Development of LC-HRMS methods for evaluation of metabolic conversion of 5-fluorocytosine at GDEPT procedure

[Display omitted] •Development of two different LC-HRMS methods for evaluation of GDEPT efficiency.•Identification and quantification of 5FC, 5FU and its metabolites in cells after GDEPT.•Gene-directed enzyme prodrug therapy on tumour and mesenchymal stem cells.•Metabolic conversion of 5FC was confi...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2021-09, Vol.203, p.114168-114168, Article 114168
Hauptverfasser:	Skvara, Pavel, Durinikova, Erika, Grabicová, Kateřina, Mordacikova, Erika, Matuskova, Miroslava, Vojs Stanova, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	5-fluorouracil Cancer therapy Chemotherapeutics High resolution mass spectrometry Metabolites
Online-Zugang:	Volltext
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