Diagnostic challenges of focal nodular hyperplasia: interobserver variability, accuracy, and the utility of glutamine synthetase immunohistochemistry

Aims The diagnosis of focal nodular hyperplasia (FNH) and the interpretation of glutamine synthetase (GS) staining can be challenging on biopsies. We aimed to evaluate the reproducibility of needle biopsy diagnosis of FNH, the effect of GS immunohistochemistry on FNH diagnosis, and which histologica...

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Veröffentlicht in:	Histopathology 2021-11, Vol.79 (5), p.791-800
Hauptverfasser:	Rowan, Daniel J, Allende, Daniela S, Bellizzi, Andrew M, Gill, Ryan M, Liu, Xiuli, McKenzie, Catriona A, Moreira, Roger K, Mounajjed, Taofic, Said, Samar, Westerhoff, Maria, Jenkins, Sarah M, Batts, Kenneth P, Burgart, Lawrence J, Lamps, Laura W, Graham, Rondell P
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adenoma, Liver Cell - diagnosis Adenoma, Liver Cell - pathology Biomarkers, Tumor - analysis Biopsy Biopsy, Needle Data Accuracy Diagnosis Diagnosis, Differential Female focal nodular hyperplasia Focal Nodular Hyperplasia - diagnosis Focal Nodular Hyperplasia - pathology Glutamate-ammonia ligase Glutamate-Ammonia Ligase - analysis Glutamine glutamine synthetase Hepatocellular carcinoma Humans Hyperplasia Immunohistochemistry interobserver variability liver Liver - pathology Liver Neoplasms - diagnosis Liver Neoplasms - pathology Male needle biopsy Steatosis virtual biopsy
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