Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency
We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a con...
Gespeichert in:
Veröffentlicht in: | Ultrasound in medicine & biology 2021-08, Vol.47 (8), p.2377-2387 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 2387 |
---|---|
container_issue | 8 |
container_start_page | 2377 |
container_title | Ultrasound in medicine & biology |
container_volume | 47 |
creator | Tang, Huajun Liu, Yao Fan, Yijin Li, Chengzhi |
description | We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a control group); 22 normal rats without premature ovarian insufficiency were also included as a third group. The ultrasound group was treated with LIPUS, while the other two groups received the same treatment but without any power output. We monitored the estrous cycles of all rats. Seven days after treatment, 21 rats were selected to mate with male rats. We then recorded the pregnancy rate along with the number and weight of newborn rats per nest. We collected samples of blood, uterus and ovaries from the remaining 45 rats before they were sacrificed. Compared with the normal group, the control group exhibited disordered estrous cycles, more atretic follicles (p < 0.01), higher levels of serum follicle-stimulating hormone (p < 0.01), fewer other follicles (p < 0.01) and lower serum levels of E2 and anti-Müllerian hormone (p < 0.01). Compared with the control group, the ultrasound group had normal estrous cycles with fewer atretic follicles (p < 0.01), lower levels of serum follicle-stimulating hormone (p < 0.01), more other follicles (p < 0.01) and higher levels of serum E2 (p < 0.01). No significant difference in the levels of serum anti-Müllerian hormone was noted between the control group and the ultrasound group. No significant differences were observed between the three groups with respect to pregnancy rate or the number and weight of newborns per nest (p > 0.05). In conclusion, our data indicate that LIPUS could improve some ovarian functions of rats with premature ovarian insufficiency. |
doi_str_mv | 10.1016/j.ultrasmedbio.2021.04.022 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2537644127</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301562921002015</els_id><sourcerecordid>2537644127</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-befff2b7e81a360c6a7d956d7f02ba3ab67fbf20a78db60d495f6502c458f0193</originalsourceid><addsrcrecordid>eNqNkD1PwzAURS0EEqXwHywmloRnJ7EbNlS-KlVqB5Bgshz7Wbhq42InRf33BMrAyPSWe-7TPYRcMsgZMHG9yvt1F3XaoG18yDlwlkOZA-dHZMQmss54zV6PyQgKYFkleH1KzlJaAYAUhRyRt-d3jHqLfecNvXcOTZdocHQePrNZ22GbfLeny36d0NKXn1-hby0NLV1G3Oiuj0gXOx29bumsTb1z3nhszf6cnDg9YBe_d0xeHu6fp0_ZfPE4m97OM1NC3WUNOud4I3HCdCHACC1tXQkrHfBGF7oR0jWOg5YT2wiwZV05UQE3ZTVxwOpiTK4OvdsYPnpMndr4ZHC91i2GPileFVKUJeNyiN4coiaGlCI6tY1-o-NeMVDfPtVK_fWpvn0qKNXgc4DvDjAOY3Yeo0o_Q9H6OFhTNvj_1HwBx5SHxQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2537644127</pqid></control><display><type>article</type><title>Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Tang, Huajun ; Liu, Yao ; Fan, Yijin ; Li, Chengzhi</creator><creatorcontrib>Tang, Huajun ; Liu, Yao ; Fan, Yijin ; Li, Chengzhi</creatorcontrib><description><![CDATA[We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a control group); 22 normal rats without premature ovarian insufficiency were also included as a third group. The ultrasound group was treated with LIPUS, while the other two groups received the same treatment but without any power output. We monitored the estrous cycles of all rats. Seven days after treatment, 21 rats were selected to mate with male rats. We then recorded the pregnancy rate along with the number and weight of newborn rats per nest. We collected samples of blood, uterus and ovaries from the remaining 45 rats before they were sacrificed. Compared with the normal group, the control group exhibited disordered estrous cycles, more atretic follicles (p < 0.01), higher levels of serum follicle-stimulating hormone (p < 0.01), fewer other follicles (p < 0.01) and lower serum levels of E2 and anti-Müllerian hormone (p < 