Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility

For the first time, the fatty acid metabolite, long-chain acylcarnitine 18:1, is shown to acutely increase the arrhythmia susceptibility and contractility of human atrial myocardium. In vitro, this was linked to an influx of Ca 2+ and an enhanced propensity for spontaneous RyR2-mediated Ca 2+ releas...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2021-07, Vol.321 (1), p.H162-H174
Hauptverfasser:	Aitken-Buck, Hamish M., Krause, Julia, van Hout, Isabelle, Davis, Philip J., Bunton, Richard W., Parry, Dominic J., Williams, Michael J. A., Coffey, Sean, Zeller, Tanja, Jones, Peter P., Lamberts, Regis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmia Calcium influx Calcium ions Cardiac arrhythmia Cardiovascular diseases Electrophysiology Heart Metabolites Muscle contraction Muscles Muscular function Myocardium Ryanodine receptors
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