Transitional cell carcinoma matrix stiffness regulates the osteopontin and YAP expression in recurrent patients

Cells translate the mechanosensing of extracellular matrix component dysregulation and stiffness into the signal transduction including Osteopontin (OPN) through the Hippo pathway. But how extracellular matrix (ECM) component dysregulation and stiffness are ultimately linked to transitional cell car...

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Veröffentlicht in:	Molecular biology reports 2021-05, Vol.48 (5), p.4253-4262
Hauptverfasser:	Ghasemi, Hadi, Mousavibahar, Seyed Habibollah, Hashemnia, Mohammad, Karimi, Jamshid, Khodadadi, Iraj, Tavilani, Heidar
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animal Anatomy Animal Biochemistry Atomic force microscopy Biomedical and Life Sciences Carcinoma, Transitional Cell - blood Carcinoma, Transitional Cell - genetics Case-Control Studies Elastin - metabolism Extracellular matrix Extracellular Matrix - metabolism Female Fibers Gene Expression Gene Expression Regulation, Neoplastic Glycoproteins Hedgehog protein Hedgehog Proteins - genetics Hippo Signaling Pathway - genetics Histology Humans Life Sciences Male Morphology Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - genetics Original Article Osteopontin Osteopontin - blood Osteopontin - genetics Patients Proteoglycans - metabolism Serum levels Signal transduction Transitional cell carcinoma Up-Regulation - genetics Urinary Bladder Neoplasms - blood Urinary Bladder Neoplasms - genetics Western blotting YAP-Signaling Proteins - genetics Yes-associated protein
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