Determination of eight endocrine disruptor pesticides in bovine milk at trace levels by dispersive liquid‐liquid microextraction followed by GC‐MS determination
Endocrine disrupting chemicals are chemicals that interfere with any aspect of the endocrine system. Several natural and synthetic chemicals, including pesticides, have been identified as endocrine disruptors, which potentially inhibit the reproductive activity of the hormonal system. The pervasive...
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| Veröffentlicht in: | Journal of separation science 2021-08, Vol.44 (15), p.2982-2995 |
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| creator | Sharma, Nisha Thakur, Pragati Chaskar, Manohar G. |
| description | Endocrine disrupting chemicals are chemicals that interfere with any aspect of the endocrine system. Several natural and synthetic chemicals, including pesticides, have been identified as endocrine disruptors, which potentially inhibit the reproductive activity of the hormonal system. The pervasive occurrence with trace level concentrations and extensive variety are the reported characteristics of these chemicals.
In this study, a dispersive liquid‐liquid microextraction method coupled with gas chromatography and mass spectrometry for the determination of eight potential endocrine disruptor pesticides (Lindane, Diazinon, Fenitrothion, Malathion, Aldrin, α‐Endosulfan, β‐Endosulfan, Methoxychlor) in bovine milk samples was developed. Several parameters that can influence the extraction efficiency were studied. Under optimized conditions, the calibration curves of all eight analytes presented coefficient of determination higher than 0.998 (range level of 2.0‐1000 ng/mL). The limits of detection and quantification ranged from 0.90 to 5.00 ng/mL and 2.50 to 15.0 ng/mL, respectively. |
| doi_str_mv | 10.1002/jssc.202100183 |
| format | Article |
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In this study, a dispersive liquid‐liquid microextraction method coupled with gas chromatography and mass spectrometry for the determination of eight potential endocrine disruptor pesticides (Lindane, Diazinon, Fenitrothion, Malathion, Aldrin, α‐Endosulfan, β‐Endosulfan, Methoxychlor) in bovine milk samples was developed. Several parameters that can influence the extraction efficiency were studied. Under optimized conditions, the calibration curves of all eight analytes presented coefficient of determination higher than 0.998 (range level of 2.0‐1000 ng/mL). The limits of detection and quantification ranged from 0.90 to 5.00 ng/mL and 2.50 to 15.0 ng/mL, respectively.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.202100183</identifier><identifier>PMID: 34085766</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Aldrin ; Animals ; Cattle ; Dispersion ; dispersive liquid‐liquid microextraction ; Endocrine disruptors ; Endocrine Disruptors - analysis ; endocrine‐disrupting pesticides ; Gas chromatography ; Gas Chromatography-Mass Spectrometry - methods ; Limit of Detection ; Liquid Phase Microextraction - methods ; Mass spectrometry ; milk ; Milk - chemistry ; Pesticides ; Pesticides - analysis ; preconcentration ; sample preparation ; Solvents - chemistry</subject><ispartof>Journal of separation science, 2021-08, Vol.44 (15), p.2982-2995</ispartof><rights>2021 Wiley‐VCH GmbH</rights><rights>2021 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3682-7bd384860a7adc0a683de04b730d6dc07c860a6db0945808e45e0d3675085ffc3</citedby><cites>FETCH-LOGICAL-c3682-7bd384860a7adc0a683de04b730d6dc07c860a6db0945808e45e0d3675085ffc3</cites><orcidid>0000-0003-3243-7832</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.202100183$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.202100183$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34085766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, Nisha</creatorcontrib><creatorcontrib>Thakur, Pragati</creatorcontrib><creatorcontrib>Chaskar, Manohar G.</creatorcontrib><title>Determination of eight endocrine disruptor pesticides in bovine milk at trace levels by dispersive liquid‐liquid microextraction followed by GC‐MS determination</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>Endocrine disrupting chemicals are chemicals that interfere with any aspect of the endocrine system. Several natural and synthetic chemicals, including pesticides, have been identified as endocrine disruptors, which potentially inhibit the reproductive activity of the hormonal system. The pervasive occurrence with trace level concentrations and extensive variety are the reported characteristics of these chemicals.
