Research progress on live attenuated vaccine against African swine fever virus
African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanis...
Gespeichert in:
| Veröffentlicht in: | Microbial pathogenesis 2021-09, Vol.158, p.105024-105024, Article 105024 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 105024 |
|---|---|
| container_issue | |
| container_start_page | 105024 |
| container_title | Microbial pathogenesis |
| container_volume | 158 |
| creator | Liu, Le Wang, Xiangwei Mao, Ruoqing Zhou, Yahua Yin, Juanbin Sun, Yuefeng Yin, Xiangping |
| description | African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.
•Natural-attenuated strains and subculture-attenuated strains of ASFV provides a poor immune response and side effects.•Recombinant-attenuated vaccine of ASFV provides a greater protection after ASFV challenge, however the application of these vaccine need to be further investigated.•Sustainable cell lines that are susceptible to the infection of ASFV are very important and in great demand. |
| doi_str_mv | 10.1016/j.micpath.2021.105024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2537640165</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0882401021002965</els_id><sourcerecordid>2537640165</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-81745be54dacd77b0b1ed7288b150810da64f595eb2658730c4d3a8e31678ce33</originalsourceid><addsrcrecordid>eNqFkF9LwzAUxYMoOKcfQeijL503SdOmTzKG_2AoiD6HNLndMrp2JmnFb29H9-7ThcM5h3t-hNxSWFCg-f1usXfmoON2wYDRURPAsjMyo1DmKWUgz8kMpGRpBhQuyVUIOwAoM17OyNsHBtTebJOD7zYeQ0i6NmncgImOEdteR7TJoI1x7ShttGtDTJa1d0a3Sfg5qjUO6JPB-T5ck4taNwFvTndOvp4eP1cv6fr9-XW1XKeGyzKmkhaZqFBkVhtbFBVUFG3BpKyoAEnB6jyrRSmwYrmQBQeTWa4lcpoX0iDnc3I39Y5ff_cYotq7YLBpdItdHxQTvMjHubkYrWKyGt-F4LFWB-_22v8qCurIT-3UiZ868lMTvzH3MOVw3DE49CoYh61B6zyaqGzn_mn4A0qQe7E</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2537640165</pqid></control><display><type>article</type><title>Research progress on live attenuated vaccine against African swine fever virus</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Liu, Le ; Wang, Xiangwei ; Mao, Ruoqing ; Zhou, Yahua ; Yin, Juanbin ; Sun, Yuefeng ; Yin, Xiangping</creator><creatorcontrib>Liu, Le ; Wang, Xiangwei ; Mao, Ruoqing ; Zhou, Yahua ; Yin, Juanbin ; Sun, Yuefeng ; Yin, Xiangping</creatorcontrib><description>African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.
•Natural-attenuated strains and subculture-attenuated strains of ASFV provides a poor immune response and side effects.•Recombinant-attenuated vaccine of ASFV provides a greater protection after ASFV challenge, however the application of these vaccine need to be further investigated.•Sustainable cell lines that are susceptible to the infection of ASFV are very important and in great demand.</description><identifier>ISSN: 0882-4010</identifier><identifier>EISSN: 1096-1208</identifier><identifier>DOI: 10.1016/j.micpath.2021.105024</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>African swine fever virus ; Live-attenuated vaccines ; Protective immunity ; Safety</subject><ispartof>Microbial pathogenesis, 2021-09, Vol.158, p.105024-105024, Article 105024</ispartof><rights>2021 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-81745be54dacd77b0b1ed7288b150810da64f595eb2658730c4d3a8e31678ce33</citedby><cites>FETCH-LOGICAL-c389t-81745be54dacd77b0b1ed7288b150810da64f595eb2658730c4d3a8e31678ce33</cites><orcidid>0000-0002-1344-1740</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.micpath.2021.105024$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Liu, Le</creatorcontrib><creatorcontrib>Wang, Xiangwei</creatorcontrib><creatorcontrib>Mao, Ruoqing</creatorcontrib><creatorcontrib>Zhou, Yahua</creatorcontrib><creatorcontrib>Yin, Juanbin</creatorcontrib><creatorcontrib>Sun, Yuefeng</creatorcontrib><creatorcontrib>Yin, Xiangping</creatorcontrib><title>Research progress on live attenuated vaccine against African swine fever virus</title><title>Microbial pathogenesis</title><description>African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.
