Novel inhibitor of OCT1 enhances the sensitivity of human esophageal squamous cell carcinoma cells to antitumor agents

Esophageal squamous cell carcinoma (ESCC) is one of the most fatal malignancies of the digestive system, and shows an especially high incidence in some regions of China. Octamer transcription factors are a family of transcription factors whose DNA-binding domain is a POU domain. OCT transcription fa...

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Veröffentlicht in:	European journal of pharmacology 2021-09, Vol.907, p.174222, Article 174222
Hauptverfasser:	Zou, Xiao-zheng, Zhou, Xiu-hua, Feng, Ying-qi, Hao, Jun-feng, Liang, Bing, Jia, Meng-wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Line, Tumor Chemotherapies Esophageal Neoplasms - drug therapy Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - drug therapy Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - pathology Gene Expression Regulation, Neoplastic - drug effects Humans Molecular Docking Simulation OCT transcription factors Octamer Transcription Factor-1 - genetics Octamer Transcription Factor-1 - metabolism Small-molecule inhibitors
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