Edward L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-e893d8092e87cac4ade3fe5095592a075db119b819d8e608f27a8ac9ad53a9843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight loss</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Cycles</topic><topic>Epidemiology</topic><topic>Follow-Up Studies</topic><topic>Health risks</topic><topic>Hematology</topic><topic>Humans</topic><topic>Kidney cancer</topic><topic>Kidney Neoplasms - epidemiology</topic><topic>Kidney Neoplasms - etiology</topic><topic>Kidneys</topic><topic>Medical personnel</topic><topic>Meta-analysis</topic><topic>Obesity</topic><topic>Observational studies</topic><topic>Observational Studies as Topic</topic><topic>Oncology</topic><topic>ORIGINAL PAPER</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Statistical models</topic><topic>Weight Gain</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Dong Hoon</creatorcontrib><creatorcontrib>Keum, NaNa</creatorcontrib><creatorcontrib>Rezende, Leandro F. M.</creatorcontrib><creatorcontrib>Tabung, Fred K.</creatorcontrib><creatorcontrib>Hong, SungEun</creatorcontrib><creatorcontrib>Giovannucci, Edward L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dong Hoon</au><au>Keum, NaNa</au><au>Rezende, Leandro F. M.</au><au>Tabung, Fred K.</au><au>Hong, SungEun</au><au>Giovannucci, Edward L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies</atitle><jtitle>Cancer causes & control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>32</volume><issue>9</issue><spage>1029</spage><epage>1038</epage><pages>1029-1038</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><abstract>Purpose
Weight cycling is common in populations. However, it is unclear whether frequency and magnitude of weight cycling is associated with kidney cancer risk, independent of body mass index (BMI).
Methods
A prospective cohort study followed 85,562 participants from Health Professionals Follow-up Study and Nurses’ Health Study (1992–2014). At baseline, participants reported frequency and magnitude of intentional weight loss in the past 4 years. Cox proportional hazard model was used to estimate hazard ratios (HR) and 95% confidence intervals (CI). We also conducted a meta-analysis of all available observational studies including our two cohorts.
Results
During 22 years of follow-up, we identified 441 kidney cancer cases. Compared with non-weight cyclers (no attempt of intentional weight loss), severe cyclers (≥ 3 times of intentional weight loss of ≥ 4.5 kg) were at increased kidney cancer risk after adjusting for BMI before weight cycling (pooled multivariable-adjusted HR, 1.78; 95% CI, 1.19, 2.66). Additional adjustment for attained BMI after weight cycling had minimal influence. There was a positive trend between weight cycling by frequency and magnitude and kidney cancer risk (
P
-trend = 0.01). Moreover, the observed positive association did not differ by subtypes of cyclers (e.g., adiposity status, weight-loss methods). In the meta-analysis, we found a strong positive association between weight cycling and kidney cancer risk (summary relative risk for weight cyclers vs. non-cyclers, 1.51; 95% CI, 1.16, 1.96; I
2
: 52.2%; 6 studies).
Conclusion
Frequent substantial weight cycling was associated with increased risk of kidney cancer, independent of BMI. Our study suggests that weight cycling may be an important risk factor for kidney cancer.</abstract><cop>Cham</cop><pub>Springer Science + Business Media</pub><pmid>34089471</pmid><doi>10.1007/s10552-021-01455-9</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4671-0211</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0957-5243 |
| ispartof | Cancer causes & control, 2021-09, Vol.32 (9), p.1029-1038 |
| issn | 0957-5243 1573-7225 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2537644921 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adipose tissue Biomedical and Life Sciences Biomedicine Body mass Body Mass Index Body size Body weight loss Cancer Cancer Research Cohort analysis Confidence intervals Cycles Epidemiology Follow-Up Studies Health risks Hematology Humans Kidney cancer Kidney Neoplasms - epidemiology Kidney Neoplasms - etiology Kidneys Medical personnel Meta-analysis Obesity Observational studies Observational Studies as Topic Oncology ORIGINAL PAPER Prospective Studies Public Health Risk analysis Risk Factors Statistical models Weight Gain Weight Loss |
| title | Association between weight cycling and risk of kidney cancer: a prospective cohort study and meta-analysis of observational studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T12%3A48%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20weight%20cycling%20and%20risk%20of%20kidney%20cancer:%20a%20prospective%20cohort%20study%20and%20meta-analysis%20of%20observational%20studies&rft.jtitle=Cancer%20causes%20&%20control&rft.au=Lee,%20Dong%20Hoon&rft.date=2021-09-01&rft.volume=32&rft.issue=9&rft.spage=1029&rft.epage=1038&rft.pages=1029-1038&rft.issn=0957-5243&rft.eissn=1573-7225&rft_id=info:doi/10.1007/s10552-021-01455-9&rft_dat=%3Cjstor_proqu%3E48757311%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2554675177&rft_id=info:pmid/34089471&rft_jstor_id=48757311&rfr_iscdi=true |