0.01). Compared with the control group, the ultrasound group had normal estrous cycles with fewer atretic follicles (p < 0.01), lower levels of serum follicle-stimulating hormone (p < 0.01), more other follicles (p < 0.01) and higher levels of serum E2 (p < 0.01). No significant difference in the levels of serum anti-Müllerian hormone was noted between the control group and the ultrasound group. No significant differences were observed between the three groups with respect to pregnancy rate or the number and weight of newborns per nest (p > 0.05). In conclusion, our data indicate that LIPUS could improve some ovarian functions of rats with premature ovarian insufficiency.]]></description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2021.04.022</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Cyclophosphamide ; Low-intensity pulsed ultrasound ; Premature ovarian failure ; Premature ovarian insufficiency</subject><ispartof>Ultrasound in medicine & biology, 2021-08, Vol.47 (8), p.2377-2387</ispartof><rights>2021 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-befff2b7e81a360c6a7d956d7f02ba3ab67fbf20a78db60d495f6502c458f0193</citedby><cites>FETCH-LOGICAL-c409t-befff2b7e81a360c6a7d956d7f02ba3ab67fbf20a78db60d495f6502c458f0193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2021.04.022$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Tang, Huajun</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Fan, Yijin</creatorcontrib><creatorcontrib>Li, Chengzhi</creatorcontrib><title>Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency</title><title>Ultrasound in medicine & biology</title><description><![CDATA[We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a control group); 22 normal rats without premature ovarian insufficiency were also included as a third group. The ultrasound group was treated with LIPUS, while the other two groups received the same treatment but without any power output. We monitored the estrous cycles of all rats. Seven days after treatment, 21 rats were selected to mate with male rats. We then recorded the pregnancy rate along with the number and weight of newborn rats per nest. We collected samples of blood, uterus and ovaries from the remaining 45 rats before they were sacrificed. Compared with the normal group, the control group exhibited disordered estrous cycles, more atretic follicles (p < 0.01), higher levels of serum follicle-stimulating hormone (p < 0.01), fewer other follicles (p < 0.01) and lower serum levels of E2 and anti-Müllerian hormone (p < 0.01). Compared with the control group, the ultrasound group had normal estrous cycles with fewer atretic follicles (p < 0.01), lower levels of serum follicle-stimulating hormone (p < 0.01), more other follicles (p < 0.01) and higher levels of serum E2 (p < 0.01). No significant difference in the levels of serum anti-Müllerian hormone was noted between the control group and the ultrasound group. No significant differences were observed between the three groups with respect to pregnancy rate or the number and weight of newborns per nest (p > 0.05). In conclusion, our data indicate that LIPUS could improve some ovarian functions of rats with premature ovarian insufficiency.]]></description><subject>Cyclophosphamide</subject><subject>Low-intensity pulsed ultrasound</subject><subject>Premature ovarian failure</subject><subject>Premature ovarian insufficiency</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqNkD1PwzAURS0EEqXwHywmloRnJ7EbNlS-KlVqB5Bgshz7Wbhq42InRf33BMrAyPSWe-7TPYRcMsgZMHG9yvt1F3XaoG18yDlwlkOZA-dHZMQmss54zV6PyQgKYFkleH1KzlJaAYAUhRyRt-d3jHqLfecNvXcOTZdocHQePrNZ22GbfLeny36d0NKXn1-hby0NLV1G3Oiuj0gXOx29bumsTb1z3nhszf6cnDg9YBe_d0xeHu6fp0_ZfPE4m97OM1NC3WUNOud4I3HCdCHACC1tXQkrHfBGF7oR0jWOg5YT2wiwZV05UQE3ZTVxwOpiTK4OvdsYPnpMndr4ZHC91i2GPileFVKUJeNyiN4coiaGlCI6tY1-o-NeMVDfPtVK_fWpvn0qKNXgc4DvDjAOY3Yeo0o_Q9H6OFhTNvj_1HwBx5SHxQ</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Tang, Huajun</creator><creator>Liu, Yao</creator><creator>Fan, Yijin</creator><creator>Li, Chengzhi</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202108</creationdate><title>Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency</title><author>Tang, Huajun ; Liu, Yao ; Fan, Yijin ; Li, Chengzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-befff2b7e81a360c6a7d956d7f02ba3ab67fbf20a78db60d495f6502c458f0193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cyclophosphamide</topic><topic>Low-intensity pulsed ultrasound</topic><topic>Premature ovarian failure</topic><topic>Premature ovarian insufficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Huajun</creatorcontrib><creatorcontrib>Liu, Yao</creatorcontrib><creatorcontrib>Fan, Yijin</creatorcontrib><creatorcontrib>Li, Chengzhi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Huajun</au><au>Liu, Yao</au><au>Fan, Yijin</au><au>Li, Chengzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency</atitle><jtitle>Ultrasound in medicine & biology</jtitle><date>2021-08</date><risdate>2021</risdate><volume>47</volume><issue>8</issue><spage>2377</spage><epage>2387</epage><pages>2377-2387</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract><![CDATA[We explored the therapeutic effects of low-intensity pulsed ultrasound (LIPUS) on a rat model of ovarian damage induced by cyclophosphamide. A total of 44 female rats with premature ovarian insufficiency induced by cyclophosphamide were randomly divided into two groups (an ultrasound group and a control group); 22 normal rats without premature ovarian insufficiency were also included as a third group. The ultrasound group was treated with LIPUS, while the other two groups received the same treatment but without any power output. We monitored the estrous cycles of all rats. Seven days after treatment, 21 rats were selected to mate with male rats. We then recorded the pregnancy rate along with the number and weight of newborn rats per nest. We collected samples of blood, uterus and ovaries from the remaining 45 rats before they were sacrificed. Compared with the normal group, the control group exhibited disordered estrous cycles, more atretic follicles (p < 0.01), higher levels of serum follicle-stimulating hormone (p < 0.01), fewer other follicles (p < 0.01) and lower serum levels of E2 and anti-Müllerian hormone (p < 0.01). Compared with the control group, the ultrasound group had normal estrous cycles with fewer atretic follicles (p < 0.01), lower levels of serum follicle-stimulating hormone (p < 0.01), more other follicles (p < 0.01) and higher levels of serum E2 (p < 0.01). No significant difference in the levels of serum anti-Müllerian hormone was noted between the control group and the ultrasound group. No significant differences were observed between the three groups with respect to pregnancy rate or the number and weight of newborns per nest (p > 0.05). In conclusion, our data indicate that LIPUS could improve some ovarian functions of rats with premature ovarian insufficiency.]]></abstract><pub>Elsevier Inc</pub><doi>10.1016/j.ultrasmedbio.2021.04.022</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0301-5629 |
ispartof | Ultrasound in medicine & biology, 2021-08, Vol.47 (8), p.2377-2387 |
issn | 0301-5629 1879-291X |
language | eng |
recordid | cdi_proquest_miscellaneous_2537644127 |
source | Elsevier ScienceDirect Journals Complete |
subjects | Cyclophosphamide Low-intensity pulsed ultrasound Premature ovarian failure Premature ovarian insufficiency |
title | Therapeutic Effects of Low-Intensity Pulsed Ultrasound on Premature Ovarian Insufficiency |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A39%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20Effects%20of%20Low-Intensity%20Pulsed%20Ultrasound%20on%20Premature%20Ovarian%20Insufficiency&rft.jtitle=Ultrasound%20in%20medicine%20&%20biology&rft.au=Tang,%20Huajun&rft.date=2021-08&rft.volume=47&rft.issue=8&rft.spage=2377&rft.epage=2387&rft.pages=2377-2387&rft.issn=0301-5629&rft.eissn=1879-291X&rft_id=info:doi/10.1016/j.ultrasmedbio.2021.04.022&rft_dat=%3Cproquest_cross%3E2537644127%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2537644127&rft_id=info:pmid/&rft_els_id=S0301562921002015&rfr_iscdi=true |