The development of zebrafish pancreas affected by deficiency of Hedgehog signaling
The pancreas development depends on complex regulation of several signaling pathways, including the Hedgehog (Hh) signaling via a receptor complex component, Smoothened, which deficiency blocks the Hh signaling. Such a defect in birds and mammals results in an annular pancreas. We showed that in dev...
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| Veröffentlicht in: | Gene Expression Patterns 2021-09, Vol.41, p.119185-119185, Article 119185 |
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| container_title | Gene Expression Patterns |
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| creator | Korzh, Svitlana Winata, Cecilia L. Gong, Zhiyuan Korzh, Vladimir |
| description | The pancreas development depends on complex regulation of several signaling pathways, including the Hedgehog (Hh) signaling via a receptor complex component, Smoothened, which deficiency blocks the Hh signaling. Such a defect in birds and mammals results in an annular pancreas. We showed that in developing zebrafish, the mutation of Smoothened or inhibition of Hh signaling by its antagonist cyclopamine caused developmental defects of internal organs, liver, pancreas, and gut. In particular, the pancreatic primordium was duplicated. The two exocrine pancreatic primordia surround the gut. This phenomenon correlates with a significant reduction of the gut's diameter, causing the annular pancreas phenotype. |
| doi_str_mv | 10.1016/j.gep.2021.119185 |
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| ispartof | Gene Expression Patterns, 2021-09, Vol.41, p.119185-119185, Article 119185 |
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| subjects | Animals Annular pancreas Elastase Green fluorescent protein (GFP) Hedgehog Proteins - genetics Pancreas Signal Transduction Smoothened Receptor - genetics Smoothened Receptor - metabolism Transgenic Zebrafish Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
| title | The development of zebrafish pancreas affected by deficiency of Hedgehog signaling |
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