•Natural-attenuated strains and subculture-attenuated strains of ASFV provides a poor immune response and side effects.•Recombinant-attenuated vaccine of ASFV provides a greater protection after ASFV challenge, however the application of these vaccine need to be further investigated.•Sustainable cell lines that are susceptible to the infection of ASFV are very important and in great demand.</description><subject>African swine fever virus</subject><subject>Live-attenuated vaccines</subject><subject>Protective immunity</subject><subject>Safety</subject><issn>0882-4010</issn><issn>1096-1208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkF9LwzAUxYMoOKcfQeijL503SdOmTzKG_2AoiD6HNLndMrp2JmnFb29H9-7ThcM5h3t-hNxSWFCg-f1usXfmoON2wYDRURPAsjMyo1DmKWUgz8kMpGRpBhQuyVUIOwAoM17OyNsHBtTebJOD7zYeQ0i6NmncgImOEdteR7TJoI1x7ShttGtDTJa1d0a3Sfg5qjUO6JPB-T5ck4taNwFvTndOvp4eP1cv6fr9-XW1XKeGyzKmkhaZqFBkVhtbFBVUFG3BpKyoAEnB6jyrRSmwYrmQBQeTWa4lcpoX0iDnc3I39Y5ff_cYotq7YLBpdItdHxQTvMjHubkYrWKyGt-F4LFWB-_22v8qCurIT-3UiZ868lMTvzH3MOVw3DE49CoYh61B6zyaqGzn_mn4A0qQe7E</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Liu, Le</creator><creator>Wang, Xiangwei</creator><creator>Mao, Ruoqing</creator><creator>Zhou, Yahua</creator><creator>Yin, Juanbin</creator><creator>Sun, Yuefeng</creator><creator>Yin, Xiangping</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1344-1740</orcidid></search><sort><creationdate>202109</creationdate><title>Research progress on live attenuated vaccine against African swine fever virus</title><author>Liu, Le ; Wang, Xiangwei ; Mao, Ruoqing ; Zhou, Yahua ; Yin, Juanbin ; Sun, Yuefeng ; Yin, Xiangping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-81745be54dacd77b0b1ed7288b150810da64f595eb2658730c4d3a8e31678ce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>African swine fever virus</topic><topic>Live-attenuated vaccines</topic><topic>Protective immunity</topic><topic>Safety</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Le</creatorcontrib><creatorcontrib>Wang, Xiangwei</creatorcontrib><creatorcontrib>Mao, Ruoqing</creatorcontrib><creatorcontrib>Zhou, Yahua</creatorcontrib><creatorcontrib>Yin, Juanbin</creatorcontrib><creatorcontrib>Sun, Yuefeng</creatorcontrib><creatorcontrib>Yin, Xiangping</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbial pathogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Le</au><au>Wang, Xiangwei</au><au>Mao, Ruoqing</au><au>Zhou, Yahua</au><au>Yin, Juanbin</au><au>Sun, Yuefeng</au><au>Yin, Xiangping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research progress on live attenuated vaccine against African swine fever virus</atitle><jtitle>Microbial pathogenesis</jtitle><date>2021-09</date><risdate>2021</risdate><volume>158</volume><spage>105024</spage><epage>105024</epage><pages>105024-105024</pages><artnum>105024</artnum><issn>0882-4010</issn><eissn>1096-1208</eissn><abstract>African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.
•Natural-attenuated strains and subculture-attenuated strains of ASFV provides a poor immune response and side effects.•Recombinant-attenuated vaccine of ASFV provides a greater protection after ASFV challenge, however the application of these vaccine need to be further investigated.•Sustainable cell lines that are susceptible to the infection of ASFV are very important and in great demand.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.micpath.2021.105024</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1344-1740</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0882-4010 |
| ispartof | Microbial pathogenesis, 2021-09, Vol.158, p.105024-105024, Article 105024 |
| issn | 0882-4010 1096-1208 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2537640165 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | African swine fever virus Live-attenuated vaccines Protective immunity Safety |
| title | Research progress on live attenuated vaccine against African swine fever virus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T04%3A50%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Research%20progress%20on%20live%20attenuated%20vaccine%20against%20African%20swine%20fever%20virus&rft.jtitle=Microbial%20pathogenesis&rft.au=Liu,%20Le&rft.date=2021-09&rft.volume=158&rft.spage=105024&rft.epage=105024&rft.pages=105024-105024&rft.artnum=105024&rft.issn=0882-4010&rft.eissn=1096-1208&rft_id=info:doi/10.1016/j.micpath.2021.105024&rft_dat=%3Cproquest_cross%3E2537640165%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2537640165&rft_id=info:pmid/&rft_els_id=S0882401021002965&rfr_iscdi=true |