In this study, a dispersive liquid‐liquid microextraction method coupled with gas chromatography and mass spectrometry for the determination of eight potential endocrine disruptor pesticides (Lindane, Diazinon, Fenitrothion, Malathion, Aldrin, α‐Endosulfan, β‐Endosulfan, Methoxychlor) in bovine milk samples was developed. Several parameters that can influence the extraction efficiency were studied. Under optimized conditions, the calibration curves of all eight analytes presented coefficient of determination higher than 0.998 (range level of 2.0‐1000 ng/mL). The limits of detection and quantification ranged from 0.90 to 5.00 ng/mL and 2.50 to 15.0 ng/mL, respectively.</description><subject>Aldrin</subject><subject>Animals</subject><subject>Cattle</subject><subject>Dispersion</subject><subject>dispersive liquid‐liquid microextraction</subject><subject>Endocrine disruptors</subject><subject>Endocrine Disruptors - analysis</subject><subject>endocrine‐disrupting pesticides</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry - methods</subject><subject>Limit of Detection</subject><subject>Liquid Phase Microextraction - methods</subject><subject>Mass spectrometry</subject><subject>milk</subject><subject>Milk - chemistry</subject><subject>Pesticides</subject><subject>Pesticides - analysis</subject><subject>preconcentration</subject><subject>sample preparation</subject><subject>Solvents - chemistry</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb-O1DAQxi0E4v5AS4ks0dDsMokd21uiPThAhygW6sixJ-DFiXN2ssd29wg8BE_Gk-CwxwrRUHk88_vGM_4IeVLAsgAoX2xTMssSynwpFLtHTgtRVIsVK_j9YwzihJyltM2IVCt4SE4YB1VJIU7JjwscMXau16MLPQ0tRff5y0ixt8FE1yO1LsVpGEOkA6bRGWcxUdfTJuzmcuf8V6pHOkZtkHrcoU-02c-yAWNyu5x015OzP2-_H4IsMTHgt1nx-9E2eB9u0M6yy3Xm3m-o_XusR-RBq33Cx3fnOfn0-tXH9ZvF1YfLt-uXVwvDhCoXsrFMcSVAS20NaKGYReCNZGBFTkgz14RtYMUrBQp5hWCZkFX-jbY17Jw8P_QdYrie8rZ155JB73WPYUp1WTEpOBe8zOizf9BtmGKfp8uUgGwHVFWmlgcqL5xSxLYeout03NcF1LN_9exfffQvC57etZ2aDu0R_2NYBvgBuHEe9_9pV7_bbNaSFSX7BYg2q5Q</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Sharma, Nisha</creator><creator>Thakur, Pragati</creator><creator>Chaskar, Manohar G.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3243-7832</orcidid></search><sort><creationdate>202108</creationdate><title>Determination of eight endocrine disruptor pesticides in bovine milk at trace levels by dispersive liquid‐liquid microextraction followed by GC‐MS determination</title><author>Sharma, Nisha ; Thakur, Pragati ; Chaskar, Manohar G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3682-7bd384860a7adc0a683de04b730d6dc07c860a6db0945808e45e0d3675085ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aldrin</topic><topic>Animals</topic><topic>Cattle</topic><topic>Dispersion</topic><topic>dispersive liquid‐liquid microextraction</topic><topic>Endocrine disruptors</topic><topic>Endocrine Disruptors - analysis</topic><topic>endocrine‐disrupting pesticides</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry - methods</topic><topic>Limit of Detection</topic><topic>Liquid Phase Microextraction - methods</topic><topic>Mass spectrometry</topic><topic>milk</topic><topic>Milk - chemistry</topic><topic>Pesticides</topic><topic>Pesticides - analysis</topic><topic>preconcentration</topic><topic>sample preparation</topic><topic>Solvents - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, Nisha</creatorcontrib><creatorcontrib>Thakur, Pragati</creatorcontrib><creatorcontrib>Chaskar, Manohar G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, Nisha</au><au>Thakur, Pragati</au><au>Chaskar, Manohar G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of eight endocrine disruptor pesticides in bovine milk at trace levels by dispersive liquid‐liquid microextraction followed by GC‐MS determination</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2021-08</date><risdate>2021</risdate><volume>44</volume><issue>15</issue><spage>2982</spage><epage>2995</epage><pages>2982-2995</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>Endocrine disrupting chemicals are chemicals that interfere with any aspect of the endocrine system. Several natural and synthetic chemicals, including pesticides, have been identified as endocrine disruptors, which potentially inhibit the reproductive activity of the hormonal system. The pervasive occurrence with trace level concentrations and extensive variety are the reported characteristics of these chemicals.
In this study, a dispersive liquid‐liquid microextraction method coupled with gas chromatography and mass spectrometry for the determination of eight potential endocrine disruptor pesticides (Lindane, Diazinon, Fenitrothion, Malathion, Aldrin, α‐Endosulfan, β‐Endosulfan, Methoxychlor) in bovine milk samples was developed. Several parameters that can influence the extraction efficiency were studied. Under optimized conditions, the calibration curves of all eight analytes presented coefficient of determination higher than 0.998 (range level of 2.0‐1000 ng/mL). The limits of detection and quantification ranged from 0.90 to 5.00 ng/mL and 2.50 to 15.0 ng/mL, respectively.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34085766</pmid><doi>10.1002/jssc.202100183</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-3243-7832</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aldrin Animals Cattle Dispersion dispersive liquid‐liquid microextraction Endocrine disruptors Endocrine Disruptors - analysis endocrine‐disrupting pesticides Gas chromatography Gas Chromatography-Mass Spectrometry - methods Limit of Detection Liquid Phase Microextraction - methods Mass spectrometry milk Milk - chemistry Pesticides Pesticides - analysis preconcentration sample preparation Solvents - chemistry |
| title | Determination of eight endocrine disruptor pesticides in bovine milk at trace levels by dispersive liquid‐liquid microextraction followed by GC‐MS determination |
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